S-Acetonyl-CoA  (Synonyms: Acetonyl-coenzyme A)

S-Acetonyl-CoA (Acetonyl-coenzyme A) is a non-reactive structural analog of acetyl-CoA that acts as a competitive inhibitor against multiple target enzymes. S-Acetonyl-CoA lacks the characteristic thioester group of acetyl-CoA, retaining only a thioether structure. S-Acetonyl-CoA competes with acetyl-CoA for binding to citrate synthase, phosphate transacetylase, carnitine acetyltransferase, and N-myristoyltransferase 1. S-Acetonyl-CoA serves as a reagent for investigating acetyl-CoA-dependent physiological processes^[1].

S-Acetonyl-CoA (Acetonyl-CoA) (10-40 μmol/liter; 30 min) potently competes with acetyl-CoA for binding to porcine heart citrate synthase (K_i = 8.8 μmol/liter), but does not undergo the condensation reaction catalyzed by this enzyme^[1].
S-Acetonyl-CoA (0-200 μmol/liter) competitively inhibits phosphotransacetylase from *Escherichia coli* and carnitine acetyltransferase from pigeon breast muscle, with K_i values of 125 μmol/liter and 152 μmol/liter, respectively^[1].
S-Acetonyl-CoA exhibited a competitive inhibitory effect on human N-myristyltransferase 1, with a K_i of 10.1 μM^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

C₂₄H₄₀N₇O₁₇P₃S

75179-85-0

NC1=C(C2=NC=N1)N=CN2[C@@H]3O[C@H](COP(OP(OCC(C)(C)[C@@H](O)C(NCCC(NCCSCC(C)=O)=O)=O)(O)=O)(O)=O)[C@@H](OP(O)(O)=O)[C@H]3O

823.60

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Rubenstein P. S-acetonyl-CoA. A nonreactive analog of acetyl-CoA. J Biol Chem. 1980 Aug 25;255(16):7858-7862.

  [2]. Su D, et al. Binding Affinity Determines Substrate Specificity and Enables Discovery of Substrates for N-Myristoyltransferases. ACS Catal. 2021;11(24):14877-14883.