Thiamine triphosphoric acid ester
Thiamine triphosphoric acid ester (Thiamine triphosphate) is a neuroactive compound and a triphosphate derivative of vitamin thiamine. Thiamine triphosphoric acid ester exists in microorganisms, animal organs and plants. In E. coli, Thiamine triphosphoric acid ester is transiently produced under amino acid deficiency, while in mammalian cells, it is continuously produced at a low rate. Thiamine triphosphoric acid ester can be synthesized by two distinct enzymes (cytosolic AK1 and FoF1-ATP synthase in brain mitochondria). Thiamine triphosphoric acid ester plays a fundamental role in cellular metabolism or cellular signal transduction.
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- CAS No.: 3475-65-8
- Formule: C12H19N4O10P3S
- Masse moléculaire:504.29
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Activité biologique
Description
In Vitro
Thiamine triphosphate (1-10 μM) activates a large unitary conductance anion channel in inside-out patches of mouse neuroblastoma cells[2].
Thiamine triphosphate acts as a phosphate donor to phosphorylate rapsyn from Torpedo marmorata electric organ on histidyl residues, as well as unidentified proteins in rodent brain[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
Chemical Information
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CAS No. 3475-65-8
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Masse moléculaire 504.29
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Formule C12H19N4O10P3S
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SMILES
O=P(O)(OP(O)(OP([O-])(OCCC1=C(C)[N+](CC2=CN=C(C)N=C2N)=CS1)=O)=O)O
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Synonyms
Thiamine triphosphate
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Makarchikov AF, et al. Thiamine triphosphate and thiamine triphosphatase activities: from bacteria to mammals. Cell Mol Life Sci. 2003;60(7):1477-1488. [Content Brief]
[2]. Bettendorff L, et al. Thiamine triphosphate: a ubiquitous molecule in search of a physiological role. Metab Brain Dis. 2014;29(4):1069-1082. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Thiamine triphosphoric acid ester Related Classifications
HY-W587827 Related Classifications
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