1. Cell Cycle/DNA Damage
  2. CDK
  3. AUZ 454

AUZ 454 (Synonyms: K03861)

Cat. No.: HY-15004 Purity: 99.99%
Handling Instructions

AUZ 454 (K03861) is a type II CDK2 inhibitor with Kd of 8.2 nM. AUZ 454 (K03861) inhibits CDK2 activity by competing with binding of activating cyclins.

For research use only. We do not sell to patients.

AUZ 454 Chemical Structure

AUZ 454 Chemical Structure

CAS No. : 853299-07-7

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 199 In-stock
Estimated Time of Arrival: December 31
2 mg USD 120 In-stock
Estimated Time of Arrival: December 31
5 mg USD 180 In-stock
Estimated Time of Arrival: December 31
10 mg USD 312 In-stock
Estimated Time of Arrival: December 31
25 mg USD 648 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1092 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

AUZ 454 (K03861) is a type II CDK2 inhibitor with Kd of 8.2 nM. AUZ 454 (K03861) inhibits CDK2 activity by competing with binding of activating cyclins.

IC50 & Target

CDK2(C118L/A144C)

9.7 nM (Kd)

CDK2(A144C)

15.4 nM (Kd)

CDK2(C118L)

18.6 nM (Kd)

CDK2(WT)

50 nM (Kd)

CDK2(C118L/A144C-Cyclin B)

134.1 nM (Kd)

Molecular Weight

501.50

Formula

C₂₄H₂₆F₃N₇O₂

CAS No.

853299-07-7

SMILES

NC1=NC(OC2=CC=C(NC(NC3=CC(C(F)(F)F)=C(CN4CCN(C)CC4)C=C3)=O)C=C2)=CC=N1

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 33 mg/mL (65.80 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9940 mL 9.9701 mL 19.9402 mL
5 mM 0.3988 mL 1.9940 mL 3.9880 mL
10 mM 0.1994 mL 0.9970 mL 1.9940 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 1.67 mg/mL (3.33 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 1.67 mg/mL (3.33 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 1.67 mg/mL (3.33 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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AUZ 454
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HY-15004
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