1. Protein Tyrosine Kinase/RTK
  2. Bcr-Abl
  3. CHMFL-ABL-121

CHMFL-ABL-121 

Cat. No.: HY-119370
Handling Instructions

CHMFL-ABL-121 is a highly potent type II ABL kinase inhibitor with IC50s of 2 nM and 0.2 nM against purified inactive ABL wt and T315I kinase protein, respectively.

For research use only. We do not sell to patients.

CHMFL-ABL-121 Chemical Structure

CHMFL-ABL-121 Chemical Structure

CAS No. : 2270879-07-5

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Description

CHMFL-ABL-121 is a highly potent type II ABL kinase inhibitor with IC50s of 2 nM and 0.2 nM against purified inactive ABL wt and T315I kinase protein, respectively[1].

IC50 & Target[1]

ABL wt

2 nM (IC50)

In Vitro

CHMFL-ABL-121 dose-dependently inhibits BCRABL's auto-phosphorylation at Y245 site in K562 (EC50 < 10 nM), MEG-01 (EC50 < 10 nM) and KU812 (EC50 < 30 nM) cells and also significantly blocks the phosphorylation of downstream signaling mediators STAT5, CrkL and ErK[1].
CHMFL-ABL-121 induces apoptosis and arrests cell cycle at G0/G1 phase[1].

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Molecular Weight

580.67

Formula

C₃₀H₃₁F₃N₆OS

CAS No.

2270879-07-5

SMILES

O=C(NC1=CC(C(F)(F)F)=C(CN2CCN(C)CC2)C=C1)CCSC3=CC(NN=C4/C=C/C5=CC=CC=N5)=C4C=C3

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
CHMFL-ABL-121
Cat. No.:
HY-119370
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CHMFL-ABL-121

Cat. No.: HY-119370