1. GPCR/G Protein
  2. GPR40
  3. AP5

AP5 

Cat. No.: HY-112603
Handling Instructions

AP5 exhibits potent and selective agonism for the GPR40 receptor with positive allosteric modulation of endogenous ligands (AgoPAM). AP5 demonstrates a rat hIP1 EC50 of 0.49±0.28 nM against the GPR40 receptor.

For research use only. We do not sell to patients.

AP5 Chemical Structure

AP5 Chemical Structure

CAS No. : 1623194-37-5

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Description

AP5 exhibits potent and selective agonism for the GPR40 receptor with positive allosteric modulation of endogenous ligands (AgoPAM). AP5 demonstrates a rat hIP1 EC50 of 0.49±0.28 nM against the GPR40 receptor[1].

IC50 & Target

EC50: 0.49±0.28 nM (GPR40 Receptor)[1]

In Vitro

AP5 is a potent and selective GPR40 AgoPAM that demonstrates excellent in vivo efficacy. In the GK rat oral glucose tolerance test (oGTT), oral administration of AP5 1 h before an oral dextrose challenge shows that AP5 significantly reduces blood glucose levels compared to the vehicle. AP5 is determined to be more efficacious in this model, demonstrating maximally efficacious glucose lowering at a plasma concentration of 4.9 μM at 10 mg/kg[1].

Molecular Weight

461.52

Formula

C₂₈H₂₈FNO₄

CAS No.

1623194-37-5

SMILES

FC1=CC(C2=CC(OC)=NC=C2)=CC=C1[[email protected]@H]3CCC(C=CC([[email protected]](C4CC4)[[email protected]](C)C(O)=O)=C5)=C5O3

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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AP5
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