Copy Link Print Information

Gevokizumab

2 Cited Publications
Revisión del cliente

Based on 2 publication(s) in Google Scholar

Gevokizumab is a potent anti-IL-1β antibody, negatively modulates IL-1β signaling through an allosteric mechanism. Gevokizumab selectively decreases the binding affinity of IL-1β for the IL-1 receptor type I (IL-1RI) signaling receptor instead of IL-1 counter-regulatory decoy receptor (IL-1 receptor type II).

Para uso exclusivo en investigación. No vendemos a pacientes.

  • Pureza : 98.12%
  • No. CAS: 1129435-60-4
  • Peso molecular:145.12 kDa
  • Almacenamiento:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Gevokizumab
  • Experimental Validation Results for Gevokizumab
  • Experimental Validation Results for Gevokizumab
  • Gevokizumab Chemical Structure
    Gevokizumab Chemical Structure
No. CAS: 1129435-60-4
Tamaño
Precio
Stock
Cantidad
Amount: USD 0.00
Please select quantity
or
or

* Seleccione Cantidad antes de agregar artículos.

To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

Data Download
Gevokizumab Product Recommendations:

To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Encuentre su distribuidor local Your local distributor: Hycultec GmbHHycultec
  • Actividad biológica
  • Chemical Information
  • Protocolo
  • Pureza y Documentación
  • Referencias
  • Help & FAQs
Top Publications Citing

Use of MCE Products

Publications Citing Use of MedChemExpress (MCE) Gevokizumab

More

Ver todos los productos específicos de isoformas Interleukin Related

More

Keywords

MOQ
Minimum order quantity
100 mg

Obtener un presupuesto En stock

Other size
Obtener un presupuesto
Please select quantity
Amount: USD 0.00
Sign in to MedChemExpress Inicie sesiòn
Registrar
Sign in to MedChemExpress
Registrar una cuenta nueva

At least 6 characters

Personalize your experience, you are currently not signed in. For a better experience, please create an online profile, you can:

Obtain points redemption prizes
Check out faster
Add multiple shipping locations
View orders
Assay Types
  • 1/16

    Human IgG2 kappa

  • 1/16

    Loaded Gevokizumab on AHC2 biosensor, can bind TIM-3/HAVCR2 Protein, Human (Biotinylated, HEK293, His-Avi, HY-P78217) with an affinity constant of 6.595E-10 M as determined in BLI assay.

  • 1/16

    Flow cytometric analysis of 1.5X106 RAW264.7 cells treated with 50 nM phorbol-12-myristate-13-acetate (PMA, HY-18739) and 5 μg/ml lipopolysaccharide (LPS, HY-D1056) for 24 hours labeling Gevokizumab (HY-P99171, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃, Human IgG2 kappa, Isotype Control (HY-P99002, blue) was used as the isotype control ,cells without incubation with primary antibody were used as the unlabeled control (black).

  • Gevokizumab Chemical Structure
    1/16
  • Gevokizumab
  • Loaded Gevokizumab on AHC2 biosensor, can bind TIM-3/HAVCR2 Protein, Human (Biotinylated, HEK293, His-Avi, HY-P78217) with an affinity constant of 6.595E-10 M as determined in BLI assay.
  • Flow cytometric analysis of 1.5X106 RAW264.7 cells treated with 50 nM phorbol-12-myristate-13-acetate (PMA, HY-18739) and 5 μg/ml lipopolysaccharide (LPS, HY-D1056) for 24 hours labeling Gevokizumab (HY-P99171, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃, Human IgG2 kappa, Isotype Control (HY-P99002, blue) was used as the isotype control ,cells without incubation with primary antibody were used as the unlabeled control (black).