S-Acetonyl-CoA
S-Acetonyl-CoA (Acetonyl-coenzyme A) is a non-reactive structural analog of acetyl-CoA that acts as a competitive inhibitor against multiple target enzymes. S-Acetonyl-CoA lacks the characteristic thioester group of acetyl-CoA, retaining only a thioether structure. S-Acetonyl-CoA competes with acetyl-CoA for binding to citrate synthase, phosphate transacetylase, carnitine acetyltransferase, and N-myristoyltransferase 1. S-Acetonyl-CoA serves as a reagent for investigating acetyl-CoA-dependent physiological processes.
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- CAS No.: 75179-85-0
- Formula: C24H40N7O17P3S
- Molecular Weight:823.60
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
S-Acetonyl-CoA (Acetonyl-CoA) (10-40 μmol/liter; 30 min) potently competes with acetyl-CoA for binding to porcine heart citrate synthase (Ki = 8.8 μmol/liter), but does not undergo the condensation reaction catalyzed by this enzyme[1].
S-Acetonyl-CoA (0-200 μmol/liter) competitively inhibits phosphotransacetylase from *Escherichia coli* and carnitine acetyltransferase from pigeon breast muscle, with Ki values of 125 μmol/liter and 152 μmol/liter, respectively[1].
S-Acetonyl-CoA exhibited a competitive inhibitory effect on human N-myristyltransferase 1, with a Ki of 10.1 μM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 75179-85-0
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Molecular Weight 823.60
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Formula C24H40N7O17P3S
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SMILES
NC1=C(C2=NC=N1)N=CN2[C@@H]3O[C@H](COP(OP(OCC(C)(C)[C@@H](O)C(NCCC(NCCSCC(C)=O)=O)=O)(O)=O)(O)=O)[C@@H](OP(O)(O)=O)[C@H]3O
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Synonyms
Acetonyl-coenzyme A
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
S-Acetonyl-CoA Related Classifications
HY-E70394 Related Classifications
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- S-Acetonyl-CoA
- 75179-85-0
- Acetonyl-coenzyme A
- Biochemical Assay Reagents
- N-myristoyltransferase
- pig heart citrate synthase
- pig citrate synthase
- oxaloacetate
- pigeon carnitine acetyltransferase
- acetyl-CoA
- Escherichia coli phosphoenolpyruvate carboxylase
- rat liver pyruvate carboxylase
- pigeon breast muscle carnitine acetyltransferase
- Escherichia coli phosphotransacetylase
- human N-myristoyltransferase 1
- Inhibitor
- inhibitor
- inhibit