LH-RH (7-10)
LH-RH (7-10) is a tetrapeptide, one of major degradation products of luteinising-hormone releasing hormone (LHRH) via pituitary and hypothalamus. LH-RH (7-10) produced in macrophages, type I-like and type II pneumocytes.
For research use only. We do not sell to patients.
- CAS No.: 38482-71-2
- Formula: C19H36N8O4
- Molecular Weight:440.54
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
The formation of LHRH 4-10, LHRH 7-10, and LHRH 6-10Co-incubation are inhibited by known enzyme inhibitors including Captopril (HY-B0368) (an ACE inhibitor), Thiorphan (HY-W013375) (an EP24.11 inhibitor), and
Ethylenediaminetetraacetic acid (HY-Y0682) (an EP24.15 inhibitor)[3].
LH-RH (7-10) inhibits the binding of 125I-labeled GnRH to monoclonal antibody P81662 with an IC50 value of 1.7 nM[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
LH-RH (7-10) (ntracarotid infusion i.v.; single dose) stimulates a significant increase in plasma LH concentration in the jugular vein[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:New Zealand White Rabbit[2]
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Dosage:100, 500 and 2500 ng dissolved in 0-9% (w/v) NaCl solution and diluted
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Administration:Ntracarotid infusion; infused with a constant volume of 7-5 mL per 30 min
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Result:Caused LH release in the female rabbit during various reproductive conditions.
Chemical Information
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CAS No. 38482-71-2
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Molecular Weight 440.54
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Formula C19H36N8O4
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Sequence Shortening
LRPG-NH2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[2]. Carlson JC, et al. The effect of LH-RH administration on LH release in the female rabbit. J Reprod Fertil. 1979 May;56(1):175-80. [Content Brief]
[3]. Yang X, et al. Enzymatic degradation of luteinizing hormone releasing hormone (LHRH)/[D-Ala6]-LHRH in lung pneumocytes. Pharm Res. 1998 Sep;15(9):1480-4. [Content Brief]
[4]. Talwar GP, et al. Bioeffective monoclonal antibody against the decapeptide gonadotropin-releasing hormone: reacting determinant and action on ovulation and estrus suppression. Proc Natl Acad Sci U S A. 1985 Feb;82(4):1228-31. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
LH-RH (7-10) Related Classifications
HY-P3674 Related Classifications
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