Thiamine triphosphoric acid ester  (Synonyms: Thiamine triphosphate)

Thiamine triphosphoric acid ester (Thiamine triphosphate) is a neuroactive compound and a triphosphate derivative of vitamin thiamine. Thiamine triphosphoric acid ester exists in microorganisms, animal organs and plants. In E. coli, Thiamine triphosphoric acid ester is transiently produced under amino acid deficiency, while in mammalian cells, it is continuously produced at a low rate. Thiamine triphosphoric acid ester can be synthesized by two distinct enzymes (cytosolic AK1 and FoF1-ATP synthase in brain mitochondria). Thiamine triphosphoric acid ester plays a fundamental role in cellular metabolism or cellular signal transduction^[1][2].

Thiamine triphosphate (¹-10 μM) activates a large unitary conductance anion channel in inside-out patches of mouse neuroblastoma cells^[2].
Thiamine triphosphate acts as a phosphate donor to phosphorylate rapsyn from Torpedo marmorata electric organ on histidyl residues, as well as unidentified proteins in rodent brain^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

504.29

C₁₂H₁₉N₄O₁₀P₃S

3475-65-8

O=P(O)(OP(O)(OP([O-])(OCCC1=C(C)[N+](CC2=CN=C(C)N=C2N)=CS1)=O)=O)O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Makarchikov AF, et al. Thiamine triphosphate and thiamine triphosphatase activities: from bacteria to mammals. Cell Mol Life Sci. 2003;60(7):1477-1488.  [Content Brief]

  [2]. Bettendorff L, et al. Thiamine triphosphate: a ubiquitous molecule in search of a physiological role. Metab Brain Dis. 2014;29(4):1069-1082.  [Content Brief]