Axl-IN-18
Axl-IN-18 (compound 25c) is a potent and selective type II AXL inhibitor. Axl-IN-18 shows excellent AXL inhibitory activity (IC50=1.1 nM) and 343-fold selectivity over the highly homologous kinase MET in biochemical assays (IC50=377 nM). Axl-IN-18 significantly inhibits AXL-driven cell proliferation, dose-dependently suppresses 4T1 cell migration and invasion, and induces apoptosis. Axl-IN-18 shows noticeable antitumor efficacy in a BaF3/TEL-AXL xenograft model.
For research use only. We do not sell to patients.
- CAS No.: 3040329-68-5
- Formula: C32H26FN5O4
- Molecular Weight:563.58
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| EBC-1 | IC50 |
1805.7 nM
Compound: 25c
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Antiproliferative activity against human EBC-1 cells
Antiproliferative activity against human EBC-1 cells
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[PMID: 38169272] |
Chemical Information
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CAS No. 3040329-68-5
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Molecular Weight 563.58
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Formula C32H26FN5O4
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SMILES
O=C1C2=C(NC3=CC(F)=C(OC4=C(C=C(OC)C(OC)=C5)C5=NC=N4)C=C3)N=CC=C2N(C)C=C1C6=CC=CC(C)=C6
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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