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Thiamine pyrophosphate

(Synonyms: Cocarboxylase)
1 Cited Publications
고객리뷰

Based on 1 publication(s) in Google Scholar

Thiamine pyrophosphate is the coenzyme form of Vitamin B1, and is a required intermediate in the pyruvate dehydrogenase complex and the ketoglutarate dehydrogenase complex. Thiamine pyrophosphate is necessary for oxidative phosphorylation and the pentose phosphate pathway by acting as a cofactor for α-ketoacid dehydrogenases.

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  • Purity: 99.93%
  • CAS No.: 154-87-0
  • 화학식: C12H19ClN4O7P2S
  • 분자량:460.77
  • 보관:

    -20°C, sealed storage, away from moisture

    * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

  • Thiamine pyrophosphate Chemical Structure
    Thiamine pyrophosphate Chemical Structure
  • Experimental Validation Results for Thiamine pyrophosphate
  • Experimental Validation Results for Thiamine pyrophosphate
  • Experimental Validation Results for Thiamine pyrophosphate
  • Experimental Validation Results for Thiamine pyrophosphate
  • Experimental Validation Results for Thiamine pyrophosphate
  • Experimental Validation Results for Thiamine pyrophosphate
CAS No.: 154-87-0
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  • Thiamine pyrophosphate Chemical Structure
    Thiamine pyrophosphate Chemical Structure
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  • 1/16

    Thiamine pyrophosphate purchased from MedChemExpress. Usage Cited in: Nanoscale. 2025 Feb 6;17(6):3071-3085. [Abstract]

    Customer Validation
     Thiamine pyrophosphate (TPP; 21.84 μg/mL) significantly decreased the relative amount of Dil-OxLDL phagocytozed in RAW264.7 cells.

  • 1/16

    Thiamine pyrophosphate purchased from MedChemExpress. Usage Cited in: Nanoscale. 2025 Feb 6;17(6):3071-3085. [Abstract]

    Customer Validation
     Thiamine pyrophosphate (TPP; 21.84 μg/mL) significantly decreased the protein expression of MSR1 and phosphorylated PI3K p55 to PI3K p85 and the ratio of phosphorylated AKT to AKT in RAW264.7 cells.

  • 1/16

    Thiamine pyrophosphate purchased from MedChemExpress. Usage Cited in: Nanoscale. 2025 Feb 6;17(6):3071-3085. [Abstract]

    Customer Validation
     Thiamine pyrophosphate (TPP; 60 μg/g; IV; twice a week for 4 weeks) decreased relative plaque areas in the carotid arteries and the Oil Red O-positive plaque areas in Western diet-fed ApoE−/− mice.

  • 1/16

    Thiamine pyrophosphate purchased from MedChemExpress. Usage Cited in: Nanoscale. 2025 Feb 6;17(6):3071-3085. [Abstract]

    Customer Validation
     Thiamine pyrophosphate (TPP; 60 μg/g; IV; twice a week for 4 weeks) decreased the relative intensities of F4/80 and relative number of macrophages in Western diet-fed ApoE−/− mice.(A) Representative images of immunofluorescence staining of macrophage-associated marker F4/80 and smooth muscle cell-associated marker α-SMA.(B)Relative intensity of F4/80 in plaques of the carotid arteries. (C) Relative number of macrophages in plaques of the carotid arteries.

  • 1/16

    Thiamine pyrophosphate purchased from MedChemExpress. Usage Cited in: Nanoscale. 2025 Feb 6;17(6):3071-3085. [Abstract]

    Customer Validation
     Thiamine pyrophosphate (TPP; 60 μg/g; IV; twice a week for 4 weeks) showed the concentration of TPP in serum of TPP-treated mice was significantly higher than that in NS-treated, ZIF-8-treated and ZIF-8@TPP-treated micein; no significant difference between all groups with regard to concentrations of alanine transaminase (ALT), aspartate transaminase (AST), total bilirubin (T-BIL), urea and creatinine (CRE) in serum in Western diet-fed ApoE−/− mice.

  • 1/16

    Thiamine pyrophosphate purchased from MedChemExpress. Usage Cited in: Nanoscale. 2025 Feb 6;17(6):3071-3085. [Abstract]

    Customer Validation
     Thiamine pyrophosphate (TPP; 60 μg/g; IV; twice a week for 4 weeks) showed no obvious pathological changes (e.g., necrosis, fibrosis and atrophy) were observed in vital organs (heart, liver, spleen, lungs and kidneys) in Western diet-fed ApoE−/− mice.

  • Thiamine pyrophosphate