1. Membrane Transporter/Ion Channel
    Neuronal Signaling
    Autophagy
  2. nAChR
    Autophagy
  3. A-867744

A-867744 

Cat. No.: HY-12149 Purity: 99.92%
Handling Instructions

A-867744 is a highly potent and selective type II positive allosteric modulator (PAM) of the alpha7 nicotinic acetylcholine receptors (nAChR) with an EC50 of 1.0 μM.

For research use only. We do not sell to patients.

A-867744 Chemical Structure

A-867744 Chemical Structure

CAS No. : 1000279-69-5

Size Price Stock Quantity
10 mM * 1  mL in DMSO USD 138 In-stock
Estimated Time of Arrival: December 31
10 mg USD 125 In-stock
Estimated Time of Arrival: December 31
50 mg USD 420 In-stock
Estimated Time of Arrival: December 31
100 mg USD 750 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Description

A-867744 is a highly potent and selective type II positive allosteric modulator (PAM) of the alpha7 nicotinic acetylcholine receptors (nAChR) with an EC50 of 1.0 μM[1].

IC50 & Target

EC50: 1.0 μM (alpha7 nAChR)[1]

Molecular Weight

402.89

Formula

C₂₀H₁₉ClN₂O₃S

CAS No.

1000279-69-5

SMILES

O=S(C1=CC=C(C=C1)N2C(C)=C(C=C2C3=CC=C(C=C3)Cl)C(CC)=O)(N)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (248.21 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4821 mL 12.4103 mL 24.8207 mL
5 mM 0.4964 mL 2.4821 mL 4.9641 mL
10 mM 0.2482 mL 1.2410 mL 2.4821 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (6.21 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (6.21 mM); Clear solution

*All of the co-solvents are provided by MCE.

Purity: 99.92%

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Keywords:

A-867744A867744A 867744nAChRAutophagyNicotinic acetylcholine receptorsInhibitorinhibitorinhibit

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Product Name:
A-867744
Cat. No.:
HY-12149
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