1. Protein Tyrosine Kinase/RTK
  2. c-Fms
  3. JTE-952

JTE-952 is a potent, oral active and selective Type II inhibitor of colony stimulating factor-1 receptor (CSF-1R or cFMS, type III receptor tyrosine kinase), with IC50 values of 13 nM and 261 nM for CSF1R and TrkA , respectively. Effective against a mouse collagen-induced model of arthritis.

For research use only. We do not sell to patients.

JTE-952 Chemical Structure

JTE-952 Chemical Structure

CAS No. : 1255303-54-8

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
USD 565 In-stock
Solution
10 mM * 1 mL in DMSO USD 565 In-stock
Solid
5 mg USD 495 In-stock
10 mg USD 790 In-stock
25 mg USD 1660 In-stock
50 mg USD 2656 In-stock
100 mg   Get quote  
200 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

JTE-952 is a potent, oral active and selective Type II inhibitor of colony stimulating factor-1 receptor (CSF-1R or cFMS, type III receptor tyrosine kinase), with IC50 values of 13 nM and 261 nM for CSF1R and TrkA , respectively. Effective against a mouse collagen-induced model of arthritis[1].

IC50 & Target

IC50: 13 nM (CSF1R), 261 nM (TrkA)[1].

In Vivo

JTE-952 (3 mg/kg, p.o. once-daily) treatment reduces the overall progression of the clinical score, including inflammation and bone erosion in mouse model of collagen-induced arthritis (CIA model)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mouse model of collagen-induced arthritis (CIA model)[1].
Dosage: 3 mg/kg.
Administration: Oral once-daily.
Result: Reduced the overall progression of the clinical score, including inflammation and bone erosion.
Molecular Weight

518.60

Formula

C30H34N2O6

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(N1CC(C2=CC=C(OCC3=CC=C(C4CC4)C=C3)C(OC)=C2)C1)C5=NC=CC(COC[C@@H](O)CO)=C5

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (192.83 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9283 mL 9.6413 mL 19.2827 mL
5 mM 0.3857 mL 1.9283 mL 3.8565 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9283 mL 9.6413 mL 19.2827 mL 48.2067 mL
5 mM 0.3857 mL 1.9283 mL 3.8565 mL 9.6413 mL
10 mM 0.1928 mL 0.9641 mL 1.9283 mL 4.8207 mL
15 mM 0.1286 mL 0.6428 mL 1.2855 mL 3.2138 mL
20 mM 0.0964 mL 0.4821 mL 0.9641 mL 2.4103 mL
25 mM 0.0771 mL 0.3857 mL 0.7713 mL 1.9283 mL
30 mM 0.0643 mL 0.3214 mL 0.6428 mL 1.6069 mL
40 mM 0.0482 mL 0.2410 mL 0.4821 mL 1.2052 mL
50 mM 0.0386 mL 0.1928 mL 0.3857 mL 0.9641 mL
60 mM 0.0321 mL 0.1607 mL 0.3214 mL 0.8034 mL
80 mM 0.0241 mL 0.1205 mL 0.2410 mL 0.6026 mL
100 mM 0.0193 mL 0.0964 mL 0.1928 mL 0.4821 mL
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
JTE-952
Cat. No.:
HY-122906
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