Thiamine triphosphoric acid ester
Thiamine triphosphoric acid ester (Thiamine triphosphate) is a neuroactive compound and a triphosphate derivative of vitamin thiamine. Thiamine triphosphoric acid ester exists in microorganisms, animal organs and plants. In E. coli, Thiamine triphosphoric acid ester is transiently produced under amino acid deficiency, while in mammalian cells, it is continuously produced at a low rate. Thiamine triphosphoric acid ester can be synthesized by two distinct enzymes (cytosolic AK1 and FoF1-ATP synthase in brain mitochondria). Thiamine triphosphoric acid ester plays a fundamental role in cellular metabolism or cellular signal transduction.
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- CAS No.: 3475-65-8
- Formula: C12H19N4O10P3S
- Molecular Weight:504.29
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Thiamine triphosphate (1-10 μM) activates a large unitary conductance anion channel in inside-out patches of mouse neuroblastoma cells[2].
Thiamine triphosphate acts as a phosphate donor to phosphorylate rapsyn from Torpedo marmorata electric organ on histidyl residues, as well as unidentified proteins in rodent brain[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3475-65-8
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Molecular Weight 504.29
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Formula C12H19N4O10P3S
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SMILES
O=P(O)(OP(O)(OP([O-])(OCCC1=C(C)[N+](CC2=CN=C(C)N=C2N)=CS1)=O)=O)O
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Synonyms
Thiamine triphosphate
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Makarchikov AF, et al. Thiamine triphosphate and thiamine triphosphatase activities: from bacteria to mammals. Cell Mol Life Sci. 2003;60(7):1477-1488. [Content Brief]
[2]. Bettendorff L, et al. Thiamine triphosphate: a ubiquitous molecule in search of a physiological role. Metab Brain Dis. 2014;29(4):1069-1082. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Thiamine triphosphoric acid ester Related Classifications
HY-W587827 Related Classifications
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