Arginase-2/ARG2 Protein, Mouse (His-SUMO)

Arginase-2 (ARG2) emerges as a multifaceted player in cellular regulation, with a pivotal role in orchestrating extra-urea cycle arginine metabolism and modulating nitric oxide synthesis. Beyond its hepatic functions, ARG2's impact extends to innate and adaptive immune responses, suggesting a critical role in shaping the immune landscape. Notably, it appears to negatively regulate the survival capacity of activated CD4(+) and CD8(+) T cells, exerting influence over inflammation-related signaling in asthmatic airway epithelium. The immune evasion strategies of H. pylori may also involve ARG2, restricting M1 macrophage activation and polyamine metabolism. Additionally, ARG2 contributes to prenatal immune suppression and regulates RPS6KB1 signaling, influencing endothelial cell senescence and inflammation. Intriguingly, ARG2's effects extend to endothelial autophagy and vascular smooth muscle cell senescence and apoptosis, emphasizing its diverse functions independent of its classical enzymatic activity.