2. MAPK/ERK Pathway Autophagy Anti-infection
  3. p38 MAPK Autophagy HCV
  4. ITX5061

ITX5061 is a type II inhibitor of p38 MAPK and also an antagonist of scavenger receptor B1 (SR-B1).

For research use only. We do not sell to patients.

ITX5061 Chemical Structure

ITX5061 Chemical Structure

CAS No. : 1252679-52-9

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5 mg USD 650 In-stock
10 mg USD 980 In-stock
50 mg USD 3000 In-stock
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Customer Review

Based on 2 publication(s) in Google Scholar

ITX5061 Related Antibodies

Top Publications Citing Use of Products

View All p38 MAPK Isoform Specific Products:

View All Isoforms
p38 MAPK p38α p38β MAPK13 p38δ p38γ

  • Biological Activity

  • Protocol

  • Purity & Documentation

  • References

  • Customer Review

Description

ITX5061 is a type II inhibitor of p38 MAPK and also an antagonist of scavenger receptor B1 (SR-B1).

IC50 & Target

p38 MAPK, SR-B1[1]
In Vivo

ITX5061 is a type II inhibitor of p38 MAPK and also an antagonist of scavenger receptor B1 (SR-B1). Treatment of ITX5061 (30 mg/kg/day) for mice results in a 50% increase in HDL-C levels compare to baseline. ApoA-I levels are moderately (+15 %) but significantly increased in ITX5061-treated HuAITg mice, compare to mice receive vehicle. ITX5061 significantly decreases HDL-CE catabolism with an FCR of 1.86±0.40 pools/d vs 2.47±0.26 pools/d in the control group (P<0.05), while calculated production rates are identical in both groups (129±24 μg/g/d vs 129±16 μg/g/d). Moreover, accumulation of [3H] CE in the liver is significantly lower in ITX5061-treated mice indicating that increased HDL-CE levels are due to reduced uptake by the liver[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

620.16

Formula

C30H38ClN3O7S
CAS No.
Appearance

Solid

Color

Light yellow to light brown

SMILES

O=C(NC1=CC(C(C)(C)C)=CC(NS(=O)(C)=O)=C1OC)C(C2=C3C=CC=CC3=C(OCCN4CCOCC4)C=C2)=O.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 83.3 mg/mL (134.32 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6125 mL 8.0624 mL 16.1249 mL
5 mM 0.3225 mL 1.6125 mL 3.2250 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.38%

COA (254 KB) LCMS (111 KB)

Handling Instructions (2659 KB)
References
Animal Administration
[1]

Atherosclerosis studies are conducted in F1 hybrid C57BL/6×DBA/1 Ldlr+/- mice fed the Paigen diet, which is high-fat/cholesterol/bile salt diet containing 1.25% cholesterol, 7.5% cocoa butter, and 0.5% cholic acid. For 18 weeks, the mice are put on the Paigen diet with or without ITX5061 at 0.037 %. CETP expression is induced by injection of adeno-associated virus (AAV)8 TBG human CETP vector two weeks before starting the Paigen diet. Doses of virus are given by IP injection[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.6125 mL 8.0624 mL 16.1249 mL 40.3122 mL
5 mM 0.3225 mL 1.6125 mL 3.2250 mL 8.0624 mL
10 mM 0.1612 mL 0.8062 mL 1.6125 mL 4.0312 mL
15 mM 0.1075 mL 0.5375 mL 1.0750 mL 2.6875 mL
20 mM 0.0806 mL 0.4031 mL 0.8062 mL 2.0156 mL
25 mM 0.0645 mL 0.3225 mL 0.6450 mL 1.6125 mL
30 mM 0.0537 mL 0.2687 mL 0.5375 mL 1.3437 mL
40 mM 0.0403 mL 0.2016 mL 0.4031 mL 1.0078 mL
50 mM 0.0322 mL 0.1612 mL 0.3225 mL 0.8062 mL
60 mM 0.0269 mL 0.1344 mL 0.2687 mL 0.6719 mL
80 mM 0.0202 mL 0.1008 mL 0.2016 mL 0.5039 mL
100 mM 0.0161 mL 0.0806 mL 0.1612 mL 0.4031 mL
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ITX5061 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ITX50611252679-52-9ITX 5061ITX-5061p38 MAPKAutophagyHCVHepatitis C virusInhibitorinhibitorinhibit

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