1. Protein Tyrosine Kinase/RTK
  2. c-Fms

JTE-952 

Cat. No.: HY-122906
Handling Instructions

JTE-952 is a potent, oral active and selective inhibitor of colony stimulating factor-1 receptor (CSF-1R or cFMS, type III receptor tyrosine kinase) Type II, with IC50 values of 13 nM and 261 nM for CSF1R and TrkA , respectively. Effective against a mouse collagen-induced model of arthritis.

For research use only. We do not sell to patients.

JTE-952 Chemical Structure

JTE-952 Chemical Structure

CAS No. : 1255303-54-8

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  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

JTE-952 is a potent, oral active and selective inhibitor of colony stimulating factor-1 receptor (CSF-1R or cFMS, type III receptor tyrosine kinase) Type II, with IC50 values of 13 nM and 261 nM for CSF1R and TrkA , respectively. Effective against a mouse collagen-induced model of arthritis[1].

IC50 & Target

IC50: 13 nM (CSF1R), 261 nM (TrkA)[1].

In Vivo

JTE-952 (3 mg/kg, p.o. once-daily) treatment reduces the overall progression of the clinical score, including inflammation and bone erosion in mouse model of collagen-induced arthritis (CIA model)[1].

Animal Model: Mouse model of collagen-induced arthritis (CIA model)[1].
Dosage: 3 mg/kg.
Administration: Oral once-daily.
Result: Reduced the overall progression of the clinical score, including inflammation and bone erosion.
Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9283 mL 9.6413 mL 19.2827 mL
5 mM 0.3857 mL 1.9283 mL 3.8565 mL
10 mM 0.1928 mL 0.9641 mL 1.9283 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

518.60

Formula

C₃₀H₃₄N₂O₆

CAS No.

1255303-54-8

SMILES

O=C(N1CC(C2=CC=C(OCC3=CC=C(C4CC4)C=C3)C(OC)=C2)C1)C5=NC=CC(COC[[email protected]@H](O)CO)=C5

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
JTE-952
Cat. No.:
HY-122906
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JTE-952

Cat. No.: HY-122906