1255303-54-8
Chemical Structure
JTE-952
- CAS No.: 1255303-54-8
- Formula:C30H34N2O6
- Molecular Weight:518.60
IUPAC Name: (S)-(3-(4-((4-cyclopropylbenzyl)oxy)-3-methoxyphenyl)azetidin-1-yl)(4-((2,3-dihydroxypropoxy)methyl)pyridin-2-yl)methanone
InChIKey: LTTJGQBDGMNWHJ-SANMLTNESA-N
SMILES: O=C(N1CC(C2=CC=C(OCC3=CC=C(C4CC4)C=C3)C(OC)=C2)C1)C5=NC=CC(COC[C@@H](O)CO)=C5
Biological Activity: JTE-952 is a potent, oral active and selective Type II inhibitor of colony stimulating factor-1 receptor (CSF-1R or cFMS, type III receptor tyrosine kinase), with IC50 values of 13 nM and 261 nM for CSF1R and TrkA , respectively. Effective against a mouse collagen-induced model of arthritis[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
JTE-952 | 99.86% | JTE-952 is a potent, oral active and selective Type II inhibitor of colony stimulating factor-1 receptor (CSF-1R or cFMS, type III receptor tyrosine kinase), with IC50 values of 13 nM and 261 nM for CSF1R and TrkA , respectively. Effective against a mouse collagen-induced model of arthritis. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
Keywords
