NKG2D/CD314 Protein, Rhesus Macaque (sf9, His)

NKG2D/CD314 Protein functions as an activating and costimulatory receptor crucial for immunosurveillance, binding to various stress-inducible ligands on autologous tumor cells and virus-infected cells. This engagement triggers stimulatory and costimulatory innate immune responses in activated killer (NK) cells, leading to cytotoxic activity. In CD8(+) T-cell-mediated adaptive immune responses, NKG2D acts as a costimulatory receptor for the T-cell receptor (TCR), amplifying T-cell activation and stimulating perforin-mediated elimination of ligand-expressing tumor cells. The signaling pathway involves calcium influx, resulting in TNF-alpha expression. Additionally, NKG2D participates in NK cell-mediated bone marrow graft rejection and may regulate NK cell differentiation and survival. The protein forms a homodimer through disulfide linkage and can also create a heterohexamer with HCST/DAP10, essential for NK cell surface expression and induction of NK cell-mediated cytotoxicity. Furthermore, NKG2D interacts with CEACAM1, recruiting PTPN6, which dephosphorylates VAV1. This multifaceted interaction network underscores the critical role of NKG2D in immune responses and surveillance.