PCB Antibody (YA2060)
(Synonyms: PC; Pyruvate carboxylase; mitochondrial; Pyruvic carboxylase; PCB)
Based on 1 Customer Validation
PCB Antibody (YA2060) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PCB.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, ICC/IF
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in rabbit IgG in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
|---|---|---|
| Dilution Ratio | 1:1000-1:2000 | 1:50-1:200 |
Product Details
PCB Antibody (YA2060) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PCB.
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Host Rabbit
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Clonality Recombinant,Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 130 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 130 kDa
Entrez Gene: 5091 Human ; 25104 Rat
SwissProt: P11498 Human ; Q05920 Mouse ; P52873 Rat
OMIM: 266150 Human
A synthesized peptide derived from human PCB aa7-64.
Endogenous
Affinity Chromatography
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in rabbit IgG in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
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Concentration
Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
PCB is a Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. Catalyzes in a tissue specific manner, the initial reactions of glucose (liver, kidney) and lipid (adipose tissue, liver, brain) synthesis from pyruvate
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Subcellular Localization
Mitochondrion matrix
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Isoforms & Post-Translational Modification
P11498 has 2 isomers: P11498-1: 129634 Da (predicted); P11498-2: 57925 Da (predicted).
Acetylation of Lys-748 might play a role in catalytic activity regulation -
Subunit
Homotetramer (PubMed:18297087). Interacts (via the biotin carboxylation domain) with SIRT4 (PubMed:23438705)
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SwissProt ID
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Synonyms
PC; Pyruvate carboxylase; mitochondrial; Pyruvic carboxylase; PCB
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Research Field
Signal Transduction
Documentation
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