Thiamine pyrophosphate
Based on 1 publication(s) in Google Scholar
Thiamine pyrophosphate is the coenzyme form of Vitamin B1, and is a required intermediate in the pyruvate dehydrogenase complex and the ketoglutarate dehydrogenase complex. Thiamine pyrophosphate is necessary for oxidative phosphorylation and the pentose phosphate pathway by acting as a cofactor for α-ketoacid dehydrogenases.
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- Pureza : 99.93%
- No. CAS: 154-87-0
- Fòrmula: C12H19ClN4O7P2S
- Peso molecular:460.77
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Almacenamiento:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Publications Citing Use of MedChemExpress (MCE) Thiamine pyrophosphate
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Cell Imaging/Staining
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Histological Imaging/Staining
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In Vivo Efficacy Study
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Actividad biológica
Descripciòn
IC50 & Target
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Human Endogenous Metabolite |
In Vivo
Thiamine pyrophosphate (20 mg/kg, i.p., once a day for 14 days) prevents Cisplatin (HY-17394) induced cardiotoxicity, and associated oxidative stress and heart injury in rats[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Ensayo clínico
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | 2011-05 | PHASE1 |
Chemical Information
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No. CAS 154-87-0
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Appearance Solid
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Peso molecular 460.77
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Fòrmula C12H19ClN4O7P2S
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Color White to off-white
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SMILES
OP(OP(OCCC1=C(C)[N+](CC2=CN=C(C)N=C2N)=CS1)(O)=O)(O)=O.[Cl-]
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Synonyms
Cocarboxylase
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Structure Classification
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Initial Source
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (1)
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Journal Impact Factor
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Most Recent
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Nanoscale
Metal-organic framework-based nanoplatforms for synergistic anti-atherosclerosis therapy by regulating the PI3K/AKT/MSR1 pathway in macrophages. [Abstract]2025 Feb 6;17(6):3071-3085. PMID: 39704073
Thiamine pyrophosphate purchased from MedChemExpress. Usage Cited in: Nanoscale. 2025 Feb 6;17(6):3071-3085. [Abstract]
Thiamine pyrophosphate (TPP; 21.84 μg/mL) significantly decreased the relative amount of Dil-OxLDL phagocytozed in RAW264.7 cells.
Thiamine pyrophosphate purchased from MedChemExpress. Usage Cited in: Nanoscale. 2025 Feb 6;17(6):3071-3085. [Abstract]
Thiamine pyrophosphate (TPP; 21.84 μg/mL) significantly decreased the protein expression of MSR1 and phosphorylated PI3K p55 to PI3K p85 and the ratio of phosphorylated AKT to AKT in RAW264.7 cells.
Thiamine pyrophosphate purchased from MedChemExpress. Usage Cited in: Nanoscale. 2025 Feb 6;17(6):3071-3085. [Abstract]
Thiamine pyrophosphate (TPP; 60 μg/g; IV; twice a week for 4 weeks) decreased relative plaque areas in the carotid arteries and the Oil Red O-positive plaque areas in Western diet-fed ApoE−/− mice.
Thiamine pyrophosphate purchased from MedChemExpress. Usage Cited in: Nanoscale. 2025 Feb 6;17(6):3071-3085. [Abstract]
Thiamine pyrophosphate (TPP; 60 μg/g; IV; twice a week for 4 weeks) decreased the relative intensities of F4/80 and relative number of macrophages in Western diet-fed ApoE−/− mice.(A) Representative images of immunofluorescence staining of macrophage-associated marker F4/80 and smooth muscle cell-associated marker α-SMA.(B)Relative intensity of F4/80 in plaques of the carotid arteries. (C) Relative number of macrophages in plaques of the carotid arteries.
Thiamine pyrophosphate purchased from MedChemExpress. Usage Cited in: Nanoscale. 2025 Feb 6;17(6):3071-3085. [Abstract]
Thiamine pyrophosphate (TPP; 60 μg/g; IV; twice a week for 4 weeks) showed the concentration of TPP in serum of TPP-treated mice was significantly higher than that in NS-treated, ZIF-8-treated and ZIF-8@TPP-treated micein; no significant difference between all groups with regard to concentrations of alanine transaminase (ALT), aspartate transaminase (AST), total bilirubin (T-BIL), urea and creatinine (CRE) in serum in Western diet-fed ApoE−/− mice.
Thiamine pyrophosphate purchased from MedChemExpress. Usage Cited in: Nanoscale. 2025 Feb 6;17(6):3071-3085. [Abstract]
Thiamine pyrophosphate (TPP; 60 μg/g; IV; twice a week for 4 weeks) showed no obvious pathological changes (e.g., necrosis, fibrosis and atrophy) were observed in vital organs (heart, liver, spleen, lungs and kidneys) in Western diet-fed ApoE−/− mice.
Solvente y solubilidad
In Vitro:
H2O : 41.67 mg/mL (90.44 mM; Need ultrasonic)
DMSO : < 1 mg/mL (insoluble or slightly soluble)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 50 mg/mL (108.51 mM); Clear solution; Need ultrasonic
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
Pureza y Documentación
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Ficha de datos (275 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Demiryilmaz I, et al. A comparative investigation of biochemical and histopathological effects of thiamine and thiamine pyrophosphate on ischemia-reperfusion induced oxidative damage in rat ovarian tissue. Arch Pharm Res. 2013 Sep;36(9):1133-9. [Content Brief]
[2]. Coskun R, et al. The protective effect of thiamine pyrophosphate, but not thiamine, against cardiotoxicity induced with cisplatin in rats. Drug Chem Toxicol. 2014 Jul;37(3):290-4. [Content Brief]
[3]. de Jong L, et al. Thiamine pyrophosphate biosynthesis and transport in the nematode Caenorhabditis elegans. Genetics. 2004 Oct;168(2):845-54. [Content Brief]
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Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 2.1703 mL | 10.8514 mL | 21.7028 mL | 54.2570 mL |
| 5 mM | 0.4341 mL | 2.1703 mL | 4.3406 mL | 10.8514 mL | |
| 10 mM | 0.2170 mL | 1.0851 mL | 2.1703 mL | 5.4257 mL | |
| 15 mM | 0.1447 mL | 0.7234 mL | 1.4469 mL | 3.6171 mL | |
| 20 mM | 0.1085 mL | 0.5426 mL | 1.0851 mL | 2.7129 mL | |
| 25 mM | 0.0868 mL | 0.4341 mL | 0.8681 mL | 2.1703 mL | |
| 30 mM | 0.0723 mL | 0.3617 mL | 0.7234 mL | 1.8086 mL | |
| 40 mM | 0.0543 mL | 0.2713 mL | 0.5426 mL | 1.3564 mL | |
| 50 mM | 0.0434 mL | 0.2170 mL | 0.4341 mL | 1.0851 mL | |
| 60 mM | 0.0362 mL | 0.1809 mL | 0.3617 mL | 0.9043 mL | |
| 80 mM | 0.0271 mL | 0.1356 mL | 0.2713 mL | 0.6782 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Thiamine pyrophosphate Related Classifications
HY-113076 Related Classifications
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