MB327
MB327 is a bipyridine nonoxime compound that restores neuromuscular function. MB327 restores the activity of nicotinamide acetylcholine receptors (nAChRs) for carbachol desensitization in a typical type II PAM manner. MB327 can neutralize nerve agent poisoning.
For research use only. We do not sell to patients.
- CAS No.: 61368-98-7
- Formula: C21H32I2N2
- Molecular Weight:566.30
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Chemical Information
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CAS No. 61368-98-7
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Molecular Weight 566.30
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Formula C21H32I2N2
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SMILES
CC(C)(C)C1=CC=[N+](CCC[N+]2=CC=C(C(C)(C)C)C=C2)C=C1.[I-].[I-]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Niessen K V, et al. In vitro pharmacological characterization of the bispyridinium non-oxime compound MB327 and its 2-and 3-regioisomers[J]. Toxicology Letters, 2018, 293: 190-197. [Content Brief]
[2]. Seeger T, et al. Restoration of soman-blocked neuromuscular transmission in human and rat muscle by the bispyridinium non-oxime MB327 in vitro[J]. Toxicology, 2012, 294(2-3): 80-84. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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