3040329-68-5
Chemical Structure
Axl-IN-18
- CAS No.: 3040329-68-5
- Formula:C32H26FN5O4
- Molecular Weight:563.58
InChIKey: TZFAMUMVJZGJNK-UHFFFAOYSA-N
SMILES: O=C1C2=C(NC3=CC(F)=C(OC4=C(C=C(OC)C(OC)=C5)C5=NC=N4)C=C3)N=CC=C2N(C)C=C1C6=CC=CC(C)=C6
Biological Activity: Axl-IN-18 (compound 25c) is a potent and selective type II AXL inhibitor. Axl-IN-18 shows excellent AXL inhibitory activity (IC50=1.1 nM) and 343-fold selectivity over the highly homologous kinase MET in biochemical assays (IC50=377 nM). Axl-IN-18 significantly inhibits AXL-driven cell proliferation, dose-dependently suppresses 4T1 cell migration and invasion, and induces apoptosis. Axl-IN-18 shows noticeable antitumor efficacy in a BaF3/TEL-AXL xenograft model[1].
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Axl-IN-18 | Axl-IN-18 (compound 25c) is a potent and selective type II AXL inhibitor. Axl-IN-18 shows excellent AXL inhibitory activity (IC50=1.1 nM) and 343-fold selectivity over the highly homologous kinase MET in biochemical assays (IC50=377 nM). Axl-IN-18 significantly inhibits AXL-driven cell proliferation, dose-dependently suppresses 4T1 cell migration and invasion, and induces apoptosis. Axl-IN-18 shows noticeable antitumor efficacy in a BaF3/TEL-AXL xenograft model. | |||||||||||||||||||||
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Keywords
