AM-4668
AM-4668 is a GPR40 agonist for type 2 diabetes. EC50s of 3.6 nM and 36 nM for GPR40 in A9 cells (GPR40 IP3 assay) and CHO cells (GPR40 aequorin assay), respectively.
For research use only. We do not sell to patients.
- Purity: 99.0%
- CAS No.: 1011531-27-3
- Formula: C24H19F3N2O4S
- Molecular Weight:488.48
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
Biological Activity
EC50: 3.6 nM (GPR40, in A9 cells), 36 nM (GPR40, in CHO cells)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A9 | EC50 |
3.6 nM
Compound: 10, AM-4668
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Agonist activity at human GPR40 expressed in mouse A9 cells by inositol phosphate accumulation assay
Agonist activity at human GPR40 expressed in mouse A9 cells by inositol phosphate accumulation assay
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[PMID: 24900872] |
| CHO | EC50 |
36 nM
Compound: 10, AM-4668
|
Agonist activity at human GPR40 expressed in CHO cells by aequorin assay
Agonist activity at human GPR40 expressed in CHO cells by aequorin assay
|
[PMID: 24900872] |
Chemical Information
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CAS No. 1011531-27-3
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Appearance Solid
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Molecular Weight 488.48
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Formula C24H19F3N2O4S
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Color White to off-white
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SMILES
OC(C[C@H](C1=NOC=C1)C(C=C2)=CC=C2OCC(S3)=C(C)N=C3C4=CC=C(C(F)(F)F)C=C4)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Purity & Documentation
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Data Sheet (266 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)