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Referencia número: HY-160628

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GPR120 Agonist 4

GPR120 Agonist 4 (example 1) is a GPR120 agonist，with the EC₅₀ values of 1 μM and 0.35 μM for β-arrestin A and Calcium A. GPR120 Agonist 4 can be used for the research of type II diabetes mellitus.

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No. CAS: 1628641-89-3
Fòrmula: C₂₁H₁₅ClF₅NO₃
Peso molecular:459.79

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

GPR120 Agonist 4 Chemical Structure

No. CAS: 1628641-89-3

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
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Actividad biológica

Descripciòn

IC₅₀ & Target

GPR120

1 μM (EC₅₀)

Ver todos los productos específicos de isoformas Free Fatty Acid Receptor :

In Vitro

GPR120 Agonist 4 (example 1) (0.012-25 μM, 90 min) can activate GPR120 through recruitment of β-Arrestin in CHO-K1 GPR120 β-Arrestin cells^[1].
GPR120 Agonist 4 (0.012-25 μM, 90 min) promotes the release of Ca²⁺ in HEK293 with human GPR120 clone, which verifies the activation effect of GPR120 Agonist 4 on GPR120^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

GPR120 Agonist 4 (example 1) (0.2/0.3/1/3/10 mg/kg, i.p., 15/30/45/60/90 min) dose-dependently promotes a decrease in glucose levels of the high fat diet mice model^[1].
GPR120 Agonist 4 (1/3/10 mg/kg, i.p., 15/30/45/60/90 min) inhibits the glucose level of starvation mouse model in a dose-dependent manner^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Research Protocol for Metabolic Diseases

Chemical Information

No. CAS 1628641-89-3
Peso molecular 459.79
Fòrmula C₂₁H₁₅ClF₅NO₃
SMILES

O=C(CCC1=CC(F)=C(C(F)=C1)OCC2=C(C(F)(F)F)C=CN2C3=CC=C(C=C3)Cl)O
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. SUI, Zhihua, et al. Bicyclic pyrrole derivatives useful as agonists of gpr120. WO2015134038. 2014-03-07

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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