B-Raf IN 17
B-Raf IN 17 (Compound 8e) is a potent and orally active type II multi-kinase inhibitor. B-Raf IN 17 exhibits potent cellular-level suppression of BRAFWT, VEGFR-2, and FGFR-1 in A375 cell line, with IC50 values of 0.02, 0.18 and 1.65 μM, respectively. B-Raf IN 17 can be used for the research of cancer.
For research use only. We do not sell to patients.
- Formula: C22H14BrN5O2
- Molecular Weight:460.28
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Biological Activity
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6 mice bearing B16F10 cells
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Dosage:10-20mg/kg
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Administration:p.o., three time pre week for 21 days
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Result:Prolonged the overall survival time.
Reduced angiogenesis markers, mRNA expression levels of VEGFR-2 and FGFR-1, and production of growth factors.
Downregulated Notch1 protein expression and decreased TGF-β1 production.
Chemical Information
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Molecular Weight 460.28
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Formula C22H14BrN5O2
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SMILES
O=C(C1=CC=C2NC(C3=CC=CC=C3)=NC2=C1)N/N=C4C(NC5=C/4C=C(C=C5)Br)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
B-Raf IN 17 Related Classifications
HY-158027 Related Classifications
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