PTP1B-IN-15
Based on 1 Customer Validation
PTP1B-IN-15 is a potent and selective inhibitor of protein tyrosine phosphatase 1B (PTP1B). PTP1B-IN-15 has the potential for the research of type II diabetes and obesity.
For research use only. We do not sell to patients.
- Purity : 99.95%
- CAS No.: 765317-71-3
- Formula: C19H17Br2NO5S
- Molecular Weight:531.21
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
PTP1B[1]
Chemical Information
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CAS No. 765317-71-3
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Appearance Solid
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Molecular Weight 531.21
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Formula C19H17Br2NO5S
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Color White to off-white
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SMILES
CCC1=C(C(C2=CC(Br)=C(O)C(Br)=C2)=O)C(C=CC(S(=O)(N(C)C)=O)=C3)=C3O1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
In Vitro:
DMSO : 250 mg/mL (470.62 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Protocols
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Research Protocol for Metabolic Diseases
AMP-activated protein kinase, AMPK, is a conserved cellular energy sensor that responds to reduced cellular energy status and coordinates metabolism by increasing ATP-generating catabolic pathways while suppressing ATP-consuming anabolic processes. In metabolic disease research, the AMPK pathway is experimentally relevant because it regulates hepatic lipid synthesis, fatty acid oxidation, glucose production, skeletal-muscle glucose disposal, mTORC1-linked biosynthesis, autophagy, mitochondrial homeostasis, and whole-body energy balance. The central pathway logic is that energy stress, metformin, exercise-like stimulation, or direct AMPK activators increase AMPKα Thr172 phosphorylation and downstream substrate phosphorylation, including ACC and RAPTOR. Phosphorylation of ACC suppresses lipogenesis and supports fatty acid oxidation, whereas phosphorylation of RAPTOR suppresses mTORC1 signaling and links cellular energy status to growth and protein synthesis control. The pathway is linked
Purity & Documentation
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Data Sheet (271 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 1.8825 mL | 9.4125 mL | 18.8249 mL | 47.0624 mL |
| 5 mM | 0.3765 mL | 1.8825 mL | 3.7650 mL | 9.4125 mL | |
| 10 mM | 0.1882 mL | 0.9412 mL | 1.8825 mL | 4.7062 mL | |
| 15 mM | 0.1255 mL | 0.6275 mL | 1.2550 mL | 3.1375 mL | |
| 20 mM | 0.0941 mL | 0.4706 mL | 0.9412 mL | 2.3531 mL | |
| 25 mM | 0.0753 mL | 0.3765 mL | 0.7530 mL | 1.8825 mL | |
| 30 mM | 0.0627 mL | 0.3137 mL | 0.6275 mL | 1.5687 mL | |
| 40 mM | 0.0471 mL | 0.2353 mL | 0.4706 mL | 1.1766 mL | |
| 50 mM | 0.0376 mL | 0.1882 mL | 0.3765 mL | 0.9412 mL | |
| 60 mM | 0.0314 mL | 0.1569 mL | 0.3137 mL | 0.7844 mL | |
| 80 mM | 0.0235 mL | 0.1177 mL | 0.2353 mL | 0.5883 mL | |
| 100 mM | 0.0188 mL | 0.0941 mL | 0.1882 mL | 0.4706 mL |
PTP1B-IN-15 Related Classifications
HY-108196 Related Classifications
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