Arginase-2/ARG2 Protein, Mouse (His-SUMO)

Arginase-2 (ARG2) is a multifunctional regulator central to the regulation of arginine metabolism and nitric oxide synthesis outside the urea cycle. In addition to its hepatic effects, ARG2 affects innate and adaptive immune responses, negatively affecting the survival of activated CD4(+) and CD8(+) T cells. Arginase-2/ARG2 Protein, Mouse (His-SUMO) is the recombinant mouse-derived Arginase-2/ARG2 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.

Arginase-2 (ARG2) emerges as a multifaceted player in cellular regulation, with a pivotal role in orchestrating extra-urea cycle arginine metabolism and modulating nitric oxide synthesis. Beyond its hepatic functions, ARG2's impact extends to innate and adaptive immune responses, suggesting a critical role in shaping the immune landscape. Notably, it appears to negatively regulate the survival capacity of activated CD4(+) and CD8(+) T cells, exerting influence over inflammation-related signaling in asthmatic airway epithelium. The immune evasion strategies of H. pylori may also involve ARG2, restricting M1 macrophage activation and polyamine metabolism. Additionally, ARG2 contributes to prenatal immune suppression and regulates RPS6KB1 signaling, influencing endothelial cell senescence and inflammation. Intriguingly, ARG2's effects extend to endothelial autophagy and vascular smooth muscle cell senescence and apoptosis, emphasizing its diverse functions independent of its classical enzymatic activity.

Mouse

E. coli

N-6*His;N-SUMO

O08691 (V23-I354)

11847  [NCBI]

Full Length of Mature Protein

VHSVAIVGAPFSRGQKKLGVEYGPAAIREAGLLKRLSRLGCHLKDFGDLSFTNVPQDDPYNNLVVYPRSVGLANQELAEVVSRAVSGGYSCVTMGGDHSLAIGTIIGHARHRPDLCVIWVDAHADINTPLTTVSGNIHGQPLSFLIKELQDKVPQLPGFSWIKPCLSPPNIVYIGLRDVEPPEHFILKNYDIQYFSMREIDRLGIQKVMEQTFDRLIGKRQRPIHLSFDIDAFDPKLAPATGTPVVGGLTYREGVYITEEIHNTGLLSALDLVEVNPHLATSEEEAKATARLAVDVIASSFGQTREGGHIVYDHLPTPSSPHESENEECVRI

≥ 90%, as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.