154-87-0
154-87-0
Chemical Structure
Thiamine pyrophosphate
Synonym(s): Cocarboxylase
- CAS No.: 154-87-0
- Formula:C12H19ClN4O7P2S
- Molecular Weight:460.77
IUPAC Name: 3-((4-amino-2-methylpyrimidin-5-yl)methyl)-5-(2-((hydroxy(phosphonooxy)phosphoryl)oxy)ethyl)-4-methylthiazol-3-ium chloride
InChIKey: YXVCLPJQTZXJLH-UHFFFAOYSA-N
SMILES: OP(OP(OCCC1=C(C)[N+](CC2=CN=C(C)N=C2N)=CS1)(O)=O)(O)=O.[Cl-]
Biological Activity: Thiamine pyrophosphate is the coenzyme form of Vitamin B1, and is a required intermediate in the pyruvate dehydrogenase complex and the ketoglutarate dehydrogenase complex. Thiamine pyrophosphate is necessary for oxidative phosphorylation and the pentose phosphate pathway by acting as a cofactor for α-ketoacid dehydrogenases[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Thiamine pyrophosphate | 99.93% | Thiamine pyrophosphate is the coenzyme form of Vitamin B1, and is a required intermediate in the pyruvate dehydrogenase complex and the ketoglutarate dehydrogenase complex. Thiamine pyrophosphate is necessary for oxidative phosphorylation and the pentose phosphate pathway by acting as a cofactor for α-ketoacid dehydrogenases. | ||||||||||||||||||||
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Thiamine pyrophosphate (Standard) | 98.40% | Thiamine pyrophosphate (Standard) is the analytical standard of Thiamine pyrophosphate. This product is intended for research and analytical applications. Thiamine pyrophosphate is the coenzyme form of Vitamin B1, and is a required intermediate in the pyruvate dehydrogenase complex and the ketoglutarate dehydrogenase complex. Thiamine pyrophosphate is necessary for oxidative phosphorylation and the pentose phosphate pathway by acting as a cofactor for α-ketoacid dehydrogenases. | ||||||||||||||||||||
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Thiamine pyrophosphate-d3 | 97.31% | Thiamine pyrophosphate-d3 is the deuterium labeled Thiamine pyrophosphate. Thiamine pyrophosphate is the coenzyme form of Vitamin B1 and is a required intermediate in the pyruvate dehydrogenase complex and the ketoglutarate dehydrogenase complex. | ||||||||||||||||||||
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Oxythiamine chloride hydrochloride (Standard) | ≥98% | Oxythiamine chloride hydrochloride (Standard) is the analytical standard of Oxythiamine chloride hydrochloride (HY-107430A). This product is intended for research and analytical applications. Oxythiamine (Hydroxythiamine) chloride hydrochloride, an analogue of anti-metabolite, can suppress the non-oxidative synthesis of ribose and induce cell apoptosis. Oxythiamine chloride hydrochloride is a thiamine antagonist and inhibits transketolase (TK). Oxythiamine chloride hydrochloride inhibits cancer cell apoptosis and inhibits cell proliferation. | ||||||||||||||||||||
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Oxythiamine diphosphate | Oxythiamin diphosphate is a potent transketolase (TK) inhibitor. | |||||||||||||||||||||
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N3PT | 98.63% | N3PT (N3-pyridyl thiamine) is a potent and selective transketolase inhibitor. N3PT is pyrophosphorylated and then binds to transketolase with an Kd value of 22 nM (Apo-TK, transketolase lacking bound thiamine). | ||||||||||||||||||||
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Thiamine monochloride | 99.96% | Thiamine monochloride (Vitamin B1) is an essential vitamin that plays an important role in cellular production of energy from ingested food and enhances normal neuronal actives. | ||||||||||||||||||||
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Thiamine monochloride (Standard) | 99.38% | Thiamine monochloride (Standard) (Vitamin B1 (Standard)) is the analytical standard of Thiamine monochloride (HY-A0100). This product is intended for research and analytical applications. Thiamine monochloride (Vitamin B1) is an essential vitamin that plays an important role in cellular production of energy from ingested food and enhances normal neuronal actives. | ||||||||||||||||||||
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Vitamin B1 monophosphate chloride | 99.27% | Vitamin B1 monophosphate (Thiamine monophosphate) chloride is a source of vitamin B1 and can be used in food supplements to enhance nutrition. | ||||||||||||||||||||
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Vitamin B1 monophosphate chloride (Standard) | ≥98% | Vitamin B1 monophosphate (chloride) (Standard) is the analytical standard of Vitamin B1 monophosphate (chloride). This product is intended for research and analytical applications. Vitamin B1 monophosphate (Thiamine monophosphate) chloride is a source of vitamin B1 and can be used in food supplements to enhance nutrition. | ||||||||||||||||||||
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Thiamine nitrate | 99.84% | Thiamine nitrate is an essential vitamin which can enhance normal neuronal actives. | ||||||||||||||||||||
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Thiamine nitrate (Standard) | ≥98% | Thiamine nitrate (Standard) is the analytical standard of Thiamine nitrate. This product is intended for research and analytical applications. Thiamine nitrate is an essential vitamin which can enhance normal neuronal actives. | ||||||||||||||||||||
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Thiamine hydrochloride (Standard) | 99.84% | Thiamine (hydrochloride) (Standard) is the analytical standard of Thiamine (hydrochloride). This product is intended for research and analytical applications. Thiamine hydrochloride (Thiamine chloride hydrochloride) is an essential micronutrient needed as a cofactor for many central metabolic enzymes. | ||||||||||||||||||||
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Thiamine monochloride-13C4 hydrochloride | 98.39% | Thiamine monochloride-13C4 (hydrochloride) is the deuterium labeled Thiamine hydrochloride. Thiamine hydrochloride (Thiamine chloride hydrochloride) is an essential micronutrient needed as a cofactor for many central metabolic enzymes. | ||||||||||||||||||||
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Thiamine triphosphoric acid ester | Thiamine triphosphoric acid ester (Thiamine triphosphate) is a neuroactive compound and a triphosphate derivative of vitamin thiamine. Thiamine triphosphoric acid ester exists in microorganisms, animal organs and plants. In E. coli, Thiamine triphosphoric acid ester is transiently produced under amino acid deficiency, while in mammalian cells, it is continuously produced at a low rate. Thiamine triphosphoric acid ester can be synthesized by two distinct enzymes (cytosolic AK1 and FoF1-ATP synthase in brain mitochondria). Thiamine triphosphoric acid ester plays a fundamental role in cellular metabolism or cellular signal transduction. | |||||||||||||||||||||
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References
- [1]. Demiryilmaz I, et al. A comparative investigation of biochemical and histopathological effects of thiamine and thiamine pyrophosphate on ischemia-reperfusion induced oxidative damage in rat ovarian tissue. Arch Pharm Res. 2013 Sep;36(9):1133-9. [Content Brief]
- [2]. Coskun R, et al. The protective effect of thiamine pyrophosphate, but not thiamine, against cardiotoxicity induced with cisplatin in rats. Drug Chem Toxicol. 2014 Jul;37(3):290-4. [Content Brief]
- [3]. de Jong L, et al. Thiamine pyrophosphate biosynthesis and transport in the nematode Caenorhabditis elegans. Genetics. 2004 Oct;168(2):845-54. [Content Brief]
