Search Result

Results for "

type-II

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5 alpha Reductase (4) AMPK (2) Amylases (1) Amylin Receptor (1) Antibiotic (7) Apoptosis (10) Autophagy (4) Bacterial (12) Bcr-Abl (6) Biochemical Assay Reagents (8) BMX Kinase (1) c-Fms (3) c-Kit (2) c-Met/HGFR (1) Calcium Channel (2) CaMK (2) CD20 (1) CDK (2) DNA/RNA Synthesis (3) Drug Metabolite (1) Endogenous Metabolite (3) FGFR (1) FLT3 (2) Free Fatty Acid Receptor (5) Fungal (1) Glucosidase (3) GnRH Receptor (2) HBV (1) HCV (1) HSV (1) Interleukin Related (2) IRAK (1) Isotope-Labeled Compounds (2) JAK (2) Ligands for Target Protein for PROTAC (1) Lipoxygenase (1) MAGL (1) mGluR (1) Mitochondrial Metabolism (1) MMP (1) nAChR (2) Nuclear Hormone Receptor 4A/NR4A (1) p38 MAPK (2) PACAP Receptor (4) Parasite (2) PDGFR (3) Phosphatase (1) Phosphodiesterase (PDE) (1) PKC (1) PPAR (3) Prostaglandin Receptor (1) Raf (2) Reactive Oxygen Species (3) RET (1) RIP kinase (2) SARS-CoV (1) Ser/Thr Protease (2) SGLT (1) Sodium Channel (2) Src (1) Stearoyl-CoA Desaturase (SCD) (1) TAM Receptor (1) TGF-β Receptor (4) Topoisomerase (12) Trk Receptor (4) TrxR (1) VEGFR (2)
By Research Areas:	Cancer (41) Cardiovascular Disease (2) Endocrinology (4) Infection (22) Inflammation/Immunology (16) Metabolic Disease (28) Neurological Disease (15)

By Targets:

5 alpha Reductase (4)

AMPK (2)

Amylases (1)

Amylin Receptor (1)

Antibiotic (7)

Apoptosis (10)

Autophagy (4)

Bacterial (12)

Bcr-Abl (6)

Biochemical Assay Reagents (8)

BMX Kinase (1)

c-Fms (3)

c-Kit (2)

c-Met/HGFR (1)

Calcium Channel (2)

CaMK (2)

CD20 (1)

CDK (2)

DNA/RNA Synthesis (3)

Drug Metabolite (1)

Endogenous Metabolite (3)

FGFR (1)

FLT3 (2)

Free Fatty Acid Receptor (5)

Fungal (1)

Glucosidase (3)

GnRH Receptor (2)

HBV (1)

HCV (1)

HSV (1)

Interleukin Related (2)

IRAK (1)

Isotope-Labeled Compounds (2)

JAK (2)

Ligands for Target Protein for PROTAC (1)

Lipoxygenase (1)

MAGL (1)

mGluR (1)

Mitochondrial Metabolism (1)

MMP (1)

nAChR (2)

Nuclear Hormone Receptor 4A/NR4A (1)

p38 MAPK (2)

PACAP Receptor (4)

Parasite (2)

PDGFR (3)

Phosphatase (1)

Phosphodiesterase (PDE) (1)

PKC (1)

PPAR (3)

Prostaglandin Receptor (1)

Raf (2)

Reactive Oxygen Species (3)

RET (1)

RIP kinase (2)

SARS-CoV (1)

Ser/Thr Protease (2)

SGLT (1)

Sodium Channel (2)

Src (1)

Stearoyl-CoA Desaturase (SCD) (1)

TAM Receptor (1)

TGF-β Receptor (4)

Topoisomerase (12)

Trk Receptor (4)

TrxR (1)

VEGFR (2)

By Research Areas:

Cancer (41)

Cardiovascular Disease (2)

Endocrinology (4)

Infection (22)

Inflammation/Immunology (16)

Metabolic Disease (28)

Neurological Disease (15)

123

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Targets Recommended: Photosystem II CD74

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-E70005B

Collagenase, Type II	MMP	Others
Collagenase, Type II is a microbially derived matrix metalloproteinases (MMPs) and zinc peptidase. Collagenase, Type II breaksdown collagens1, 3, 5, 7, 8, 10, fibronectin, gelatin, aggrecann .

HY-150044

Type II topoisomerase inhibitor 1	DNA/RNA Synthesis Topoisomerase Bacterial	Infection
Type II topoisomerase inhibitor 1 is a potent and selective E. coli DNA gyrase inhibitor (IC₅₀: 1.7 nM), and forms hydrogen bonds with Asp73 residue. Type II topoisomerase inhibitor 1 inhibits topoisomerase IV activity (IC₅₀: 0.98 μM). Type II topoisomerase inhibitor 1 can be used in the research of antibacterial area .

HY-163004

Type II TRK inhibitor 2	Trk Receptor	Cancer
Type II TRK inhibitor 2 (compound 40l) is a selective type II TRK inhibitor with plasma stability and moderate hepatic microsomal stability. Type II TRK inhibitor 2 significantly inhibits Km-12, Ba/F3-TRKA ^G595R and Ba/F3-TRKA ^G667C cell proliferation (IC₅₀: 4.1 nM, 41.5 nM, 1.4 nM). Type II TRK inhibitor 2 can be used to study NTRK fusion cancers .

HY-146807

Type II TRK inhibitor 1	Trk Receptor	Cancer
Type II TRK inhibitor 1 is a potent TRK inhibitor, which inhibits various TRK fusion protein variants and wild type. Type II TRK inhibitor 1 exhibits antiproliferative activity against Ba/F3 cells harboring CD74-TRKA ^G667C and ETV6-TRKC ^G696C fusion proteins with IC₅₀s of 6 nM and 1.7 nM, respectively . Type II TRK inhibitor 1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-154972

α-Amylase/α-Glucosidase-IN-3	Glucosidase Amylases	Metabolic Disease
α-Amylase/α-Glucosidase-IN-3 (Compound 17) is an α-Amylase/α-Glucosidase dual inhibitor, with IC₅₀s of 0.70 μM and 1.10 μM. α-Amylase/α-Glucosidase-IN-3 can be used for research of type-II diabetes mellitus .

HY-P5003

*Collagen Type II* Fragment**	Biochemical Assay Reagents	Inflammation/Immunology
Collagen Type II Fragment is an anti-inflammatory peptide that potently inhibits collagen-induced arthritis (CIA) in mice. Collagen Type II Fragment can be used for research on inflammation and immunity .

HY-P9910

Obinutuzumab GA101; Anti-Human CD20 type II, Humanized Antibody	CD20	Cancer
Obinutuzumab (GA101) a novel glycoengineered Type II CD20 humanized IgG1 monoclonal antibody in development for non-Hodgkin lymphoma.

HY-10326

GW788388 10+ Cited Publications	TGF-β Receptor	Cancer
GW788388 is a potent and selective inhibitor of ALK5 with IC₅₀ of 18 nM, and also inhibits TGF-β type II receptor and activin type II receptor activities, without inhibiting BMP type II receptor.

HY-A0104J

*HPMC (Type II,Viscosity:5mPa.s)* Hypromellose (type II,Viscosity:5mPa.s); (Hydroxypropyl)methyl cellulose (type II,Viscosity:5mPa.s); Celacol HPM 5000 (type II,Viscosity:5mPa.s)	Biochemical Assay Reagents	Others
HPMC (Hypromellose) (Type II,Viscosity:5mPa.s) is a hydrophilic, non-ionic cellulose ether used to form swellable-soluble matrices. HPMC (Type II,Viscosity:5mPa.s) is widely used in agent formulations due to its biocompatibility, uncharged nature, solubility in water and thermoplastic behavior .

HY-A0104I

*HPMC (Type II,Viscosity:100000mPa.s)* Hypromellose (type II,Viscosity:100000mPa.s); (Hydroxypropyl)methyl cellulose (type II,Viscosity:100000mPa.s); Celacol HPM 5000 (type II,Viscosity:100000mPa.s)	Biochemical Assay Reagents	Others
Hydroxypropylmethylcellulose (Type II,Viscosity:100000mPa.s) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-A0104E

*HPMC (Type II,Viscosity:100mPa.s)* Hypromellose (type II,Viscosity:100mPa.s); (Hydroxypropyl)methyl cellulose (type II,Viscosity:100mPa.s); Celacol HPM 5000 (type II,Viscosity:100mPa.s)	Biochemical Assay Reagents	Others
Hypromellose (Type II,Viscosity:100mPa.s) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-A0104H

*HPMC (Type II,Viscosity:15000mPa.s)* Hypromellose (type II,Viscosity:15000mPa.s); (Hydroxypropyl)methyl cellulose (type II,Viscosity:15000mPa.s); Celacol HPM 5000 (type II,Viscosity:15000mPa.s)	Biochemical Assay Reagents	Others
Hypromellose (Type II,Viscosity:15000mPa.s) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-A0104F

*HPMC (Type II,Viscosity:400mPa.s)* Hypromellose (type II,Viscosity:400mPa.s); (Hydroxypropyl)methyl cellulose (type II,Viscosity:400mPa.s); Celacol HPM 5000 (type II,Viscosity:400mPa.s)	Biochemical Assay Reagents	Others
Hypromellose (Type II,Viscosity:400mPa.s) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-A0104G

*HPMC (Type II,Viscosity:4000mPa.s)* Hypromellose (type II,Viscosity:4000mPa.s); (Hydroxypropyl)methyl cellulose (type II,Viscosity:4000mPa.s); Celacol HPM 5000 (type II,Viscosity:4000mPa.s)	Biochemical Assay Reagents	Others
Hypromellose (Type II,Viscosity:4000mPa.s) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-P0220

PACAP (6-38), human, ovine, rat	PACAP Receptor	Neurological Disease
PACAP (6-38), human, ovine, rat is a potent PACAP receptor antagonist with IC₅₀s of 30, 600, and 40 nM for *PACAP type* I receptor, PACAP type II receptor VIP₁, and PACAP type II receptor VIP₂**, respectively.

HY-16742

Gepotidacin

5+ Cited Publications

GSK2140944
Bacterial Topoisomerase Infection

Gepotidacin (GSK2140944) is a novel triazaacenaphthylene bacterial type II topoisomerase inhibitor.
HY-110304

NPEC-caged-LY379268

mGluR Neurological Disease

NPEC-caged-LY379268 is a type II mGluR agonist .

Gepotidacin 5+ Cited Publications GSK2140944	Bacterial Topoisomerase	Infection
Gepotidacin (GSK2140944) is a novel triazaacenaphthylene bacterial type II topoisomerase inhibitor.

NPEC-caged-LY379268	mGluR	Neurological Disease
NPEC-caged-LY379268 is a type II mGluR agonist .

HY-P0220A

PACAP (6-38), human, ovine, rat TFA 1 Publications Verification	PACAP Receptor	Neurological Disease
PACAP (6-38), human, ovine, rat TFA is a potent PACAP receptor antagonist with IC₅₀s of 30, 600, and 40 nM for *PACAP type* I receptor, PACAP type II receptor VIP₁, and PACAP type II receptor VIP₂**, respectively.

HY-114632

Oxeglitazar

Others Metabolic Disease

Oxeglitazar is an orally active compound that can be used for the research of type II diabetes .

Oxeglitazar	Others	Metabolic Disease
Oxeglitazar is an orally active compound that can be used for the research of type II diabetes .

HY-P0221

PACAP (1-38), human, ovine, rat 3 Publications Verification Pituitary Adenylate Cyclase Activating Polypeptide 38	PACAP Receptor	Neurological Disease
PACAP (1-38), human, ovine, rat is a neuropeptide with 38 amino acid residues. PACAP (1-38) binds to *PACAP type* I receptor, PACAP type II receptor VIP₁, and PACAP type II receptor VIP₂ with IC₅₀**s of 4 nM, 2 nM, and 1 nM, respectively.

HY-100600

BGG463

K03859

BGG463 (K03859) is an orally active type II CDK2 inhibitor .

BGG463 K03859
BGG463 (K03859) is an orally active type II CDK2 inhibitor .

HY-P0221A

PACAP (1-38), human, ovine, rat TFA Pituitary Adenylate Cyclase Activating Polypeptide 38 TFA	PACAP Receptor	Neurological Disease
PACAP (1-38), human, ovine, rat TFA is a neuropeptide with 38 amino acid residues. PACAP (1-38) binds to *PACAP type* I receptor, PACAP type II receptor VIP₁, and PACAP type II receptor VIP₂ with IC₅₀**s of 4 nM, 2 nM, and 1 nM, respectively.

HY-76938

Actarit 4-Acetylaminophenylacetic acid; MS-932	Others	Inflammation/Immunology
Actarit, an orally active antirheumatic compound, has the potential to treat type II collagen-induced arthritis .

HY-15465

KN-93 Maximum Cited Publications 54 Publications Verification	CaMK Autophagy	Cancer
KN-93 is a cell-permeable, reversible and competitive inhibitor calmodulin-dependent kinase type II (CaMKII) with a K_i of 370 nM.

HY-15465A

KN-93 hydrochloride Maximum Cited Publications 54 Publications Verification	CaMK Autophagy	Cancer
KN-93 hydrochloride is a cell-permeable, reversible and competitive inhibitor calmodulin-dependent kinase type II (CaMKII) with a K_i of 370 nM.

HY-101267

CHMFL-BMX-078 1 Publications Verification CHMFL-BMX 078	BMX Kinase	Cancer
CHMFL-BMX-078 is a highly potent and selective type II irreversible BMX kinase inhibitor with an IC₅₀ of 11 nM.

HY-13635

Finasteride 4 Publications Verification MK-906	5 alpha Reductase	Cancer
Finasteride (MK-906) is a potent and competitive 5α-reductase inhibitor, with an IC₅₀ of 4.2 nM for type II 5α-reductase. Finasteride has approximately a 100-fold greater affinity for type II 5α-reductase enzyme than for the type I enzyme. Finasteride can be used for the research of benign prostatic hyperplasia (BPH) and androgenic alopecia .

HY-13635A

Finasteride acetate MK-906 acetate	5 alpha Reductase	Cancer
Finasteride (MK-906) acetate is a potent and competitive 5α-reductase inhibitor, with an IC₅₀ of 4.2 nM for type II 5α-reductase. Finasteride acetate has approximately a 100-fold greater affinity for type II 5α-reductase enzyme than for the type I enzyme. Finasteride acetate can be used for the research of benign prostatic hyperplasia (BPH) and androgenic alopecia .

HY-19900

ITX5061

2 Publications Verification

p38 MAPK Autophagy HCV Infection

ITX5061 is a type II inhibitor of p38 MAPK and also an antagonist of scavenger receptor B1 (SR-B1).
HY-145985

CBR-3465

Bacterial Infection

CBR-3465 is a mycobacterium tuberculosis (Mtb) type II NADH dehydrogenase inhibitor, with the MIC of 0.16 μM against Mtb .
HY-145986

CBR-6672

Bacterial Infection

CBR-6672 is a mycobacterium tuberculosis (Mtb) type II NADH dehydrogenase inhibitor, with the MIC of 0.14 μM against Mtb .
HY-18960

CHZ868

5 Publications Verification

JAK Cancer

CHZ868 is a type II JAK2 inhibitor with an IC₅₀ of 0.17 μM in EPOR JAK2 WT Ba/F3 cell.

ITX5061 2 Publications Verification	p38 MAPK Autophagy HCV	Infection
ITX5061 is a type II inhibitor of p38 MAPK and also an antagonist of scavenger receptor B1 (SR-B1).

CBR-3465	Bacterial	Infection
CBR-3465 is a mycobacterium tuberculosis (Mtb) type II NADH dehydrogenase inhibitor, with the MIC of 0.16 μM against Mtb .

CBR-6672	Bacterial	Infection
CBR-6672 is a mycobacterium tuberculosis (Mtb) type II NADH dehydrogenase inhibitor, with the MIC of 0.14 μM against Mtb .

CHZ868 5 Publications Verification	JAK	Cancer
CHZ868 is a type II JAK2 inhibitor with an IC₅₀ of 0.17 μM in EPOR JAK2 WT Ba/F3 cell.

HY-N3269

Methyl p-hydroxyphenyllactate	Others	Others
Methyl p-hydroxyphenyllactate (MeHPLA) is an important cell growth-regulating agent which binds to nuclear type II binding sites in normal and malignant cells .

HY-147729

UIAA-II-232

DNA/RNA Synthesis Infection

UIAA-II-232 (compound 19b) is a potent DNA gyrase catalytic inhibitor with an IC₅₀ value of 3.5 µM .

UIAA-II-232	DNA/RNA Synthesis	Infection
UIAA-II-232 (compound 19b) is a potent DNA gyrase catalytic inhibitor with an IC₅₀ value of 3.5 µM .

HY-125857

Cytochrome C	Biochemical Assay Reagents Apoptosis Reactive Oxygen Species	Metabolic Disease
Cytochrome C is a multi-functional enzyme involving in life and death decisions of the cell. Cytochrome C is essential in mitochondrial electron transport and intrinsic type II apoptosis .

HY-13635S

Finasteride-d9 MK-906-d₉	Isotope-Labeled Compounds 5 alpha Reductase	Cancer
Finasteride-d₉ is deuterium labeled Finasteride. Finasteride (MK-906) is a potent and competitive 5α-reductase inhibitor, with an IC50 of 4.2 nM for type II 5α-reductase. Finasteride has approximately a 100-fold greater affinity for type II 5α-reductase enzyme than for the type I enzyme. Finasteride can be used for the research of benign prostatic hyperplasia (BPH) and androgenic alopecia[1][2][3].

HY-13635R

Finasteride (Standard) MK-906 (Standard)	5 alpha Reductase	Cancer
Finasteride (Standard) is the analytical standard of Finasteride. This product is intended for research and analytical applications. Finasteride (MK-906) is a potent and competitive 5α-reductase inhibitor, with an IC₅₀ of 4.2 nM for type II 5α-reductase. Finasteride has approximately a 100-fold greater affinity for type II 5α-reductase enzyme than for the type I enzyme. Finasteride can be used for the research of benign prostatic hyperplasia (BPH) and androgenic alopecia .

HY-16619

AM-5262

Free Fatty Acid Receptor Metabolic Disease

AM-5262 is a GPR40 full agonist with an EC₅₀ value of 0.081 μM. AM-5262 can be used for the research of type II diabetes .
HY-161057

HG-7-86-01

Bcr-Abl Inflammation/Immunology Cancer

HG-7-86-01 (Compound 26) is type II tyrosine kinase inhibitor. HG-7-86-01 has anti-proliferative activity .

AM-5262	Free Fatty Acid Receptor	Metabolic Disease
AM-5262 is a GPR40 full agonist with an EC₅₀ value of 0.081 μM. AM-5262 can be used for the research of type II diabetes .

HG-7-86-01	Bcr-Abl	Inflammation/Immunology Cancer
HG-7-86-01 (Compound 26) is type II tyrosine kinase inhibitor. HG-7-86-01 has anti-proliferative activity .

HY-15004

AUZ 454 4 Publications Verification K03861	CDK	Cancer
AUZ 454 (K03861) is a type II CDK2 inhibitor with K_d of 8.2 nM. AUZ 454 (K03861) inhibits CDK2 activity by competing with binding of activating cyclins.

HY-12149

A-867744	nAChR	Neurological Disease
A-867744 is a highly potent and selective type II positive allosteric modulator (PAM) of the alpha7 nicotinic acetylcholine receptors (nAChR) with an EC₅₀ of 1.0 μM .

HY-112089

Naporafenib 2 Publications Verification LXH254	Raf p38 MAPK Bcr-Abl	Cancer
Naporafenib (LXH254) is a potent, selective, orally active, type II BRAF and CRAF inhibitor, with IC₅₀ values of 0.072 and 0.21 nM against CRAF and BRAF, respectively .

HY-111507

PDGFRα kinase inhibitor 1	PDGFR	Cancer
PDGFRα kinase inhibitor 1 is a highly selective type II PDGFRα kinase inhibitor with IC₅₀s of 132 nM and 6115 nM for PDGFRα and PDGFRβ, respectively .

HY-145872

HBV-IN-20

HBV Infection

HBV-IN-20 is a potent and oral active HBV inhibitor with an EC₅₀ of 0.46 µM. HBV-IN-20 is a typical type II CpAM (core protein assembly modulators) .

HBV-IN-20	HBV	Infection
HBV-IN-20 is a potent and oral active HBV inhibitor with an EC₅₀ of 0.46 µM. HBV-IN-20 is a typical type II CpAM (core protein assembly modulators) .

HY-100875

Bisantrene 5 Publications Verification CL216942	Topoisomerase	Cancer
Bisantrene is a highly effective antitumor agent, it exerts its cytotoxicity by affecting DNA intercalation. Bisantrene targets eukaryotic type II topoisomerases. Bisantrene is a substrate of MDR1 .

HY-100875A

Bisantrene dihydrochloride 5 Publications Verification CL-216942 dihydrochloride	Topoisomerase	Cancer
Bisantrene dihydrochloride is a highly effective antitumor agent, it exerts its cytotoxicity by affecting DNA intercalation. Bisantrene dihydrochloride targets eukaryotic type II topoisomerases. Bisantrene dihydrochloride is a substrate of MDR1 .

HY-135130

Bischloroanthrabenzoxocinone (-)-BABX	Bacterial	Infection
Bischloroanthrabenzoxocinone is a potent Type II fatty acid synthesis (FASII) inhibitor. Bischloroanthrabenzoxocinone inhibits fatty acid synthesis. Bischloroanthrabenzoxocinone shows antibacterial activities and inhibits phospholipid, DNA, RNA, protein, and cell wall synthesis .

HY-110178

WWL123	MAGL	Inflammation/Immunology
WWL123, a carbamate-based compound, is a potent and selective ABHD6 inhibitor. WWL123 can be used for research of inflammation, metabolic disorders (obesity and type II diabetes mellitus) and epilepsy .

HY-N12191

Cangorinine E-1	HSV	Others
Cangorinine E-1 (compound 11) is a dihydroagarofuran derivative of the sesquiterpenoid family. Cangorinine E-1 exhibits weak inhibitory effects on herpes simplex virus type II (HSV) .

HY-162042

AMPK activator 14	AMPK	Metabolic Disease
AMPK activator 14 (compound 32) is an orally active AMPK activator. AMPK activator 14 decreases fasted glucose and insulin levels in a db/db mouse model of Type II diabetes .

Cat. No.	Product Name

HY-L018

TGF-beta/Smad Compound Library

226 compounds

The transforming growth factor beta (TGF-β) signaling pathway is involved in many cellular processes in both the adult organism and the developing embryo including cell growth, cell differentiation, apoptosis, cellular homeostasis and other cellular functions. The TGF-β superfamily comprises TGF-βs, bone morphogenetic proteins (BMPs), activins and related proteins. Signaling begins with the binding of a TGF beta superfamily ligand to a TGF beta type II receptor. The type II receptor is a serine/threonine receptor kinase, which catalyzes the phosphorylation of the Type I receptor. The type I receptor then phosphorylates receptor-regulated SMADs (R-SMADs) which can now bind the coSMAD (e.g. SMAD4). R-SMAD/coSMAD complexes accumulate in the nucleus where they act as transcription factors and participate in the regulation of target gene expression. Deregulation of TGF-β signaling contributes to developmental defects and human diseases, including cancers, some bone diseases, chronic kidney disease, etc.

MCE designs a unique collection of 226 TGF-beta/Smad signaling pathway compounds. TGF-beta/Smad Compound Library acts as a useful tool for TGF-beta/Smad-related drug screening and disease research.

HY-L040

Anti-diabetic Compound Library

748 compounds

Diabetes mellitus, usually called diabetes, is a group of metabolic disorders characterized by a high blood sugar level over a prolonged period of time. The most common types are Type I and Type II. Type I diabetes (T1D), also called juvenile onset diabetes mellitus or insulin-dependent diabetes mellitus, is characterized by destruction of the β-cells of the pancreas and insulin is not produced, whereas type II diabetes (T2D), also called non-insulin-dependent diabetes mellitus, is characterized by a progressive impairment of insulin secretion and relative decreased sensitivity of target tissues to the action of this hormone. Type 2 diabetes accounts for the vast majority of all diabetes mellitus. Diabetes of all types can lead to complications in many parts of the body and can increase the overall risk of dying prematurely. Possible complications include kidney failure, leg amputation, vision loss and nerve damage.

The pathogenesis of diabetes is complicated, and development of the safe and effective drugs against diabetes is full of challenge. Increasing studies have confirmed that the pathogenesis of diabetes is related to various signaling pathways, such as insulin signaling pathway, AMPK pathway, PPAR regulation and chromatin modification pathways. These signaling pathways have thus become the major source of the promising novel drug targets to treat metabolic diseases and diabetes.

MCE Anti-diabetic Compound Library owns a unique collection of 748 compounds, which mainly target SGLT, PPAR, DPP-4, AMPK, Dipeptidyl Peptidase, Glucagon Receptor, etc. This library is a useful tool for discovery anti-diabetes drugs.

Cat. No.	Product Name	Type

HY-NP003

*Bovine Type II* Collagen** Collagen, type II, Immunization Grade	Native Proteins
Type II collagen II is a protein used to treat osteoarthritis. Type II collagen shows significant efficacy in improving the pain and inflammation of collagen induced arthritis in mice .

HY-A0104I

*HPMC (Type II,Viscosity:100000mPa.s)* Hypromellose (type II,Viscosity:100000mPa.s); (Hydroxypropyl)methyl cellulose (type II,Viscosity:100000mPa.s); Celacol HPM 5000 (type II,Viscosity:100000mPa.s)	Biochemical Assay Reagents
Hydroxypropylmethylcellulose (Type II,Viscosity:100000mPa.s) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-A0104E

*HPMC (Type II,Viscosity:100mPa.s)* Hypromellose (type II,Viscosity:100mPa.s); (Hydroxypropyl)methyl cellulose (type II,Viscosity:100mPa.s); Celacol HPM 5000 (type II,Viscosity:100mPa.s)	Biochemical Assay Reagents
Hypromellose (Type II,Viscosity:100mPa.s) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-A0104H

*HPMC (Type II,Viscosity:15000mPa.s)* Hypromellose (type II,Viscosity:15000mPa.s); (Hydroxypropyl)methyl cellulose (type II,Viscosity:15000mPa.s); Celacol HPM 5000 (type II,Viscosity:15000mPa.s)	Biochemical Assay Reagents
Hypromellose (Type II,Viscosity:15000mPa.s) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-A0104F

*HPMC (Type II,Viscosity:400mPa.s)* Hypromellose (type II,Viscosity:400mPa.s); (Hydroxypropyl)methyl cellulose (type II,Viscosity:400mPa.s); Celacol HPM 5000 (type II,Viscosity:400mPa.s)	Biochemical Assay Reagents
Hypromellose (Type II,Viscosity:400mPa.s) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-A0104G

*HPMC (Type II,Viscosity:4000mPa.s)* Hypromellose (type II,Viscosity:4000mPa.s); (Hydroxypropyl)methyl cellulose (type II,Viscosity:4000mPa.s); Celacol HPM 5000 (type II,Viscosity:4000mPa.s)	Biochemical Assay Reagents
Hypromellose (Type II,Viscosity:4000mPa.s) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-125857

Cytochrome C	Biochemical Assay Reagents
Cytochrome C is a multi-functional enzyme involving in life and death decisions of the cell. Cytochrome C is essential in mitochondrial electron transport and intrinsic type II apoptosis .

HY-W250316

Alpha-d-Glucopyranoside, beta-d-fructofuranosyl, octadecanoate Sucrose Stearate, type II, USP	Biochemical Assay Reagents
Alpha-d-Glucopyranoside, beta-d-fructofuranosyl, octadecanoate is a carbohydrate.

HY-E70144

N-Acetylglucosaminyltransferase 1 EC:2.4.1.101; MGAT1	Enzyme Substrates
N-Acetylglucosaminyltransferase1 (EC:2.4.1.101, MGAT1) shows typical features of a type II transmembrane protein. N-Acetylglucosaminyltransferase1 is believed to be essential for normal embryogenesis .

HY-P2990

Enteropeptidase TMPRSS15	Biochemical Assay Reagents
Enteropeptidase (TMPRSS15), a type II transmembrane serine protease and a physiological activator of trypsinogen. Enteropeptidase is associated with the brush border membrane (BBM) of the enterocytes in the upper small intestine. Trypsinogen is the primary substrate for Enteropeptidase. Enteropeptidase is involved in digestion in humans and animals .

Cat. No.	Product Name	Target	Research Area

HY-P0220A

PACAP (6-38), human, ovine, rat TFA 1 Publications Verification	PACAP Receptor	Neurological Disease
PACAP (6-38), human, ovine, rat TFA is a potent PACAP receptor antagonist with IC₅₀s of 30, 600, and 40 nM for *PACAP type* I receptor, PACAP type II receptor VIP₁, and PACAP type II receptor VIP₂**, respectively.

HY-P0221

PACAP (1-38), human, ovine, rat 3 Publications Verification Pituitary Adenylate Cyclase Activating Polypeptide 38	PACAP Receptor	Neurological Disease
PACAP (1-38), human, ovine, rat is a neuropeptide with 38 amino acid residues. PACAP (1-38) binds to *PACAP type* I receptor, PACAP type II receptor VIP₁, and PACAP type II receptor VIP₂ with IC₅₀**s of 4 nM, 2 nM, and 1 nM, respectively.

HY-P5003

*Collagen Type II* Fragment**	Biochemical Assay Reagents	Inflammation/Immunology
Collagen Type II Fragment is an anti-inflammatory peptide that potently inhibits collagen-induced arthritis (CIA) in mice. Collagen Type II Fragment can be used for research on inflammation and immunity .

HY-P0220

PACAP (6-38), human, ovine, rat	PACAP Receptor	Neurological Disease
PACAP (6-38), human, ovine, rat is a potent PACAP receptor antagonist with IC₅₀s of 30, 600, and 40 nM for *PACAP type* I receptor, PACAP type II receptor VIP₁, and PACAP type II receptor VIP₂**, respectively.

HY-P0221A

PACAP (1-38), human, ovine, rat TFA Pituitary Adenylate Cyclase Activating Polypeptide 38 TFA	PACAP Receptor	Neurological Disease
PACAP (1-38), human, ovine, rat TFA is a neuropeptide with 38 amino acid residues. PACAP (1-38) binds to *PACAP type* I receptor, PACAP type II receptor VIP₁, and PACAP type II receptor VIP₂ with IC₅₀**s of 4 nM, 2 nM, and 1 nM, respectively.

HY-P3675

LH-RH (4-10)	GnRH Receptor	Endocrinology
LH-RH (4-10) is a heptapeptide, one of major degradation products of luteinising-hormone releasing hormone (LHRH) via pituitary and hypothalamus. LH-RH (4-10) produced in macrophages and type II pneumocytes .

HY-P3674

LH-RH (7-10)	GnRH Receptor	Endocrinology
LH-RH (7-10) is a tetrapeptide, one of major degradation products of luteinising-hormone releasing hormone (LHRH) via pituitary and hypothalamus. LH-RH (7-10) produced in macrophages, type I-like and type II pneumocytes .

HY-P2990

Enteropeptidase TMPRSS15	Ser/Thr Protease	Metabolic Disease
Enteropeptidase (TMPRSS15), a type II transmembrane serine protease and a physiological activator of trypsinogen. Enteropeptidase is associated with the brush border membrane (BBM) of the enterocytes in the upper small intestine. Trypsinogen is the primary substrate for Enteropeptidase. Enteropeptidase is involved in digestion in humans and animals .

HY-P4767

Amylin (1-13) (human)	Peptides	Metabolic Disease
Amylin (1-13) (human) is a fragment and a residues within amyloid cores of Amylin (human IAPP). Amylin is a glucose-regulating hormone, deposits as amyloid fibrils in condition of type II diabetes (T2D). Amylin (1-13) (human) has no effect on firbl formation, as it cannot form fibrils by itself .

HY-P2501

Amylin (8-37), human	Amylin Receptor	Metabolic Disease
Amylin (8-37), human is a fragment of human Amylin. Amylin (8-37), human has direct vasodilator effects in the isolated mesenteric resistance artery of the rat. Human Amylin is a small hormone secreted by pancreatic β-cells that forms aggregates under insulin deficiency metabolic conditions, and it constitutes a pathological hallmark of type II diabetes mellitus .

HY-P5839

α-Conotoxin MrIC	nAChR	Neurological Disease
α-Conotoxin MrIC is an α7nAChR biased agonist. α-Conotoxin MrIC exclusively activates α7nAChR regulated by type II positive allosteric modulators, including PNU120596. α-Conotoxin MrIC can be used to study neurological diseases and also to probe the pharmacological properties of α7nAChR .

HY-P3600

FIZZ-1 (32-51) (mouse)	Apoptosis	Inflammation/Immunology
FIZZ-1 (32-51) (mouse) is a cysteine-rich secretory protein that is highly expressed by macrophages, bronchial epithelial and type II alveolar epithelial cells (AEC) in allergic airway inflammation. FIZZ1 (32-51) (mouse) also shows an antiapoptotic effect on lung fibroblasts. FIZZ-1 (32-51) (mouse) can be used in the study of allergic pneumonia .

HY-P1110

AF12198 1 Publications Verification	Interleukin Related	Inflammation/Immunology
AF12198 is a potent, selective and specific peptide antagonist for human type I interleukin-1 receptor (IL1-R1) (IC₅₀=8 nM) but not the human type II receptor (IC₅₀=6.7 µM) or the murine type I receptor (IC₅₀>200 µM). AF12198 inhibits IL-1-induced IL-8 production (IC₅₀=25 nM) and IL-1-induced intercellular adhesion molecule-1 (ICAM-1) expression (IC₅₀=9 nM) in vitro. AF12198 has anti-inflammatory activities and blocks responses to IL-1 in vivo .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-109500

Masoprocol meso-Nordihydroguaiaretic acid; meso-NDGA	other families Classification of Application Fields Source classification Phenols Polyphenols Metabolic Disease Plants Disease Research Fields	Lipoxygenase
Masoprocol (meso-Nordihydroguaiaretic acid) is a potent and orally active lipoxygenase inhibitor. Masoprocol shows antihyperglycemic activity. Masoprocol decreases the glucose concentration and hepatic triglyceride in vivo. Masoprocol has the potential for the research of type II diabetes .

HY-W011303

Phytosphingosine 1 Publications Verification 4-Hydroxysphinganine	Infection Structural Classification Natural Products Human Gut Microbiota Metabolites Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Cancer	Apoptosis Endogenous Metabolite Fungal Free Fatty Acid Receptor
Phytosphingosine is a phospholipid with anti-inflammatory, antibacterial, and anti-cancer activities, which can induce apoptosis. Phytosphingosine is an immune regulator and can be used in the study of inflammatory skin diseases. Phytosphingosine is also an activator of GPR120 with an IC₅₀ value of 33.4 μM and can be used in the study of type II diabetes .

HY-N3269

Methyl p-hydroxyphenyllactate	Monophenols Classification of Application Fields Labiatae Source classification Other Diseases Phenols Peucephyllum schottii A.Gray Plants Disease Research Fields	Others
Methyl p-hydroxyphenyllactate (MeHPLA) is an important cell growth-regulating agent which binds to nuclear type II binding sites in normal and malignant cells .

HY-N12191

Cangorinine E-1	Structural Classification Alkaloids Terpenoids Other Alkaloids Sesquiterpenes Source classification Celastraceae Plants Tripterygium wilfordii Hook. f.	HSV
Cangorinine E-1 (compound 11) is a dihydroagarofuran derivative of the sesquiterpenoid family. Cangorinine E-1 exhibits weak inhibitory effects on herpes simplex virus type II (HSV) .

HY-N2589

Isosaponarin	Flavonoids Vaccaria segetalis (Neck.) Garcke Classification of Application Fields Flavones Source classification Other Diseases Phenols Polyphenols Plants Disease Research Fields Caryophyllaceae	TGF-β Receptor
Isosaponarin is a flavone glycoside isolated from wasabi leaves. Isosaponarin increases collagen synthesis, caused by up-regulated *TGF-β type II* receptor (TβR-II) and prolyl 4-hydroxylase (P4H)** proteins production .

HY-42680

D-Tagatose D-(-)-Tagatose	Structural Classification Microorganisms Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Sweeteners Saccharides Monosaccharides Food Research	Endogenous Metabolite
D-Tagatose (D-(-)-Tagatose) is a rare monosaccharide found in nature with prebiotic characteristics. D-Tagatose is as a substitute for sucrose and a low-calorie sweetener in foodstuffs such as gum, fruit juice, and beverages. D-Tagatose is also a potential antidiabetic agent for the research of type II diabetes and a prebiotic to help elevate beneficial bacteria in the colon, prevent colon cancer, and lower cholesterol .

HY-W011303A

(Rac)-Phytosphingosine (Rac)-4-Hydroxysphinganine	Structural Classification Natural Products other families Source classification Plants	Others
(Rac)-Phytosphingosine ((Rac)-4-Hydroxysphinganine) is the racemate of Phytosphingosine (HY-W011303). Phytosphingosine is a phospholipid with anti-inflammatory, antibacterial, and anti-cancer activities, which can induce apoptosis. Phytosphingosine is an immune regulator and can be used in the study of inflammatory skin diseases. Phytosphingosine is also an activator of GPR120 with an IC₅₀ value of 33.4 μM and can be used in the study of type II diabetes .

Species:	Human (25) Virus (1) Rhesus Macaque (5) Mouse (7) Rat (1) Cynomolgus (2)
Tag:	His (23) SUMO (1) Tag Free (6) Avi (2) Myc (1) GST (4) Fc (12)
Source:	HEK293 (24) E. coli Cell-free (1) CHO (1) Sf9 insect cells (2) Sf9 insect cells (7) E. coli (9)

Cat. No.	Compare	Product Name	Species	Source

HY-P72052

	KRT8 Protein, Human (Baculovirus, His-Myc) CARD2; CK 8; CK-8; CK8; CYK8; CYKER; Cytokeratin endo A; Cytokeratin-8; DreK8; EndoA; K2C8; K2C8_HUMAN; K8; Keratin 8; Keratin type II cytoskeletal 8 ; Keratin; type II cytoskeletal 8; Keratin-8; KO; Krt 2.8; KRT8; MGC118110; MGC174782; MGC53564; MGC85764; sb:cb186; type-II keratin Kb8	Human	Sf9 insect cells
	The KRT8 protein, in cooperation with KRT19, critically links the contractile apparatus of the striated rib muscle to dystrophin. This heterotetramer consists of two type I keratins and two type II keratins, forming a heterodimer with KRT18. KRT8 Protein, Human (Baculovirus, His-Myc) is the recombinant human-derived KRT8 protein, expressed by Sf9 insect cells , with N-10*His, C-Myc labeled tag. The total length of KRT8 Protein, Human (Baculovirus, His-Myc) is 483 a.a., with molecular weight of ~57.6 kDa.

HY-P702298

	GNRHR2 Protein, Rhesus Macaque (Cell-Free, His) Gonadotropin-releasing hormone II receptor; type II GnRH receptor	Rhesus Macaque	E. coli Cell-free
	The GNRHR2 Protein serves as a receptor for gonadotropin-releasing hormone II (GnRH II), initiating its action through association with G proteins that activate a phosphatidylinositol-calcium second messenger system. GNRHR2 Protein, Rhesus Macaque (Cell-Free, His) is the recombinant Rhesus Macaque-derived GNRHR2 protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of GNRHR2 Protein, Rhesus Macaque (Cell-Free, His) is 379 a.a., with molecular weight of 44.3 kDa.

HY-P72090

	Arginase-2/ARG2 Protein, Mouse (His-SUMO) Arg2Arginase-2; mitochondrial; EC 3.5.3.1; Arginase II; Kidney-type arginase; Non-hepatic arginase; type II arginase	Mouse	E. coli
	Arginase-2 (ARG2) is a multifunctional regulator central to the regulation of arginine metabolism and nitric oxide synthesis outside the urea cycle. In addition to its hepatic effects, ARG2 affects innate and adaptive immune responses, negatively affecting the survival of activated CD4(+) and CD8(+) T cells. Arginase-2/ARG2 Protein, Mouse (His-SUMO) is the recombinant mouse-derived Arginase-2/ARG2 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag. The total length of Arginase-2/ARG2 Protein, Mouse (His-SUMO) is 332 a.a., with molecular weight of ~52.4 kDa.

HY-P702180

NADH dehydrogenase Protein type II, Gluconobacter oxydans

GOX1675; NADH dehydrogenase type II
Others E. coli
HY-P702181

NADH dehydrogenase Protein type II, Gluconobacter oxydans (His)

GOX1675; NADH dehydrogenase type II
Others E. coli

HY-P70228

	*Kanamycin kinase type II/NEO protein, Klebsiella pneumoniae* rKlAminoglycoside 3'-phosphotransferase; Aminoglycoside 3'-phosphotransferase; APH(3')-II; APH(3')II; Kanamycin kinase type II; Neomycin-kanamycin phosphotransferase type II; neo	Others	E. coli
	The Kanamycin kinase type II/NEO protein imparts resistance to aminoglycoside antibiotics, including kanamycin, neomycin, paromomycin, ribostamycin, butirosin, and gentamicin B. It counteracts their inhibitory effects, showcasing the protein's versatility in mitigating the impact of various antibiotics and enabling the organism to thrive in their presence. Kanamycin kinase type II/NEO protein, Klebsiella pneumoniae is the recombinant Kanamycin kinase type II/NEO protein, expressed by E. coli , with tag free. The total length of Kanamycin kinase type II/NEO protein, Klebsiella pneumoniae is 264 a.a., with molecular weight of 26-30 kDa.

HY-P70228A

	*Kanamycin kinase type II/NEO protein, Klebsiella pneumoniae (Tag Free)* rKlAminoglycoside 3'-phosphotransferase; Aminoglycoside 3'-phosphotransferase; APH(3')-II; APH(3')II; Kanamycin kinase type II; Neomycin-kanamycin phosphotransferase type II; neo	Others	E. coli
	The Kanamycin kinase type II/NEO protein imparts resistance to aminoglycoside antibiotics, including kanamycin, neomycin, paromomycin, ribostamycin, butirosin, and gentamicin B. It counteracts their inhibitory effects, showcasing the protein's versatility in mitigating the impact of various antibiotics and enabling the organism to thrive in their presence. Kanamycin kinase type II/NEO protein, Klebsiella pneumoniae (Tag Free) is the recombinant Kanamycin kinase type II/NEO protein, expressed by E. coli , with tag free. The total length of Kanamycin kinase type II/NEO protein, Klebsiella pneumoniae (Tag Free) is 264 a.a., with molecular weight of approximately 29.68 kDa.

HY-P79250

MCV-type II Chemokine-like Protein, Virus

C-C chemokine-like protein; MC148R; MC148; Molluscum Contagiosum Virus type II
Virus E. coli

HY-P700953

	AMHR2/MISRII Protein, Human (HEK293) MIS type II receptor; MISRII; MRII; AMHR; MISR2; AMHR2; AMH type II receptor; AMHR2; AMHRII; C14	Human	HEK293
	AMHR2/MISRII Protein, upon ligand binding, forms a receptor complex with two type II and two type I kinases. Type II receptors activate type I receptors through phosphorylation, leading to autophosphorylation. Activated type I receptors engage SMAD transcriptional regulators, initiating downstream signaling pathways. Crucially, AMHR2/MISRII acts as a receptor for anti-Muellerian hormone, mediating cellular responses triggered by the hormone. AMHR2/MISRII Protein, Human (HEK293) is the recombinant human-derived AMHR2/MISRII protein, expressed by HEK293 , with tag free. The total length of AMHR2/MISRII Protein, Human (HEK293) is 127 a.a., with molecular weight of 30-40 kDa.

HY-P77870

	AMHR2/MISRII Protein, Human (HEK293, Fc) MIS type II receptor; MISRII; MRII; AMHR; MISR2; AMHR2; AMH type II receptor; AMHR2; AMHRII; C14	Human	HEK293
	AMHR2/MISRII Protein, upon ligand binding, forms a receptor complex with two type II and two type I kinases. Type II receptors activate type I receptors through phosphorylation, leading to autophosphorylation. Activated type I receptors engage SMAD transcriptional regulators, initiating downstream signaling pathways. Crucially, AMHR2/MISRII acts as a receptor for anti-Muellerian hormone, mediating cellular responses triggered by the hormone. AMHR2/MISRII Protein, Human (HEK293, Fc) is the recombinant human-derived AMHR2/MISRII protein, expressed by HEK293 , with C-hFc labeled tag. The total length of AMHR2/MISRII Protein, Human (HEK293, Fc) is 127 a.a., with molecular weight of 50-65 kDa.

HY-P77560

	AMHR2/MISRII Protein, Cynomolgus/Rhesus Macaque (HEK293, Fc) MIS type II receptor; MISRII; MRII; AMHR; MISR2; AMHR2; AMH type II receptor; AMHR2; AMHRII; C14	Rhesus Macaque;Cynomolgus	HEK293
	AMHR2/MISRII Protein is expressed in a large number of female reproductive organs. AMHR2 Protein, upon ligand binding, assembles a receptor complex with two type II and two type I transmembrane serine/threonine kinases. Type II receptors initiate the signaling cascade by phosphorylating and activating type I receptors, which undergo autophosphorylation. Activated type I receptors then engage and activate SMAD transcriptional regulators, modulating downstream gene expression. Furthermore, AMHR2 serves as the receptor for anti-Muellerian hormone. AMHR2/MISRII Protein, Cynomolgus/Rhesus Macaque (HEK293, Fc) is the recombinant cynomolgus, Rhesus Macaque-derived AMHR2/MISRII protein, expressed by HEK293 , with C-hFc labeled tag. The total length of AMHR2/MISRII Protein, Cynomolgus/Rhesus Macaque (HEK293, Fc) is 127 a.a., with molecular weight of 55-60 kDa.

HY-P702773

RNASEH1 Protein, Human (His)

Ribonuclease H type II; Ribonuclease H1; RNH1; RNase H1
Human E. coli

HY-P701750

	PIP4K2C Protein, Human PIP4K2C; Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma; Phosphatidylinositol 5-phosphate 4-kinase type II gamma; PI(5)P 4-kinase type II gamma; PIP4KII-gamma	Human	E. coli
	PIP4K2C protein is a low-activity phosphatidylinositol 5-phosphate 4-kinase that functions as a GTP sensor, and its GTP-dependent kinase activity is higher than ATP-dependent activity. In addition to its catalytic role, PIP4K2C independently negatively regulates insulin signaling by interacting with PIP5K and inhibits PIP5K-mediated PtdIns(4,5)P2 synthesis. PIP4K2C Protein, Human is the recombinant human-derived PIP4K2C protein, expressed by E. coli , with tag free. The total length of PIP4K2C Protein, Human is 420 a.a., .

HY-P78693

	AMHR2/MISRII Protein, Mouse (HEK293, His) MIS RII; MRII; AMHR2; AMHR; MISR2; AMH type II receptor	Mouse	HEK293
	AMHR2/MISRII Protein, upon ligand binding, assembles a receptor complex with two type II and two type I transmembrane serine/threonine kinases. Type II receptors initiate the signaling cascade by phosphorylating and activating type I receptors, which undergo autophosphorylation. Activated type I receptors then engage and activate SMAD transcriptional regulators, modulating downstream gene expression. Notably, AMHR2/MISRII serves as the receptor for anti-Muellerian hormone, playing a pivotal role in mediating cellular responses to this hormone. AMHR2/MISRII Protein, Mouse (HEK293, His) is the recombinant mouse-derived AMHR2/MISRII protein, expressed by HEK293, with C-His labeled tag. The total length of AMHR2/MISRII Protein, Mouse (HEK293, His) is 132 a.a., with molecular weight of approximately 25 kDa & 30 kDa, respectively.

HY-P76761

	CaMKII alpha/CAMK2A Protein, Human (sf9, GST) Calcium/calmodulin-dependent protein kinase type II subunit alpha; CAMKA	Human	Sf9 insect cells
	CaMKII α/CAMK2A protein functions autonomously upon Ca(2+)/calmodulin binding and autophosphorylation. CaMKII alpha/CAMK2A Protein, Human (sf9, GST) is the recombinant human-derived CaMKII alpha/CAMK2A protein, expressed by Sf9 insect cells , with N-GST labeled tag. The total length of CaMKII alpha/CAMK2A Protein, Human (sf9, GST) is 478 a.a., with molecular weight of ~80 kDa.

HY-P7669

	BMPR-II Protein, Human (HEK293, His) rHuBMPR-II, His; BMP type-2 Receptor; BMP type II Receptor; BMPR-II; BMPR2	Human	HEK293
	BMP Type II Receptor (BMPR2) is a type II member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. BMPR2 is highly expressed in the heart and liver, and involves in osteogenesis and cell differentiation, essential for embryogenesis, development, and adult tissue homeostasis. BMPR2 is associated with tubulin stability, the inhibition of BMPR2 destabilizes the microtubules promoting cell death of cancer cells that involves the activation of the lysosomes. Human BMPR2 protein contains 1038 amino acids and a transmembrane domain (151-171 a.a.). BMPR-II Protein, Human (HEK293, His) is the extracellular part of the complete BMPR2 protein, produced by HEK293 cells (S27-I151) with C-terminal 6*His-tag.

HY-P700597

	PIP4K2B Protein, Human (His) PIP4K2B; phosphatidylinositol-5-phosphate 4-kinase, type II, beta; phosphatidylinositol 4 phosphate 5 kinase, type II, beta , PIP5K2B; phosphatidylinositol-5-phosphate 4-kinase type-2 beta; PIP5KIIB; PIP5KIIbeta; PIP4KII-beta; PTDINS(4)P-5-kinase; PI(5)P 4-kinase type II beta; diphosphoinositide kinase 2-beta; ptdIns(5)P-4-kinase isoform 2-beta; 1-phosphatidylinositol-4-phosphate kinase; 1-phosphatidylinositol-5-phosphate 4-kinase 2-beta; phosphatidylinositol-4-phosphate 5-kinase, type II, beta; PI5P4KB; PIP5K2B	Human	E. coli
	PIP4K2B Protein actively synthesizes phosphatidylinositol 4,5-bisphosphate, preferring GTP over ATP in PI(5)P phosphorylation, with enzymatic activity linked to physiological GTP levels. Its unique GTP-sensing ability critically aids metabolic adaptation. PIP4K2B, part of PIP4Ks, negatively influences insulin signaling via a catalytic-independent mechanism, interacting with PIP5Ks to suppress PIP5K-mediated PtdIns(4,5)P2 synthesis, hindering insulin-dependent conversion to PtdIns(3,4,5)P3. This multifaceted role emphasizes PIP4K2B's significance in modulating key signaling pathways for cellular homeostasis and metabolic responsiveness. PIP4K2B Protein, Human (His) is the recombinant human-derived PIP4K2B protein, expressed by E. coli, with N-10*His labeled tag. The total length of PIP4K2B Protein, Human (His) is 415 a.a., with molecular weight of 53.3 kDa.

HY-P74690

	NKG2A Protein, Mouse (HEK293, His) NKG2-A/NKG2-B type II integral membrane protein; CD159a; KLRC1	Mouse	HEK293
	NKG2A Protein, a crucial immune inhibitory receptor, forms a complex with KLRD1 on lymphocyte subsets for self-nonself discrimination. Recognizing HLA-E loaded with self-peptides, it monitors MHC class I expression in healthy cells, promoting self-tolerance. NKG2A transmits signals through ITIMs, recruiting tyrosine phosphatases to counteractivate receptors. As a key inhibitor on NK cells, it regulates their functions, distinguishing harmless from pathogenic antigens. In the tumor microenvironment, NKG2A acts as an immune inhibitory checkpoint, contributing to cell exhaustion. During viral infection, it inhibits NK cell cytotoxicity, facilitating viral immune escape. NKG2A Protein, Mouse (HEK293, His) is the recombinant mouse-derived NKG2A protein, expressed by HEK293 , with N-His labeled tag. The total length of NKG2A Protein, Mouse (HEK293, His) is 151 a.a., with molecular weight of 33-40 kDa.

HY-P72503

	NKG2D/CD314 Protein, Mouse (HEK293, His) NKG2-D type II integral membrane protein; CD314; KLRK1; NKG2-D	Mouse	HEK293
	The NKG2D/CD314 protein activates and stimulates the innate immune response of NK cells by binding to stress-inducing ligands on tumor and virus-infected cells. It also acts as a costimulatory receptor for TCR, enhancing T cell activation and eliminating tumor cells. NKG2D/CD314 Protein, Mouse (HEK293, His) is the recombinant mouse-derived NKG2D/CD314 protein, expressed by HEK293 , with N-6*His labeled tag. The total length of NKG2D/CD314 Protein, Mouse (HEK293, His) is 139 a.a., with molecular weight of 20-30 kDa.

HY-P72504

	NKG2D/CD314 Protein, Cynomolgus (HEK293, His) NKG2-D type II integral membrane protein; CD314; KLRK1; NKG2-D	Cynomolgus	HEK293
	The NKG2D/CD314 protein serves as an important activating and costimulatory receptor in immune surveillance. It binds to stress-inducing ligands on tumor and virus-infected cells, activates NK cells and serves as a costimulatory receptor for CD8(+) T cell-mediated adaptive responses, thereby enhancing T cell activation. NKG2D/CD314 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived NKG2D/CD314 protein, expressed by HEK293 , with N-6*His labeled tag. The total length of NKG2D/CD314 Protein, Cynomolgus (HEK293, His) is 139 a.a., with molecular weight of 22-35 kDa.

HY-P73319

	NKG2D/CD314 Protein, Human (sf9, His) CD314; KLRK1; NKG2-D type II integral membrane protein; NKG2D	Human	Sf9 insect cells
	The NKG2D/CD314 protein serves as a key activating and costimulatory receptor in immune surveillance, binding to multiple stress-inducing ligands on tumor and virus-infected cells. It plays a dual role by stimulating NK cells and enhancing T cell activation in CD8(+) T cell-mediated adaptive responses. NKG2D/CD314 Protein, Human (sf9, His) is the recombinant human-derived NKG2D/CD314 protein, expressed by Sf9 insect cells , with N-His labeled tag. The total length of NKG2D/CD314 Protein, Human (sf9, His) is 139 a.a., with molecular weight of ~22.6 kDa.

HY-P74691

	NKG2A Protein, Human (Biotinylated, HEK293, His) NKG2-A/NKG2-B type II integral membrane protein; CD159a; KLRC1	Human	HEK293
	The NKG2A protein is an important immunosuppressive receptor that forms a complex with KLRD1 on lymphocyte subsets for self-non-self discrimination. It recognizes HLA-E loaded with self-peptides, monitors MHC class I expression in healthy cells, and promotes self-tolerance. NKG2A Protein, Human (Biotinylated, HEK293, His) is the recombinant human-derived NKG2A protein, expressed by HEK293 , with N-His labeled tag. The total length of NKG2A Protein, Human (Biotinylated, HEK293, His) is 140 a.a., with molecular weight of ~18.4 kDa.

HY-P75940

	NKG2D/CD314 Protein, Rhesus Macaque (sf9, His) NKG2-D type II integral membrane protein; NK cell receptor D; KLRK1	Rhesus Macaque	Sf9 insect cells
	The NKG2D/CD314 protein serves as a key activating and costimulatory receptor in immune surveillance. It binds to stress-inducing ligands on tumor and virus-infected cells and triggers the innate immune response of NK cells. NKG2D/CD314 Protein, Rhesus Macaque (sf9, His) is the recombinant Rhesus Macaque-derived NKG2D/CD314 protein, expressed by Sf9 insect cells , with N-His labeled tag. The total length of NKG2D/CD314 Protein, Rhesus Macaque (sf9, His) is 139 a.a., with molecular weight of ~18.3 kDa.

HY-P7426

	TGFBR2/TGF-beta RII Protein, Human (HEK293, Fc) TGFR-2; TGF-beta type II receptor; TGF-beta receptor type 2; TbetaR-II	Human	HEK293
	TGF-beta receptor 2 Protein, Human (HEK293, Fc), a fragment of transforming growth factor-beta receptor type 2 (TβRII), consists of amino acid of Thr23-Asp159 with an Fc tag at the C-terminus.

HY-P7427

	TGFBR2/TGF-beta RII Protein, Mouse (HEK293, Fc) TGFR-2; TGF-beta type II receptor; TGF-beta receptor type 2; TbetaR-II	Mouse	HEK293
	TGFBR2/TGF-beta RII Protein, Mouse (HEK293, Fc), a fragment of transforming growth factor-beta receptor type 2 (TβRII), consists of amino acid of Ile24-Asp159 with a 6His tag at the C-terminus.

HY-P7428

	TGFBR2/TGF-beta RII Protein, Mouse (HEK293, His) TGFR-2; TGF-beta type II receptor; TGF-beta receptor type 2; TbetaR-II	Mouse	HEK293
	TGFBR2/TGF-beta RII Protein, Mouse (HEK293, His), His consists of N-terminal ectodomain and C-terminal protein kinase domain with his tag. TGF-beta receptor type-2 is the ligand-binding receptor for all members of the TGF-β family.

HY-P73428

	TGFBR2/TGF-beta RII Protein, Human (sf9, His) TGFR-2; TGF-beta type II receptor; TGF-beta receptor type 2; TbetaR-II	Human	Sf9 insect cells
	The TGFBR2/TGF-β RII protein cooperates with TGFBR1 to form dedicated receptors for TGFB1, TGFB2, and TGFB3. It serves as a signal transducer that coordinates diverse physiological and pathological processes, including cell cycle regulation, mesenchymal cell dynamics, wound healing, matrix production, immunosuppression, and carcinogenesis. TGFBR2/TGF-beta RII Protein, Human (sf9, His) is the recombinant human-derived TGFBR2/TGF-beta RII protein, expressed by Sf9 insect cells , with C-His labeled tag. The total length of TGFBR2/TGF-beta RII Protein, Human (sf9, His) is 144 a.a., with molecular weight of ~24 kDa.

HY-P73430

	TGFBR2/TGF-beta RII Protein, Rat (HEK293, Fc) TGFR-2; TGF-beta type II receptor; TGF-beta receptor type 2; TbetaR-II	Rat	HEK293
	TGFBR2 is a transmembrane kinase that forms the TGF-β receptor complex with TGFBR1 and regulates various processes. Upon binding to cytokines, this complex activates TGFBR2, initiating SMAD-dependent signaling through phosphorylation of TGFBR1, SMAD2, and SMAD4. TGFBR2/TGF-beta RII Protein, Rat (HEK293, Fc) is the recombinant rat-derived TGFBR2/TGF-beta RII protein, expressed by HEK293 , with C-hFc labeled tag. The total length of TGFBR2/TGF-beta RII Protein, Rat (HEK293, Fc) is 166 a.a., with molecular weight of ~54 kDa.

HY-P76762

	CaMKII beta/CAMK2B Protein, Human (sf9, His-GST) Calcium/calmodulin-dependent protein kinase type II subunit beta; CAM2; CAMK2; CAMKB	Human	Sf9 insect cells
	CaMKII beta/CAMK2B, a calcium/calmodulin-dependent protein kinase, autonomously functions after Ca(2+)/calmodulin-binding and autophosphorylation. It plays vital roles in dendritic spine and synapse formation, neuronal plasticity, and the regulation of sarcoplasmic reticulum Ca(2+) transport in skeletal muscle. In neurons, it contributes to actin cytoskeleton reorganization, dendritic arborization, and migration of developing neurons. Additionally, it modulates skeletal muscle function in response to exercise and participates in the JAK-STAT signaling pathway by phosphorylating STAT1. Moreover, it phosphorylates RETREG1, enhancing its reticulophagy activity under endoplasmic reticulum stress conditions. CaMKII beta/CAMK2B Protein, Human (sf9, His-GST) is the recombinant human-derived CaMKII beta/CAMK2B protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag. The total length of CaMKII beta/CAMK2B Protein, Human (sf9, His-GST) is 503 a.a., with molecular weight of ~85 kDa.

HY-P77105

	NKG2A Protein, Cynomolgus/Rhesus Macaque (HEK293, Fc) NKG2-A/NKG2-B type II integral membrane protein; CD159a; KLRC1	Rhesus Macaque	HEK293
	The NKG2A protein is an important immunosuppressive receptor that forms a complex with KLRD1 on lymphocyte subsets for self-non-self discrimination. It recognizes HLA-E loaded with self-peptides, monitors MHC class I expression in healthy cells, and promotes self-tolerance. NKG2A Protein, Cynomolgus/Rhesus Macaque (HEK293, Fc) is the recombinant Rhesus Macaque-derived NKG2A protein, expressed by HEK293 , with N-hFc labeled tag. The total length of NKG2A Protein, Cynomolgus/Rhesus Macaque (HEK293, Fc) is 140 a.a., with molecular weight of 50-55 kDa.

HY-P78182

	NKG2A Protein, Human (Biotinylated, HEK293, His-Avi) NKG2-A/NKG2-B type II integral membrane protein; CD159a; KLRC1	Human	HEK293
	The NKG2A protein is an important immunosuppressive receptor that forms a complex with KLRD1 on lymphocyte subsets for self-non-self discrimination. It recognizes HLA-E loaded with self-peptides, monitors MHC class I expression in healthy cells, and promotes self-tolerance. NKG2A Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived NKG2A protein, expressed by HEK293 , with N-His, N-Avi labeled tag. The total length of NKG2A Protein, Human (Biotinylated, HEK293, His-Avi) is 134 a.a., with molecular weight of 32-48 kDa.

HY-P77229

	TGFBR2/TGF-beta RII Protein, Rhesus Macaque (HEK293, Fc) TGFR-2; TGF-beta type II receptor; TGF-beta receptor type 2; TbetaR-II	Rhesus Macaque	HEK293
	TGFBR2/TGF-beta RII Protein collaborates with TGFBR1 to form a dedicated receptor for TGFB1, TGFB2, and TGFB3. It serves as a signal transducer, orchestrating diverse physiological and pathological processes, including cell cycle regulation, mesenchymal cell dynamics, wound healing, matrix production, immunosuppression, and carcinogenesis. Upon cytokine binding, the receptor complex activates TGFBR1 through TGFBR2 phosphorylation, initiating the canonical SMAD-dependent TGF-beta signaling cascade. Additionally, TGFBR2 participates in non-canonical, SMAD-independent pathways. TGFBR2/TGF-beta RII Protein, Rhesus Macaque (HEK293, Fc) is the recombinant Rhesus Macaque-derived TGFBR2/TGF-beta RII protein, expressed by HEK293 , with C-hFc labeled tag. The total length of TGFBR2/TGF-beta RII Protein, Rhesus Macaque (HEK293, Fc) is 136 a.a., with molecular weight of ~50-70 KDa.

HY-P702655

CaMKII beta/CAMK2B Protein, Human (Q13554-1, sf9, GST)

Calcium/calmodulin-dependent protein kinase type II subunit beta; CAM2; CAMK2; CAMKB
Human Sf9 insect cells

HY-P701720

	CAMK2D Protein, Human (Sf9, GST) CAMK2D; Calcium/calmodulin-dependent protein kinase type II subunit delta; CaM kinase II subunit delta; CaMK-II subunit delta	Human	Sf9 insect cells
	CAMK2D protein regulates calcium levels and excitation-contraction coupling in the heart. CAMK2D Protein, Human (Sf9, GST) is the recombinant human-derived CAMK2D protein, expressed by Sf9 insect cells , with N-GST labeled tag. The total length of CAMK2D Protein, Human (Sf9, GST) is 498 a.a., .

HY-P76512

	NKG2D/CD314 Protein, Human (CHO, Fc) NKG2-D type II integral membrane protein; NK cell receptor D; CD314; KLRK1; D12S2489E	Human	CHO
	The NKG2D/CD314 protein serves as a key activating and costimulatory receptor in immune surveillance, binding to multiple stress-inducing ligands on tumor and virus-infected cells. It plays a dual role by stimulating NK cells and enhancing T cell activation in CD8(+) T cell-mediated adaptive responses. NKG2D/CD314 Protein, Human (CHO, Fc) is the recombinant human-derived NKG2D/CD314 protein, expressed by CHO , with N-hFc labeled tag. The total length of NKG2D/CD314 Protein, Human (CHO, Fc) is 139 a.a., with molecular weight of 50-64 & 37 KDa, respectively.

HY-P76513

NKG2D/CD314 Protein, Mouse (sf9, Fc)

NKG2-D type II integral membrane protein; NK cell receptor D; CD314; KLRK1; D12S2489E
Mouse Sf9 insect cells

HY-P72025

	TNFRII Protein, Human (HEK293, hFc) Tumor necrosis factor receptor 2; TNF-R2; Tumor necrosis factor receptor type II; TNF-RII; TNFR-II; p75; p80 TNF-alpha receptor; CD120b; Etanercept; TBP-2; TBPII	Human	HEK293
	TNFRII (TNFRSF1B) protein has a high ability to bind with tumor necrosis factor-alpha (TNF-α). TNFRII has pro-apoptotic function. TNFRII recruits TRAF2, induces gene expression and intensively crosstalks with TNF-R1. TNFRII selectively enhances the induction of apoptosis by the death receptor TNFRI. TNFRII Protein, Human (HEK293, hFc) is expressed by HEK293 and has a transmembrane region (L23-D257) with hFc tag at the C-terminus.

HY-P70551

	NKG2A Protein, Human (HEK293, His) NKG2-A/NKG2-B type II integral membrane protein; CD159 antigen-like family member A; NK cell receptor A; NKG2-A/B-activating NK receptor; CD159a; KLRC1; NKG2A	Human	HEK293
	The NKG2A protein is an important immunosuppressive receptor that forms a complex with KLRD1 on lymphocyte subsets for self-non-self discrimination. It recognizes HLA-E loaded with self-peptides, monitors MHC class I expression in healthy cells, and promotes self-tolerance. NKG2A Protein, Human (HEK293, His) is the recombinant human-derived NKG2A protein, expressed by HEK293 , with N-8*His labeled tag. The total length of NKG2A Protein, Human (HEK293, His) is 134 a.a., with molecular weight of 25-40 kDa.

HY-P72018

	NKG2D/CD314 Protein, Human (HEK293, Fc) CD314; CD314 antigen ; D12S2489E; Killer cell lectin like receptor subfamily K member 1; Killer cell lectin-like receptor subfamily K member 1; KLR; KLRC4 KLRK1 readthrough; KLRK1; NK cell receptor D; NK lectin-like receptor; NKG2 D activating NK receptor; NKG2 D type II integral membrane protein; NKG2-D; NKG2-D type II integral membrane protein; NKG2-D-activating NK receptor; Nkg2d; NKG2D_HUMAN; NKLLR; NKR P2; Nkrp2	Human	HEK293
	The NKG2D/CD314 protein serves as a key activating and costimulatory receptor in immune surveillance, binding to multiple stress-inducing ligands on tumor and virus-infected cells. It plays a dual role by stimulating NK cells and enhancing T cell activation in CD8(+) T cell-mediated adaptive responses. NKG2D/CD314 Protein, Human (HEK293, Fc) is the recombinant human-derived NKG2D/CD314 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of NKG2D/CD314 Protein, Human (HEK293, Fc) is 139 a.a., with molecular weight of ~43.6 kDa.

HY-P71126

	TNFRII Protein, Human (174a.a, HEK293, His) Tumor necrosis factor receptor superfamily member 1B; Tumor necrosis factor receptor 2; TNF-R2; Tumor necrosis factor receptor type II; TNF-RII; TNFR-II; p75; p80 TNF-alpha receptor; TNFRII; TNF RII	Human	HEK293
	TNFRII (TNFRSF1B) protein has a high ability to bind with tumor necrosis factor-alpha (TNF-α). TNFRII has pro-apoptotic function. TNFRII recruits TRAF2, induces gene expression and intensively crosstalks with TNF-R1. TNFRII selectively enhances the induction of apoptosis by the death receptor TNFRI. TNFRII Protein, Human (174a.a, HEK293, His) is expressed by HEK293 and has a transmembrane region (K288-S461) with 6*His tag at the C-terminus.

HY-P71206

	PIP4K2A Protein, Human (HEK293, His) 1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha; Diphosphoinositide kinase 2-alpha; PIP5KIII; Phosphatidylinositol 5-phosphate 4-kinase type II alpha; PtdIns(4)P-5-kinase B isoform; PtdIns(4)P-5-kinase C isoform; PtdIns(5)P-4-kinase isoform 2-alpha	Human	HEK293
	The PIP4K2A protein phosphorylates phosphatidylinositol 5-phosphate to form phosphatidylinositol 4,5-bisphosphate. PIP4K2A Protein, Human (HEK293, His) is the recombinant human-derived PIP4K2A protein, expressed by HEK293 , with C-6*His labeled tag. The total length of PIP4K2A Protein, Human (HEK293, His) is 406 a.a., with molecular weight of 52-58 kDa.

HY-P70536

	TNF RII/TNFRSF1B Protein, Human (183a.a, HEK293, mFc) TNF-RII; TNFRII; TNF RII; Tumor necrosis factor receptor superfamily member 1B; TNFRSF1B; Tumor necrosis factor receptor 2; TNF-R2; Tumor necrosis factor receptor type II; p75; p80 TNF-alpha receptor; CD120b	Human	HEK293
	TNFRII (TNFRSF1B) protein has a high ability to bind with tumor necrosis factor-alpha (TNF-α). TNFRII has pro-apoptotic function. TNFRII recruits TRAF2, induces gene expression and intensively crosstalks with TNF-R1. TNFRII selectively enhances the induction of apoptosis by the death receptor TNFRI. TNF RII/TNFRSF1B Protein, Human (183a.a, HEK293, mFc) is expressed by HEK293 and has a transmembrane region (P24-T206) with mFc tag at the C-terminus.

HY-P78091

	CD40 Protein, Human (Biotinylated, HEK293, His-Avi) CD40; CD40L receptor; TNFRSF5; B cell surface antigen CD40; B-cell surface antigen CD40; Bp50B cell-associated molecule; CD40 antigen; CD40 molecule, TNF receptor superfamily member 5; CD40 type II isoform; CDw40; MGC9013; nerve growth factor receptor-relat	Human	HEK293
	CD40 protein is a TNFSF5/CD40LG receptor that transduces signals through TRAF6 and MAP3K8-mediated pathways, activates ERK in macrophages and B cells, and induces immunoglobulin secretion. CD40 exists as monomers and homodimers and interacts with TRAF proteins (TRAF1, TRAF2, TRAF3, TRAF5, and TRAF6). CD40 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived CD40 protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of CD40 Protein, Human (Biotinylated, HEK293, His-Avi) is 173 a.a., with molecular weight of 35-40 kDa.

HY-P70688

	NKG2D/CD314 Protein, Human (HEK293, His) CD314; KLRK1; CD314 antigen; Killer cell lectin-like receptor subfamily K member 1; killer cell lectin-like receptor subfamily K; member 1; KLR; NK cell receptor D; NKG2-D; NKG2-D type II integral membrane protein; NKG2-D-activating NK receptor; NKG2D	Human	HEK293
	The NKG2D/CD314 protein serves as a key activating and costimulatory receptor in immune surveillance, binding to multiple stress-inducing ligands on tumor and virus-infected cells. It plays a dual role by stimulating NK cells and enhancing T cell activation in CD8(+) T cell-mediated adaptive responses. NKG2D/CD314 Protein, Human (HEK293, His) is the recombinant human-derived NKG2D/CD314 protein, expressed by HEK293 , with N-6*His labeled tag. The total length of NKG2D/CD314 Protein, Human (HEK293, His) is 139 a.a., with molecular weight of 20-30 kDa.

Cat. No.	Product Name	Chemical Structure

HY-13635S

Finasteride-d9

Finasteride-d₉ is deuterium labeled Finasteride. Finasteride (MK-906) is a potent and competitive 5α-reductase inhibitor, with an IC50 of 4.2 nM for type II 5α-reductase. Finasteride has approximately a 100-fold greater affinity for type II 5α-reductase enzyme than for the type I enzyme. Finasteride can be used for the research of benign prostatic hyperplasia (BPH) and androgenic alopecia[1][2][3].

HY-10581AS

Gatifloxacin-d3 hydrochloride

Gatifloxacin-d₃ (hydrochloride) is the deuterium labeled Gatifloxacin (hydrochloride). Gatifloxacin hydrochloride (AM-1155; BMS-206584; PD135432) is a potent fluoroquinolone antibiotic with broad-spectrum antibacterial activity. Gatifloxacin hydrochloride inhibits bacterial type II topoisomerases (IC50=13.8 μg/ml for S. aureus topoisomerase IV) and E. coli DNA gyrase (IC50 = 0.109 μg/ml). Gatifloxacin hydrochloride can be used to treat bacterial conjunctivitis in vivo.

Cat. No.	Product Name	Application	Reactivity

HY-P83260

Cytokeratin 8 Antibody (YA3005)

KRT8; CYK8; Keratin; type II cytoskeletal 8; Cytokeratin-8; CK-8; Keratin-8; K8; type-II keratin Kb8
WB, IHC-P, ICC/IF, IP, FC Human, Mouse
HY-P82890

Phospho-Cytokeratin 8 (Ser23) Antibody (YA2635)

KRT8; CYK8; Keratin; type II cytoskeletal 8; Cytokeratin-8; CK-8; Keratin-8; K8; type-II keratin Kb8
WB, IHC-F, IHC-P, ICC/IF, IP Human

HY-P82920

Cytokeratin 1 Antibody (YA2665) 67 kDa cytokeratin; CK1; EHK; Epidermolytic hyperkeratosis 1; EPPK; Hair alpha protein; K1; Keratin; KRT 1; KRT1A; NEPPK; type II cytoskeletal 1; type-II keratin Kb1	WB	Human, Mouse, Rat

HY-P82926

Cytokeratin 2e Antibody (YA2671) KRT2; KRT76; KRT3; KRT5; KRT6A; KRT6B; KRT6C; KRT71; KRT72; KRT73; KRT74; KRT75; KRT79; KRT8; KRT84; Keratin; type II cytoskeletal 2 epidermal; Keratin; type II cytoskeletal 2 oral; Keratin; type II cytoskeletal 3; Keratin; type II cytoskeletal 5; Keratin; type II cytoskeletal 6A; Keratin; type II cytoskeletal 6B; Keratin; type II cytoskeletal 6C; Keratin; type II cytoskeletal 71; Keratin; type II cytoskeletal 72; Keratin; type II cytoskeletal 73; Keratin; type II cytoskeletal 74	WB, IHC-P	Human

HY-P80984

Cytokeratin 5 Antibody CK-5; CK5; Cytokeratin-5; Cytokeratin5; DDD; DDD1; EBS2; epidermolysis bullosa simplex 2 Dowling-Meara/Kobner/Weber-Cockayne types; K2C5_HUMAN; K5; keratin 5 (epidermolysis bullosa simplex, Dowling-Meara/Kobner/Weber-Cockayne types); Keratin 5; Keratin ; keratin complex 2, basic, gene 5; keratin, type II cytoskeletal 5 ; Keratin-5; Keratin5; KRT 5; Krt5; KRT5A; type II cytoskeletal 5 ; type-II keratin Kb5;	WB, IHC-P, IF-Tissue, IF-Cell, FC	Human, Mouse, Rat
Cytokeratin 5 Antibody is an unconjugated, approximately 62 kDa, rabbit-derived, anti-Cytokeratin 5 monoclonal antibody. Cytokeratin 5 Antibody can be used for: WB, IHC-P, IF-Tissue, IF-Cell, FC expriments in human, mouse, rat background without labeling.

HY-P81491

INPP4B Antibody (YA1236) 4-bisphosphate 4-phosphatase; Inositol polyphosphate 4 phosphatase type II 105kDa; Inositol polyphosphate 4-phosphatase type II; Inpp4b; MGC132014; type II inositol 3; 4 bisphosphate 4 phosphatase; type II inositol-3	IHC-P	Human

HY-P81047

Collagen II Antibody Collagen II alpha 1; COL2A1; COL2A1 protein; collagen, type II, alpha 1; collagen alpha-1(II); type II collagen; alpha-1 type II collagen; alpha1 type II collagen; Col2a1; AOM; Cartilage collagen; Chondrocalcin; COL11A3; Collagen alpha 1(II) chain precursor; Collagen II alpha 1 polypeptide; Collagen type II alpha 1 (primary osteoarthritis spondyloepiphyseal dysplasia congenital); MGC131516; SEDC; Collagen alpha-1(II) chain; Alpha-1 type II collagen; CO2A1_HUMAN.; CollagenII;	WB, ELISA, IHC-P, IF	Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit, Guinea Pig
Collagen II Antibody is an unconjugated, approximately 117 KDa, rabbit-derived, anti-Collagen II polyclonal antibody. Collagen II Antibody can be used for: WB, ELISA, IHC-P, IF expriments in human, mouse, rat, chicken, dog, pig, cow, rabbit, guinea pig background without labeling.

HY-P83148

Arginase 2 Antibody (YA2893)

ARG2; Arginase-2; type II arginase
WB, ICC/IF, FC Human

HY-P81111

IFN gamma Antibody IFNG; IFG; IFI; IFN Gamma; IFN Immune; IFN-gamma; IFNG; IFNG_HUMAN; Immune Interferon; Interferon gamma; Interferon Gamma Precursor; Macrophage Activating Factor; MAF; T Cell Interferon; type II Interferon.	WB; ELISA; IHC-P; IHC-F; IF	Human,
IFN gamma Antibody is an unconjugated, approximately 15 kDa, rabbit-derived, anti-IFN gamma polyclonal antibody. IFN gamma Antibody can be used for: WB, ELISA, IHC-P, IHC-F, IF expriments in human, background without labeling.

HY-P81206

SRD5A2 Antibody 5 alpha SR2; EC; SR type 2; Steroid 5 alpha reductase 2; 3 oxo 5 alpha steroid 4 dehydrogenase 2; 3-oxo-5-alpha-steroid 4-dehydrogenase 2; 5 alpha-SR2; 5ART2; e II 5 alpha reductase; EC; MGC138457; Micropenis, included; S5A2_HUMAN; S5AR 2; SR type 2; SRD5A2; Steroid 5 alpha reductase 2; Steroid 5-alpha-reductase 2; Steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2); type II 5-alpha reductase.	ELISA; IHC-P; IHC-F; IF	Human, Mouse, Rat, Pig, Horse
SRD5A2 Antibody is an unconjugated, approximately 28 kDa, rabbit-derived, anti-SRD5A2 polyclonal antibody. SRD5A2 Antibody can be used for: ELISA, IHC-P, IHC-F, IF expriments in (predicted) human, mouse, rat, pig, horse background without labeling.

HY-P80978

PAX6 Antibody

PAX6; AN2; Paired box protein Pax-6; Aniridia type II protein; Oculorhombin
WB, IHC-P, ICC/IF Human, Mouse, Rat

PAX6 Antibody is an antibody targeting to PAX6.

HY-P82599

CaMKII beta Antibody (YA2344) CAMK2B; CAM2; CAMK2; CAMKB; Calcium/calmodulin-dependent protein kinase type II subunit beta; CaM kinase II subunit beta; CaMK-II subunit beta; CAMK2G; CAMK; CAMK-II; CAMKG; Calcium/calmodulin-dependent protein kinase type II subunit gamma	WB	Mouse

HY-P80847

Phospho-PKA RII alpha (Ser99) Antibody PRKAR2A; PKR2; PRKAR2; cAMP-dependent protein kinase type II-alpha regulatory subunit	WB, IHC-P, ICC/IF, IP	Human, Mouse, Rat, Pig
Phospho-PKA RII alpha (Ser99) Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 46 kDa, targeting to Phospho-PKA RII alpha (Ser99). It can be used for WB,IHC-P,ICC/IF,IP assays with tag free, in the background of Human, Mouse, Rat, Pig.

HY-P81131

TGF beta Receptor II Antibody TGF-beta receptor type-2; TGF beta R2; TGFBR2; AAT 3; AAT3; FAA 3; FAA3; HNPCC6; MFS 2; MFS2; RIIC; TAAD 2; TAAD2; TbetaR II; TGF beta receptor type 2; TGF beta receptor type II; TGF beta type II receptor; TGFB R2; TGFbeta RII; TGFBR 2; TGFR 2; TGFR2; Transforming growth factor beta receptor II; Transforming growth factor beta receptor type II. TGF-βRⅡ; TGFβRⅡ; TGF βRⅡ; TGFβ RⅡ.	WB; ELISA; IHC-P; IHC-F; IF	Human, Mouse, Rat, Cow(predicted: Chicken, Pig, Horse, Rabbit, Sheep)
TGF beta Receptor II Antibody is an unconjugated, approximately 62 kDa, rabbit-derived, anti-TGF beta Receptor II polyclonal antibody. TGF beta Receptor II Antibody can be used for: WB, ELISA, IHC-P, IHC-F, IF expriments in human, mouse, rat, cow, and predicted: chicken, pig, horse, rabbit, sheep background without labeling.

HY-P81267

Cytokeratin 7 Antibody (YA950) CK 7; CK-7; ck7; Cytokeratin 7; Cytokeratin-7; Cytokeratin7; D15Wsu77e; K2C7; K2C7_HUMAN; K7; Keratin 55k type II cytoskeletal; Keratin 7; Keratin simple epithelial type 1 k7; Keratin type II cytoskeletal 7	WB, ICC/IF	Human

HY-P81267A

Cytokeratin 7 Antibody (YA951) CK 7; CK-7; ck7; Cytokeratin 7; Cytokeratin-7; Cytokeratin7; D15Wsu77e; K2C7; K2C7_HUMAN; K7; Keratin 55k type II cytoskeletal; Keratin 7; Keratin simple epithelial type 1 k7; Keratin type II cytoskeletal 7	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Mouse, Rat

HY-P81267B

Cytokeratin 7 Antibody (YA952) CK 7; CK-7; ck7; Cytokeratin 7; Cytokeratin-7; Cytokeratin7; D15Wsu77e; K2C7; K2C7_HUMAN; K7; Keratin 55k type II cytoskeletal; Keratin 7; Keratin simple epithelial type 1 k7; Keratin type II cytoskeletal 7	WB, ICC/IF, IP	Human

HY-P80725

iNOS Antibody NOS2; NOS2A; Nitric oxide synthase; inducible; Hepatocyte NOS; HEP-NOS; Inducible NO synthase; Inducible NOS; iNOS; NOS type II; Peptidyl-cysteine S-nitrosylase NOS2	ICC/IF, WB, IHC-F, IHC-P, ELISA	Human, Mouse, Rat
iNOS Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 131 kDa, targeting to iNOS. It can be used for ICC/IF,WB,IHC-F,IHC-P,ELISA assays with tag free, in the background of Human, Mouse, Rat.

HY-P83598

ERAB Antibody (YA3343) HSD17B10; ERAB; HADH2; MRPP2; SCHAD; XH98G2; 3-hydroxyacyl-CoA dehydrogenase type-2; 17-beta-hydroxysteroid dehydrogenase 10; 17-beta-HSD 10; 3-hydroxy-2-methylbutyryl-CoA dehydrogenase; 3-hydroxyacyl-CoA dehydrogenase type II; Endoplasmic	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat

HY-P81149

NKG2D Antibody NKG2-D type II integral membrane protein; KLRK1; natural killer cell group 2D; NKG2-D isoform b; Klrk1; Nkrp2; NKG2-D-activating NK receptor; NK cell receptor D; Killer cell lectin-like receptor subfamily K; NK lectin-like receptor; CD314; CD 314; CD314 antigen; D12S2489E; Killer cell lectin like receptor subfamily K member 1; Killer cell lectin-like receptor subfamily K member 1; KLR; Klrk1; NKG2 D activating NK receptor; NKG2 D type II integral membrane protein; NKG2-D-activating NK receptor; NKG2D_HUMAN; NKLLR; NKR P2; Nkrp2.	WB; ELISA; IHC-P; Flow-Cyt; IF	Human, Mouse(predicted: Rat)
NKG2D Antibody is an unconjugated, approximately 25 kDa, rabbit-derived, anti-NKG2D polyclonal antibody. NKG2D Antibody can be used for: WB, ELISA, IHC-P, Flow-Cyt, IF expriments in human, mouse, and predicted: rat background without labeling.

HY-P80445

CaMKII alpha Antibody 1 Publications Verification Alpha CaMKII; Calcium calmodulin dependent protein kinase II; Calcium/calmodulin dependent protein kinase II alpha B subunit; Calcium/calmodulin dependent protein kinase type II alpha chain; Calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha; Calcium/calmodulin-dependent protein kinase II alpha; Calcium/calmodulin-dependent protein kinase II-alpha; Calcium/calmodulin-dependent protein kinase type II subunit alpha; Calcium/calmodulin-dependent protein kinase type IIA; CaM kinase II alpha chain; CaM kinase II alpha subunit; CaM kinase II subunit alpha; CaMK II alpha subunit; CaMK-II subunit alpha; Camk2a; CAMKA; CaMKII; CaMKIINalpha; EC2.7.11.17; KCC2A_HUMAN; KIAA0968; MGC123320; MGC139375; MGC155201; mKIAA0968; PK2CDD; PKCCD; R74975; zgc:112538; zgc:123320;	WB, IP, FC, IHC-P	Human, Mouse, Rat
CaMKII alpha Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 54 kDa, targeting to CaMKII alpha. It can be used for WB,IP,FC,IHC-P assays with tag free, in the background of Human, Mouse, Rat.

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