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Results for "

and schizophrenia

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (99) AAK1 (1) Adenylate Cyclase (1) Adrenergic Receptor (35) Akt (1) Amino Acid Oxidase (1) Amino acid Transporter (1) Aminopeptidase (1) Amyloid-β (1) Apoptosis (8) Arrestin (1) ASCT (2) Autophagy (12) Bcl-2 Family (1) Biochemical Assay Reagents (6) Calcium Channel (6) CaMK (5) Carboxypeptidase (1) Caspase (2) CCR (2) CD276/B7-H3 (1) Cholecystokinin Receptor (1) Cholinesterase (ChE) (1) COX (2) Cytochrome P450 (7) Dengue Virus (1) Dopamine Receptor (137) Dopamine Transporter (1) Dopamine β-hydroxylase (2) Drug Derivative (5) Drug Intermediate (6) Drug Isomer (2) Drug Metabolite (13) EAAT (1) Endogenous Metabolite (22) Epigenetic Reader Domain (2) ERK (5) Flavivirus (1) FOXO (1) G Protein-coupled Receptor Kinase (GRK) (1) GABA Receptor (7) Glucocorticoid Receptor (1) Glutamate Dehydrogenase (GLDH) (1) Glycosidase (1) GlyT (17) GPR139 (2) GSK-3 (1) Histamine Receptor (13) Histone Demethylase (2) iGluR (14) Imidazoline Receptor (1) Influenza Virus (5) Interleukin Related (3) Isotope-Labeled Compounds (25) Ligands for E3 Ligase (1) mAChR (37) MAP4K (1) mGluR (16) mTOR (2) nAChR (34) NADPH Oxidase (2) Neurokinin Receptor (7) Neurotensin Receptor (3) NF-κB (3) NO Synthase (2) Nucleoside Antimetabolite/Analog (1) Orexin Receptor (OX Receptor) (1) Oxytocin Receptor (2) P-glycoprotein (5) PACAP Receptor (2) PDGFR (2) Phosphodiesterase (PDE) (18) PI3K (4) PKA (1) PKC (1) Potassium Channel (7) Protein Prenyltransferase (1) Reactive Oxygen Species (ROS) (1) Reference Standards (45) ROCK (1) Serotonin Transporter (1) Sigma Receptor (2) SOD (2) Sodium Channel (3) Taste Receptor (1) TNF Receptor (3) Trace Amine-associated Receptor (TAAR) (12) Transmembrane Glycoprotein (1) Xanthine Oxidase (1) β-catenin (4)
By Research Areas:	Cancer (43) Cardiovascular Disease (10) Endocrinology (8) Infection (5) Inflammation/Immunology (15) Metabolic Disease (22) Neurological Disease (377)

By Targets:

5-HT Receptor (99)

AAK1 (1)

Adenylate Cyclase (1)

Adrenergic Receptor (35)

Akt (1)

Amino Acid Oxidase (1)

Amino acid Transporter (1)

Aminopeptidase (1)

Amyloid-β (1)

Apoptosis (8)

Arrestin (1)

ASCT (2)

Autophagy (12)

Bcl-2 Family (1)

Biochemical Assay Reagents (6)

Calcium Channel (6)

CaMK (5)

Carboxypeptidase (1)

Caspase (2)

CCR (2)

CD276/B7-H3 (1)

Cholecystokinin Receptor (1)

Cholinesterase (ChE) (1)

COX (2)

Cytochrome P450 (7)

Dengue Virus (1)

Dopamine Receptor (137)

Dopamine Transporter (1)

Dopamine β-hydroxylase (2)

Drug Derivative (5)

Drug Intermediate (6)

Drug Isomer (2)

Drug Metabolite (13)

EAAT (1)

Endogenous Metabolite (22)

Epigenetic Reader Domain (2)

ERK (5)

Flavivirus (1)

FOXO (1)

G Protein-coupled Receptor Kinase (GRK) (1)

GABA Receptor (7)

Glucocorticoid Receptor (1)

Glutamate Dehydrogenase (GLDH) (1)

Glycosidase (1)

GlyT (17)

GPR139 (2)

GSK-3 (1)

Histamine Receptor (13)

Histone Demethylase (2)

iGluR (14)

Imidazoline Receptor (1)

Influenza Virus (5)

Interleukin Related (3)

Isotope-Labeled Compounds (25)

Ligands for E3 Ligase (1)

mAChR (37)

MAP4K (1)

mGluR (16)

mTOR (2)

nAChR (34)

NADPH Oxidase (2)

Neurokinin Receptor (7)

Neurotensin Receptor (3)

NF-κB (3)

NO Synthase (2)

Nucleoside Antimetabolite/Analog (1)

Orexin Receptor (OX Receptor) (1)

Oxytocin Receptor (2)

P-glycoprotein (5)

PACAP Receptor (2)

PDGFR (2)

Phosphodiesterase (PDE) (18)

PI3K (4)

PKA (1)

PKC (1)

Potassium Channel (7)

Protein Prenyltransferase (1)

Reactive Oxygen Species (ROS) (1)

Reference Standards (45)

ROCK (1)

Serotonin Transporter (1)

Sigma Receptor (2)

SOD (2)

Sodium Channel (3)

Taste Receptor (1)

TNF Receptor (3)

Trace Amine-associated Receptor (TAAR) (12)

Transmembrane Glycoprotein (1)

Xanthine Oxidase (1)

β-catenin (4)

By Research Areas:

Cancer (43)

Cardiovascular Disease (10)

Endocrinology (8)

Infection (5)

Inflammation/Immunology (15)

Metabolic Disease (22)

Neurological Disease (377)

399

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-12472

Balipodect 2 Publications Verification TAK-063	Phosphodiesterase (PDE)	Infection Neurological Disease Cancer
Balipodect (TAK-063) is a selective, brain-penetrant and orally active PDE10A inhibitor with an IC₅₀ of 0.30 nM. Balipodect shows >15000-fold selectivity over other PDEs. Balipodect elevates striatal cAMP and cGMP levels in mice. Balipodect can be used for the study of schizophrenia_[1].

HY-138935

Iclepertin 3 Publications Verification BI-425809	GlyT	Neurological Disease
Iclepertin (BI-425809) is a potent, selective and orally active glycine transporter 1 (GlyT1) inhibitor. Iclepertin is inactive against GlyT2. Iclepertin can be used for Alzheimer disease and schizophrenia research .

HY-10933

CX516 2 Publications Verification BDP 12	iGluR	Neurological Disease
CX516 (BDP 12) is an ampakine and acts as an AMPA receptor positive allosteric modulator for the research of Alzheimer's disease, schizophrenia and mild cognitive impairment (MCI) .

HY-17410

Iloperidone 2 Publications Verification HP 873	5-HT Receptor Dopamine Receptor	Neurological Disease
Iloperidone (HP 873) is a D₂/5-HT₂ receptor antagonist. Iloperidone is an atypical antipsychotic for the schizophrenia symptoms .

HY-153093

Elpipodect MK-8189	Phosphodiesterase (PDE)	Neurological Disease
Elpipodect (MK-8189) is an orally active and selective PDE10A inhibitor with a K_i value of 29 pM. Elpipodect can be used in research of schizophrenia .

HY-B1655

Fluspirilene 2 Publications Verification R 6218; Redeptin	Calcium Channel	Neurological Disease
Fluspirilene is a non-competitive antagonist of L-type calcium channels with an IC₅₀ of 0.03 μM. Fluspirileneis a long-acting injectable depot antipsychotic agent used for schizophrenia.

HY-B1904

Fluphenazine decanoate	Dopamine Receptor	Neurological Disease
Fluphenazine decanoate is a CNS-penetrant dopamine D₂ receptor inhibitor, is a long-acting phenothiazine neuroleptic. Fluphenazine can be used for schizophrenia research .

HY-132228

Zelatriazin TAK-041; NBI-1065846	GPR139	Neurological Disease
Zelatriazin (TAK-041; NBI-1065846) is a potent and selective GPR139 agonist with an EC₅₀ of 22 nM. Zelatriazin has the potential for the research of negative symptoms associated with schizophrenia .

HY-W009390

DL-Homocystine	Endogenous Metabolite	Metabolic Disease
DL-Homocystine is the double-bonded form of homocysteine and homocysteine is recognized as an important substance in the pathogenesis and pathophysiology of schizophrenia.

HY-119943

PF-06256142 1 Publications Verification	Dopamine Receptor	Neurological Disease
PF-06256142 is a potent, selective, CNS-penetrant and orally active agonist of the D1 receptor, with an EC₅₀ and K_i of 33 nM and 12 nM, respectively. PF-06256142 has the potential for the research of schizophrenia and Parkinson's disease .

HY-108698

Preclamol hydrochloride (-)-3-PPP hydrochloride	Dopamine Receptor	Neurological Disease
Preclamol hydrochloride ((-)-3-PPP hydrochloride) is a selective dopamine autoreceptor agonist. Preclamol hydrochloride has the potential for the research of schizophrenia .

HY-14551

Osanetant SR142801	Neurokinin Receptor	Neurological Disease
Osanetant (SR142801) is a selective NK3 receptor antagonist. Osanetant produces anxiolytic- and antidepressant-like effects and is researched for schizophrenia .

HY-120023

VU0453595 2 Publications Verification	mAChR	Neurological Disease
VU0453595 is a highly selective, systemically active M₁ positive allosteric modulator (PAM, EC₅₀=2140 nM) for the research of schizophrenia .

HY-42346

ZH8651	Trace Amine-associated Receptor (TAAR)	Neurological Disease
ZH8651 is an agonist of TAAR1 which can activate both Gs and Gq signal pathway. ZH8651 can used in study schizophrenia .

HY-114753A

Neboglamine hydrochloride CR-2249 hydrochloride; XY-2401 hydrochloride	iGluR	Neurological Disease
Neboglamine (CR-2249, XY-2401) hydrochloride is an orally active NMDA receptor glycine site positive modulator that can be used in schizophrenia research .

HY-14539S2

Clozapine-d4 HF 1854-d₄	Isotope-Labeled Compounds Dopamine Receptor mAChR Adrenergic Receptor 5-HT Receptor	Neurological Disease
Clozapine-d₄ is the deuterium labeled Clozapine. Clozapine is an antipsychotic used for the research of schizophrenia. Clozapine has high affinity for a number of neuroreceptors .

HY-14538B

Haloperidol lactate 20+ Cited Publications	Dopamine Receptor	Neurological Disease Cancer
Haloperidol lactate is a potent antipsychotic agent. Haloperidol lactate can be used in acute and chronic schizophrenia and gilles de la tourette's syndrome. Haloperidol lactate has the potential for the research of psychotic disorders .

HY-10716A

PF-03463275	GlyT	Neurological Disease
PF-03463275 is a centrally penetrant, orally available, selective, and competitive GlyT1 (glycine transporter-1) reversible inhibitor, with a K_i of 11.6 nM. PF-03463275 has the potential for Schizophrenia research .

HY-14338A

Idalopirdine hydrochloride Lu AE58054 hydrochloride	5-HT Receptor	Neurological Disease
Idalopirdine hydrochloride (Lu AE58054 hydrochloride) is a potent, selective 5-HT6 receptor antagonist with a K_i value of 0.83 nM. Idalopirdine hydrochloride may be used in studies of Alzheimer's disease and schizophrenia, among other related disorders .

HY-117699

Fluanisone	Biochemical Assay Reagents	Neurological Disease
Fluanisone has potent sedative effect in vivo. Fluanisone can be used to study schizophrenia .

HY-G0001A

Lurasidone Metabolite 14283 hydrochloride	Drug Metabolite	Neurological Disease
Lurasidone Metabolite 14283 hydrochloride is a major active metabolite of Lurasidone. Lurasidone is a FDA approved agent for the treatment of schizophrenia.

HY-14539S

Clozapine-d8 HF 1854-d₈	Dopamine Receptor mAChR Adrenergic Receptor 5-HT Receptor	Neurological Disease
Clozapine-d₈ is the deuterium labeled Clozapine. Clozapine is an antipsychotic used for the research of schizophrenia. Clozapine has high affinity for a number of neuroreceptors .

HY-G0003

Iloperidone metabolite Hydroxy Iloperidone P88; Hydroxy Iloperidone	Drug Metabolite	Neurological Disease
Iloperidone metabolite Hydroxy Iloperidone (P88; Hydroxy Iloperidone) is an active reduced metabolite of Iloperidone (HY-17410). Iloperidone metabolite Hydroxy Iloperidone can be used for the research of schizophrenia .

HY-A0151

Thioproperazine 2 Publications Verification RP 7843; SKF 5883; Thioperazine	Dopamine Receptor	Neurological Disease
Thioproperazine (RP 7843) is an orally active antipsychotic agent with calming, antiemetic activity. Thioproperazine is effective in promoting the release of dopamine in rat striatum. Thioproperazine can be used in studies of schizophrenia and bipolar disorder .

HY-105040C

Pomaglumetad methionil hydrochloride LY2140023 hydrochloride	mGluR	Neurological Disease
Pomaglumetad methionil hydrochloride (LY2140023 hydrochloride) is an orally active, methionine prodrug of the selective mGlu2/3 receptor agonist LY404039. Pomaglumetad methionil hydrochloride has the potential for schizophrenia research .

HY-A0163A

Clopenthixol	Dopamine Receptor	Neurological Disease
Clopenthixol is a thiaquinoline compound with inhibitory effects similar to those of phenothiazine antipsychotics. Clopenthixol is an antagonist of D1 and D2 dopamine receptors. Clopenthixol is mainly used to suppress schizophrenia and other mental disorders .

HY-152838

Gemlapodect RO554965	Phosphodiesterase (PDE)	Neurological Disease
Gemlapodect (RO554965) is an inhibitor of phosphodiesterase 10A (PDE10A). Gemlapodect can be used for researching schizophrenia .

HY-B1904A

Fluphenazine decanoate dihydrochloride	Dopamine Receptor	Neurological Disease
Fluphenazine decanoate dihydrochloride is a CNS-penetrant dopamine D₂ receptor inhibitor, is a long-acting phenothiazine neuroleptic. Fluphenazine can be used for schizophrenia research .

HY-107434

Molindone (±)-Molindone; SPN-810M	Dopamine Receptor	Neurological Disease
Molindone ((±)-Molindone), an indole derivative, is a potent dopamine D2 and D5 receptor antagonist. Molindone ((±)-Molindone) can be used for the research of schizophrenia and severe mental illness .

HY-127086A

Dicarbine dihydrochloride	Dopamine Receptor	Neurological Disease
Dicarbine dihydrochloride blocks dopamine receptors in various brain parts and prevents the depression of the conditioned defence reflexes caused by stimulation of the mesencephalic portion of the reticular formation. Dicarbine dihydrochloride could be used in the schizophrenia and alcoholic psychosis studies .

HY-17410S

Iloperidone-d3	Isotope-Labeled Compounds 5-HT Receptor Dopamine Receptor	Neurological Disease
Iloperidone-d₃ is the deuterium labeled Iloperidone. Iloperidone (HP 873) is a D2/5-HT2 receptor antagonist. Iloperidone is an atypical antipsychotic for the schizophrenia symptoms .

HY-110176

ASP2535	GlyT	Neurological Disease
ASP2535 is a potent, orally bioavailable, selective, brain permeable and centrally-active glycine transporter-1 (GlyT1) inhibitor. ASP2535 can improve cognitive impairment in animal models of schizophrenia and Alzheimer's disease .

HY-169742

Epibatidine	nAChR	Neurological Disease
Epibatidine is a α7nACh agonist with a K_d of 100 nM. Epibatidine can be used in the study of Alzheimer's, Parkinson's and schizophrenia .

HY-117046

AVN-101	5-HT Receptor Histamine Receptor Adrenergic Receptor	Neurological Disease
AVN-101 is a potent, brain-penetrant and orally active 5-HT7 receptor antagonist (K_i of 153 pM), with slightly lesser potency toward 5-HT6, 5-HT2A, and 5HT-2C receptors (K_i values of 2.04 nM, 1.56 nM, and 1.17 nM, respectively). AVN-101 also exhibits a rather high affinity toward histamine H1 (K_i of 0.58 nM) and adrenergic α2A, α2B, and α2C (K_i= 0.41-3.6 nM) receptors. AVN-101 can be studied in such diseases as general anxiety disorders, depression, schizophrenia, Alzheimer’s disease, and multiple sclerosis .

HY-14555

S 33138	Dopamine Receptor	Neurological Disease
S33138 is a D3 receptor antagonist. S33138 inhibits addiction in animal models of addiction. S33138 reduces cognitive impairment in rodent and primate models of schizophrenia and Parkinson's disease. S33138 can be used in research on neurological disorders such as schizophrenia and Parkinson's disease .

HY-168977

Inidascamine RL-007; FSV7-007	GABA Receptor	Neurological Disease
Inidascamine is the modulator for cholinergic, glutamatergic, and GABA_B receptor, and can be used for researchs of schizophrenia .

HY-136678A

SB 258741 hydrochloride	5-HT Receptor	Neurological Disease
SB 258741 hydrochloride is a specific 5-HT₇ receptor antagonist and can be used for the research of schizophrenia .

HY-129507

Aplindore fumarate DAB-452 fumarate	Dopamine Receptor	Neurological Disease
Aplindore fumarate (DAB-452 fumarate) is a dopamine D2 receptor partial agonist. Aplindore fumarate could be used in studies of Parkinson's disease and schizophrenia .

HY-105795

Metiapine	Drug Derivative	Neurological Disease
Metiapine is a new antipsychotic agent and Dibenzothiazepine derivative. Metiapine produces a decrease in food consumption. Metiapine can be used in the research of schizophrenia .

HY-17410A

Iloperidone hydrochloride HP 873 hydrochloride	5-HT Receptor Dopamine Receptor	Neurological Disease
Iloperidone hydrochloride (HP 873 hydrochloride) is a D₂/5-HT₂ receptor antagonist. Iloperidone hydrochloride is an atypical antipsychotic for the schizophrenia symptoms .

HY-14551B

(S)-Osanetant (S)-SR142801	Neurotensin Receptor	Neurological Disease
(S)-Osanetant is the S-enantiomer of Osanetant. Osanetant (SR142801) is a selective NK3 receptor antagonist. Osanetant produces anxiolytic- and antidepressant-like effects and is researched for schizophrenia .

HY-106862A

CGS 15873A	Dopamine Receptor	Neurological Disease
CGS 15873A is an orally active benzopyranopyridine derivative. CGS 15873A has selective dopamine receptor activation activity. CGS 15873A can be used for research on schizophrenia or Parkinson's disease .

HY-116916

Acetophenazine 1 Publications Verification	Dopamine Receptor	Neurological Disease
Acetophenazine, a phenothiazine derivative, is an antipsychotic agent. Acetophenazine primarily blocks dopamine D2 receptors in the brain. Acetophenazine can be used for researching psychotic disorders such as schizophrenia and anxious depression .

HY-127120

Timiperone	Dopamine Receptor	Neurological Disease
Timiperone has a strong affinity for cerebral dopamine D2 receptor. Timiperone has antipsychotic activity, and inhibits stereotyped behaviour. Timiperone can be used for research of schizophrenia .

HY-19332R

Kifunensine (Standard) FR-900494 (Standard)	Reference Standards Glycosidase Others	Inflammation/Immunology
Bromperidol decanoate (Standard) is the analytical standard of Bromperidol decanoate. This product is intended for research and analytical applications. Bromperidol decanoate (R46541) is a compound used for the inhibition of schizophrenia and has certain clinical inhibitory activity.

HY-113745

LX-6171	Amino acid Transporter	Neurological Disease
LX-6171 is an orally active SLC6A7 inhibitor. LX-6171 can be used to study diseases characterized by cognitive impairment, such as Alzheimer's disease, schizophrenia or vascular dementia .

HY-168537

LB-102	Dopamine Receptor 5-HT Receptor	Neurological Disease
LB-102 is an orally active inhibitor of dopamine D₂, D₃, and 5-HT7 receptors, which can be used in research on schizophrenia and other psychiatric disorders .

HY-14554

Pomaglumetad methionil anhydrous LY2140023	mGluR	Neurological Disease
Pomaglumetad methionil anhydrous (LY2140023) is an orally active, methionine prodrug of the selective mGlu2/3 receptor agonist LY404039. LY2140023 has the potential for schizophrenia research .

HY-112320

UCSF34	Dopamine Receptor	Neurological Disease
UCSF34 (Compound 54) is a Haloperidol (HY-14538) analogue. UCSF34 binds to the human D₂L receptor, with an estimated pK_i of 7.49. UCSF34 can be used in the research of schizophrenia .

HY-127086

Dicarbine	Dopamine Receptor	Neurological Disease
Dicarbine blocks dopamine receptors in various brain parts and prevents the depression of the conditioned defence reflexes caused by stimulation of the mesencephalic portion of the reticular formation. Dicarbine could be used in the schizophrenia and alcoholic psychosis studies .

Cat. No.	Product Name	Type

HY-65036

4-Bromo-2-hydroxypyridine 4-Bromo-2-pyridone	Biochemical Assay Reagents
4-Bromo-2-hydroxypyridine is an intermediate. 4-Bromo-2-hydroxypyridine can be used to synthesize M₁ muscarinic acetylcholine receptor (M₁ mAChR) positive allosteric modulators. 4-Bromo-2-hydroxypyridine can be used in the research of Alzheimer's disease and schizophrenia .

HY-15401A

WAY 163909 (hydrochloride)

Biochemical Assay Reagents

WAY 163909 hydrochloride is an orally active, blood-brain barrier permeable 5-HT2C receptor-selective agonist. WAY 163909 hydrochloride exhibits an EC₅₀ of 8 nM and a K_i of 10.5 nM for h5-HT2C. Instead of triggering apoptosis, WAY 163909 hydrochloride induces anorectic, antipsychotic-like, antidepressant-like, anti-aggressive and anti-compulsive effects. WAY 163909 hydrochloride alleviates ketamine-induced hypothermia, but impairs sexual function at high doses. With rapid antidepressant-like properties, WAY 163909 hydrochloride can be used in research related to obesity, schizophrenia, depression, obsessive-compulsive disorder, and anesthesia-induced hypothermia .

Cat. No.	Product Name	Target	Research Area

HY-P6292A

KS-133 TFA	PACAP Receptor	Neurological Disease Inflammation/Immunology Cancer
KS-133 TFA is a highly selective and potent antagonist of the vascular active enteropeptide receptor 2 (VIPR2) with IC₅₀ values for Ca influx measurement and cAMP measurement of 24.8 nM and 500 nM, respectively. KS-133 TFA reverses the tumor-promoting M2 phenotype of tumor-associated macrophages to the anti-tumor M1 phenotype, alters the tumor immune microenvironment, and inhibits tumor growth. KS-133 TFA can be used for research on schizophrenia and cancer immune regulation .

HY-P6292

KS-133	PACAP Receptor PKA ERK PI3K Akt GSK-3	Neurological Disease Cancer
KS-133 is a bicyclic peptide with VIPR2 antagonistic activity that can cross the blood-brain barrier. KS-133 selectively blocks VIPR2-mediated Gq/Ca, Gs/cAMP, cAMP/PKA/ERK and PI3K/AKT/GSK3β signaling pathways. KS-133 inhibits VIPR2 agonist-induced CREB phosphorylation in the prefrontal cortex of mice. KS-133 shifts the polarization direction of macrophages toward M1. KS-133 attenuates cancer cell proliferation and reduces the cell cycle distribution level at the S-M phase. KS-133 exerts antitumor effects in a mouse model of colorectal cancer. KS-133 reverses cognitive decline in mouse models of psychiatric disorders. KS-133 can be used for research related to schizophrenia, colorectal cancer and breast cancer .

HY-U00372

2: PN: US20040072744 SEQID: 2 claimed protein	Peptides	Neurological Disease
2: PN: US20040072744 SEQID: 2 claimed protein is a synthetic peptide, used for the research of Down's syndrome and schizophrenia.

HY-P5857

MmTx2 toxin Micrurotoxin 2	GABA Receptor	Neurological Disease
MmTx2 toxin is a GABA_A receptor modulator that enhances GABA_A receptor sensitivity to agonists. MmTx2 toxin can be obtained from venom of coral snake. MmTx2 toxin can be used in the study of neurological diseases such as epilepsy, schizophrenia and chronic pain .

Cat. No.	Product Name	Target	Research Area	Image

HY-P992360

GT-002	GABA Receptor	Neurological Disease Cancer
GT-002 is a partial positive allosteric modulator targeting the α3 subtype of GABAA receptors, as well as a specific binder of tumor-associated TF-glycosylated LYPD3. GT-002 mildly enhances GABA-induced chloride currents by binding to the benzodiazepine site of GABAA receptors, thereby alleviating prefrontal hypofunction and improving cognitive, memory and social interaction abilities. GT-002 can be used in research related to schizophrenia spectrum disorders, various squamous cell carcinomas, colorectal cancer, non-small cell lung cancer, and aromatic L-amino acid decarboxylase deficiency .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-101037

Sarcosine 3 Publications Verification N-Methylglycine; Sarcosin	Human Gut Microbiota Metabolites Immune System Disorder Microorganisms Classification of Application Fields Disease markers Endocrine diseases Amino acids Endogenous metabolite Disease Research Fields Source Classification Cancer	Endogenous Metabolite GlyT
Sarcosine (N-Methylglycine), an endogenous amino acid, is a competitive glycine transporter type I (GlyT1) inhibitor and N-methyl-D-aspartate (NMDA) receptor co-agonist. Sarcosine increases the glycine concentration, resulting in an indirect potentiation of the NMDA receptor. Sarcosine is commonly used for the research of schizophrenia .

HY-A0019

Paliperidone 3 Publications Verification 9-Hydroxyrisperidone	Natural Products Endogenous metabolite Source Classification	Drug Metabolite Dopamine Receptor 5-HT Receptor Adrenergic Receptor
Paliperidone (9-Hydroxyrisperidone), the major active metabolite of Risperidone, is a dopamine D2 antagonist and 5-HT2A antagonist. Paliperidone is also active as an antagonist at α1 and α2 adrenergic receptors and H1-histaminergic receptors. Paliperidone, a antipsychotic agent, shows efficacy against schizophrenia .

HY-I1070

D-Isoleucine (R)-Isoleucine	Microorganisms Source Classification	ASCT
D-Isoleucine is a selective competitive activator of the Asc-1 antiporter (Ki=0.98 mM). D-Isoleucine promotes the release of D-serine and glycine by binding to the Asc-1 protein on the neuronal cell membrane, and enhances NMDA receptor-dependent synaptic plasticity. D-Isoleucine can be used in the study of neurodegenerative diseases (such as Alzheimer's disease and schizophrenia). D-Isoleucine also acts as a non-classical D-amino acid, interferes with bacterial peptidoglycan synthesis, and inhibits the formation of Staphylococcus aureus biofilm, and has potential antibacterial application value[1][2].

HY-W002112

(±)-Nornicotine Nornicotine	Structural Classification Alkaloids Pyrrole Alkaloids Neurological Disease Classification of Application Fields Pyridine Alkaloids Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite Drug Metabolite nAChR β-catenin
(±)-Nornicotine is a major metabolite of Nicotine. (±)-Nornicotine is a partial nAChRs agonist, specifically activating receptor subtypes containing α7 and α6 subunits. (±)-Nornicotine disrupts β-catenin and ZO-1, and induces F-actin depolymerization. (±)-Nornicotine supports self-administration behavior. (±)-Nornicotine can be used in the research of atherosclerosis, Alzheimer's disease, and schizophrenia .

HY-W001160

5-Hydroxyindole	Alkaloids Monophenols Classification of Application Fields Other Diseases Phenols Endogenous metabolite Disease Research Fields Indole Alkaloids Source Classification	Endogenous Metabolite Calcium Channel nAChR
5-Hydroxyindole is an orally active hydroxylated indole and tryptophan metabolite. 5-Hydroxyindole activates α7 nicotinic acetylcholine receptors and acts on intestinal L-type calcium channels. 5-Hydroxyindole slows down the desensitization of 5-HT₃ receptor-mediated ion currents in cells. 5-Hydroxyindole causes convulsions and loss of consciousness. 5-Hydroxyindole is used in the study of neuroblastoma, schizophrenia, and diseases related to intestinal motility disorders .

HY-B2167R

Docosahexaenoic acid (Standard) DHA (Standard); Cervonic acid (Standard)	Structural Classification Human Gut Microbiota Metabolites Microorganisms Ketones, Aldehydes, Acids Disease markers Endogenous metabolite Cardiovascular System Disorder Source Classification	Reference Standards Endogenous Metabolite
Docosahexaenoic acid (Standard) is the analytical standard of Docosahexaenoic acid. This product is intended for research and analytical applications. Docosahexaenoic Acid (DHA) is an omega-3 fatty acid abundantly present brain and retina. It can be obtained directly from fish oil and maternal milk. In Vitro: Docosahexaenoic acid (DHA) is essential for the growth and functional development of the brain in infants. DHA is also required for maintenance of normal brain function in adults. The inclusion of plentiful DHA in the diet improves learning ability and memory . DHA is an essential requirement in every step of brain development like neural cell proliferation, migration, differentiation, synaptogenesis. The multiple double bonds and unique structure allow DHA to impart special membrane characteristics for effective cell signaling. Many development disorders like dyslexia, autism spectrum disorder, attention deficit hyperactivity disorder, schizophrenia etc. are causally related to decreased level of DHA . DHA is a potent RXR ligand inducing robust RXR activation already at low micro molar concentrations. The EC₅₀ for RXRα activation by DHA is about 5-10 μM fatty acid . In Vivo: Docosahexaenoic acid administration over 10 weeks significantly reduces the number of reference memory errors, without affecting the number of working memory errors, and significantly increases the docosahexaenoic acid content and the docosahexaenoic acid/arachidonic acid ratio in both the hippocampus and the cerebral cortex . DHA treatment exerts neuroprotective actions on an experimental mouse model of PD. There is a decrease tendency in brain lipid oxidation of MPTP mice but it does not significantly .

HY-113323

3-Methoxy-4-hydroxyphenylglycol 2 Publications Verification HMPG; MHPG; MOPEG	Monophenols Neurological Disease Classification of Application Fields Phenols Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
3-Methoxy-4-hydroxyphenylglycol (HMPG) is a metabolite of norepinephrine degradation in the brain. 3-Methoxy-4-hydroxyphenylglycol is an indicators of central nervous system noradrenergic activity. 3-Methoxy-4-hydroxyphenylglycol can be used for research of depression, chronic schizophrenia, etc .

HY-W012922

2-Methyl-4-pentenoic Acid 2-Methylpent-4-enoic acid	Structural Classification other families Classification of Application Fields Ketones, Aldehydes, Acids Other Diseases Plants Disease Research Fields Source Classification	Drug Intermediate
2-Methyl-4-pentenoic Acid (2-Methylpent-4-enoic acid) is an organic acid that can be used as a precursor for synthesizing other compounds. Additionally, changes in the level of 2-Methyl-4-pentenoic Acid may be associated with the susceptibility to schizophrenia and type 2 diabetes .

HY-W009390

DL-Homocystine	Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
DL-Homocystine is the double-bonded form of homocysteine and homocysteine is recognized as an important substance in the pathogenesis and pathophysiology of schizophrenia.

HY-N2125

Parishin C	Structural Classification Gastrodia elata Bl. Orchidaceae Phenols Plants Source Classification	5-HT Receptor iGluR Caspase Interleukin Related TNF Receptor SOD NF-κB
Parishin C is a brain-penetrant major bioactive component found in Gastrodia elata Blume. Parishin C is a 5-HT1A receptor agonist with an EC₅₀ of 34 nM. Parishin C has antipsychotic and neuroprotective effects. Parishin C protects against Aβ-induced long-term potentiation damage and NMDA receptor current impairment. Parishin C reduces oxidative stress, pro-inflammatory cytokine levels, caspase activity, brain water content, and cerebral infarct volume; increases antioxidant enzyme activity and BDNF levels; improves nerve function and histopathological brain damage. Parishin C attenuates phencyclidine-induced immobility time increases, sociability deficits, and visual recognition memory impairment. Parishin C can be used for the research of ischemic stroke, Alzheimer's disease, and schizophrenia-like psychosis .

HY-101037R

Sarcosine (Standard) N-Methylglycine (Standard); Sarcosin (Standard)	Structural Classification Human Gut Microbiota Metabolites Immune System Disorder Microorganisms Disease markers Endocrine diseases Amino acids Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite GlyT
Sarcosine (Standard) is the analytical standard of Sarcosine. This product is intended for research and analytical applications. Sarcosine (N-Methylglycine), an endogenous amino acid, is a competitive glycine transporter type I (GlyT1) inhibitor and N-methyl-D-aspartate (NMDA) receptor co-agonist. Sarcosine increases the glycine concentration, resulting in an indirect potentiation of the NMDA receptor. Sarcosine is commonly used for the research of schizophrenia .

HY-19332R

Kifunensine (Standard) FR-900494 (Standard)	Alkaloids Piperidine Alkaloids Microorganisms Source Classification	Reference Standards Glycosidase Others
Bromperidol decanoate (Standard) is the analytical standard of Bromperidol decanoate. This product is intended for research and analytical applications. Bromperidol decanoate (R46541) is a compound used for the inhibition of schizophrenia and has certain clinical inhibitory activity.

HY-139568

Deutarserine CTP-692	Neurological Disease Classification of Application Fields Amino acids Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
Deutarserine is a deuterium modified analog of endogenous D-serine (CTP 692), which is used in the research of adults with schizophrenia .

HY-B1131R

Taurocholic acid sodium salt hydrate (Standard) Sodium taurocholate hydrate (Standard); N-Choloyltaurine sodium salt hydrate (Standard)	Structural Classification Endogenous metabolite Steroids Source Classification	Reference Standards Endogenous Metabolite
Zuclopenthixol (dihydrochloride) (Standard) is the analytical standard of Zuclopenthixol (dihydrochloride). This product is intended for research and analytical applications. Zuclopenthixol ((Z)-Clopenthixol) dihydrochloride is a thioxanthene derivative which acts as a mixed dopamine D1/D2 receptor antagonist. Zuclopenthixol dihydrochloride is used in the study of schizophrenia .

HY-A0019R

Paliperidone (Standard) 9-Hydroxyrisperidone (Standard)	Structural Classification Natural Products Endogenous metabolite Source Classification	Drug Metabolite Reference Standards Dopamine Receptor 5-HT Receptor Adrenergic Receptor
Paliperidone (Standard) is the analytical standard of Paliperidone. This product is intended for research and analytical applications. Paliperidone (9-Hydroxyrisperidone), the major active metabolite of Risperidone, is a dopamine D2 antagonist and 5-HT2A antagonist. Paliperidone is also active as an antagonist at α1 and α2 adrenergic receptors and H1-histaminergic receptors. Paliperidone, a antipsychotic agent, shows efficacy against schizophrenia .

HY-W002112R

(±)-Nornicotine (Standard) Nornicotine (Standard)	Structural Classification Alkaloids Pyrrole Alkaloids Pyridine Alkaloids Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite Drug Metabolite nAChR β-catenin
(±)-Nornicotine (Standard) is the analytical standard of (±)-Nornicotine (HY-W002112). This product is intended for research and analytical applications. (±)-Nornicotine is a major metabolite of Nicotine. (±)-Nornicotine is a partial nAChRs agonist, specifically activating receptor subtypes containing α7 and α6 subunits. (±)-Nornicotine disrupts β-catenin and ZO-1, and induces F-actin depolymerization. (±)-Nornicotine supports self-administration behavior. (±)-Nornicotine can be used in the research of atherosclerosis, Alzheimer's disease, and schizophrenia .

HY-W012922R

2-Methyl-4-pentenoic Acid (Standard) 2-Methylpent-4-enoic acid (Standard)	Structural Classification other families Ketones, Aldehydes, Acids Plants Source Classification	Reference Standards Drug Intermediate
2-Methyl-4-pentenoic Acid (Standard) (2-Methylpent-4-enoic acid (Standard)) is the analytical standard of 2-Methyl-4-pentenoic Acid (HY-W012922). This product is intended for research and analytical applications. 2-Methyl-4-pentenoic Acid (2-Methylpent-4-enoic acid) is an organic acid that can be used as a precursor for synthesizing other compounds. Additionally, changes in the level of 2-Methyl-4-pentenoic Acid may be associated with the susceptibility to schizophrenia and type 2 diabetes.

HY-W001160R

5-Hydroxyindole (Standard)	Alkaloids Structural Classification Monophenols Phenols Endogenous metabolite Indole Alkaloids Source Classification	Reference Standards Endogenous Metabolite nAChR Calcium Channel
5-Hydroxyindole (Standard) is the analytical standard of 5-Hydroxyindole (HY-W001160). This product is intended for research and analytical applications. 5-Hydroxyindole is an orally active hydroxylated indole and tryptophan metabolite. 5-Hydroxyindole activates α7 nicotinic acetylcholine receptors and acts on intestinal L-type calcium channels. 5-Hydroxyindole slows down the desensitization of 5-HT₃ receptor-mediated ion currents in cells. 5-Hydroxyindole causes convulsions and loss of consciousness. 5-Hydroxyindole is used in the study of neuroblastoma, schizophrenia, and diseases related to intestinal motility disorders .

HY-N2125R

Parishin C (Standard)	Structural Classification Gastrodia elata Bl. Orchidaceae Phenols Plants Source Classification	Reference Standards 5-HT Receptor iGluR Caspase Interleukin Related TNF Receptor SOD NF-κB
Parishin C (Standard) is the analytical standard of Parishin C (HY-N2125). This product is intended for research and analytical applications. Parishin C is a brain-penetrant major bioactive component found in Gastrodia elata Blume. Parishin C is a 5-HT1A receptor agonist with an EC₅₀ of 34 nM. Parishin C has antipsychotic and neuroprotective effects. Parishin C protects against Aβ-induced long-term potentiation damage and NMDA receptor current impairment. Parishin C reduces oxidative stress, pro-inflammatory cytokine levels, caspase activity, brain water content, and cerebral infarct volume; increases antioxidant enzyme activity and BDNF levels; improves nerve function and histopathological brain damage. Parishin C attenuates phencyclidine-induced immobility time increases, sociability deficits, and visual recognition memory impairment. Parishin C can be used for the research of ischemic stroke, Alzheimer's disease, and schizophrenia-like psychosis .

HY-W041470R

4-Methyl-1-phenyl-2-pentanone (Standard)	Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite
Chlorpromazine (hydrochloride) (Standard) is the analytical standard of Chlorpromazine (hydrochloride). This product is intended for research and analytical applications. Chlorpromazine hydrochloride is an orally active, blood-brain barrier-transparent antipsychotic agent that effectively antagonises D2 dopamine receptors and 5-HT2A, which is widely used in schizophrenia and other psychiatric disorders. Chlorpromazine hydrochloride exerts anti-cancer activity through a variety of pathways, including anti-proliferation, induction of autophagy and cycle arrest (G2-M phase), inhibition of cytochrome c oxidase (CcO), inhibition of tumour growth and metastasis, and inhibition of tumour immune escape. Chlorpromazine hydrochloride also blocks hNav1.7 channels (IC50=25.9 μM; concentration-dependent) and HERG potassium channels (IC50=21.6 μM), which has potential for analgesic and cardiac arrhythmic studies. Chlorpromazine hydrochloride also can inhibit clathrin-mediated endocytosis .

HY-180718

Beta-alanyl-L-arginine β-Alanyl-L-arginine	Structural Classification Amino acids Endogenous metabolite Source Classification	Nucleoside Antimetabolite/Analog
Beta-alanyl-L-arginine (β-Alanyl-L-arginine) is an intestinal microbial metabolite. Beta-alanyl-L-arginine can be used for the study of schizophrenia .

Cat. No.	Product Name	Chemical Structure

HY-101037S1

Sarcosine-d3
Sarcosine-d₃ is the deuterium labeled Sarcosine. Sarcosine (N-Methylglycine), an endogenous amino acid, is a competitive glycine transporter type I (GlyT1) inhibitor and N-methyl-D-aspartate (NMDA) receptor co-agonist. Sarcosine increases the glycine concentration, resulting in an indirect potentiation of the NMDA receptor. Sarcosine is commonly used for the research of schizophrenia .

HY-14539S2

Clozapine-d4
Clozapine-d₄ is the deuterium labeled Clozapine. Clozapine is an antipsychotic used for the research of schizophrenia. Clozapine has high affinity for a number of neuroreceptors .

HY-14539S

Clozapine-d8
Clozapine-d₈ is the deuterium labeled Clozapine. Clozapine is an antipsychotic used for the research of schizophrenia. Clozapine has high affinity for a number of neuroreceptors .

HY-113323S

3-Methoxy-4-hydroxyphenylglycol-d3

3-Methoxy-4-hydroxyphenylglycol-d₃ (HMPG-d₃) is the deuterium labeled 3-Methoxy-4-hydroxyphenylglycol. 3-Methoxy-4-hydroxyphenylglycol is a metabolite of norepinephrine degradation in the brain. 3-Methoxy-4-hydroxyphenylglycol (HMPG) serves as an indicator of noradrenergic activity in the central nervous system. 3-Methoxy-4-hydroxyphenylglycol (HMPG) can be used for research on diseases such as depression and chronic schizophrenia.

HY-105182S1

Xanomeline-d3
Xanomeline-d₃ (LY-246708-d₃) is deuterium labeled Xanomeline. Xanomeline, as an effective and selective muscarinic type 1 and type 4 (M1/M4) receptor agonist, increases neuronal excitability. Xanomeline can be used for the research of neurological disorders, such as schizophrenia .

HY-101037S

Sarcosine-15N
Sarcosine- ¹⁵N is the ¹⁵N-labeled Sarcosine. Sarcosine (N-Methylglycine), an endogenous amino acid, is a competitive glycine transporter type I (GlyT1) inhibitor and N-methyl-D-aspartate (NMDA) receptor co-agonist. Sarcosine increases the glycine concentration, resulting in an indirect potentiation of the NMDA receptor. Sarcosine is commonly used for the research of schizophrenia .

HY-W002112S

(±)-Nornicotine-d4

(±)-Nornicotine-d₄ is the deuterium labeled (±)-Nornicotine (HY-W002112). (±)-Nornicotine is a major metabolite of Nicotine. (±)-Nornicotine is a partial nAChRs agonist, specifically activating receptor subtypes containing α7 and α6 subunits. (±)-Nornicotine disrupts β-catenin and ZO-1, and induces F-actin depolymerization. (±)-Nornicotine supports self-administration behavior. (±)-Nornicotine can be used in the research of atherosclerosis, Alzheimer's disease, and schizophrenia .

HY-17410S

Iloperidone-d3
Iloperidone-d₃ is the deuterium labeled Iloperidone. Iloperidone (HP 873) is a D2/5-HT2 receptor antagonist. Iloperidone is an atypical antipsychotic for the schizophrenia symptoms .

HY-W009390S

DL-Homocystine-3,3,3’,3’,4,4,4’,4’-d8
DL-Homocystine-3,3,3’,3’,4,4,4’,4’-d₈ is the deuterium labeled DL-Homocystine. DL-Homocystine is the double-bonded form of homocysteine and homocysteine is recognized as an important substance in the pathogenesis and pathophysiology of schizophrenia .

HY-A0019S

Paliperidone-d4
Paliperidone-d₄ is the deuterium labeled Paliperidone. Paliperidone (9-Hydroxyrisperidone), the major active metabolite of Risperidone, is a dopamine D2 antagonist and 5-HT2A antagonist. Paliperidone is also active as an antagonist at α1 and α2 adrenergic receptors and H1-histaminergic receptors. Paliperidone, a antipsychotic agent, shows efficacy against schizophrenia .

HY-14546S

Aripiprazole-d8

Aripiprazole-d₈ (OPC-14597-d₈) is the deuterium labeled Aripiprazole (HY-14546). Aripiprazole (OPC-14597), an atypical antipsychotic, is a potent and high-affinity dopamine D2 receptor partial agonist. Aripiprazole is an inverse agonist at 5-HT2B and 5-HT2A receptors and displays partial agonist actions at 5-HT1A, 5-HT2C, D3, and D4 receptors. Aripiprazole can be used for the research of schizophrenia and COVID19.

HY-W748519

Sarcosine-13C3

Sarcosine- ¹³C₃ (N-Methylglycine- ¹³C₃; Sarcosin- ¹³C₃) is the ¹³C-labeled Sarcosine (HY-101037). Sarcosine (N-Methylglycine), an endogenous amino acid, is a competitive glycine transporter type I (GlyT1) inhibitor and N-methyl-D-aspartate (NMDA) receptor co-agonist. Sarcosine increases the glycine concentration, resulting in an indirect potentiation of the NMDA receptor. Sarcosine is commonly used for the research of schizophrenia .

HY-17637S2

Lumateperone-d4

Lumateperone-d₄ (ITI-007-d₄) is deuterium labeled Lumateperone. Lumateperone (ITI-007) is an orally active 5-HT2A receptor antagonist (Ki = 0.54 nM), a partial agonist of presynaptic D2 receptors and an antagonist of postsynaptic D2 receptors (Ki = 32 nM), and a dopamine D1 receptor modulator. Lumateperone has anticancer activity and can also be used for the study of schizophrenia and bipolar depression .

HY-A0019AS

Paliperidone palmitate-d4

Paliperidone palmitate-d₄ (9-Hydroxyrisperidone palmitate-d₄) is the deuterium labeled Paliperidone palmitate (HY-A0019A). Paliperidone palmitate is an orally effective competitive antagonist of dopamine D2 receptors and 5-hydroxytryptamine 2A (5-HT2A) receptors that can cross the blood-brain barrier. Paliperidone palmitate competitively inhibits the effects of dopamine and 5-hydroxytryptamine by binding to dopamine D2 receptors and 5-HT2A receptors, regulating the balance of the neurotransmitter system and thus exerting antipsychotic activity. Paliperidone palmitate is mainly used in the research field of schizophrenia .

HY-B2169S2

Melperone-d4 hydrochloride

Melperone-d₄ hydrochloride is the deuterium labeled Melperone hydrochloride (HY-103109) . Melperone hydrochloride is a butyrophenone with atypical antipsychotic properties. Melperone hydrochloride is a multireceptor antagonist with K_ds of 102 nM, 180 nM, 180 nM, and 150 nM for 5-HT2A, dopamine D2, α1-adrenergic, and α2-adrenergic receptors, respectively. Melperone hydrochloride has weak binding to histamine H1, 5-HT2C, 5-HT1A, 5-HT1D, and muscarinic receptors, with K_d values of 580 nM, 2100 nM, 2200 nM, 3400 nM, >10000 nM, respectively. Melperone hydrochloride is also a CYP2D6 inhibitor. Melperone hydrochloride can be used for the study of schizophrenia, and agitation in the elderly .

HY-107434S

Molindone-d8
Molindone-d₈ is the deuterium labeled Molindone. Molindone hydrochloride (EN-1733A) is a therapeutic antipsychotic, used in the treatment of schizophrenia, works by blocking the effects of dopamine in the brain, leading to diminished psychoses .

HY-17410S1

Iloperidone-d3 hydrochloride
Iloperidone-d₃ hydrochloride is deuterated labeled Iloperidone (HY-17410). Iloperidone (HP 873) is a D₂/5-HT₂ receptor antagonist. Iloperidone is an atypical antipsychotic for the schizophrenia symptoms .

HY-10933S

CX516-d10
CX516-d₁₀ is the deuterium labeled CX516. CX516 (BDP 12) is an ampakine and acts as an AMPA receptor positive allosteric modulator for the research of Alzheimer's disease, schizophrenia and mild cognitive impairment (MCI) .

HY-17410S2

Iloperidone-13C,d3
Iloperidone- ¹³C,d₃ (HP 873- ¹³C,d₃) is ¹³C labeled Iloperidone. Iloperidone (HP 873) is a D₂/5-HT₂ receptor antagonist. Iloperidone is an atypical antipsychotic for the schizophrenia symptoms .

HY-G0003S1

Iloperidone metabolite Hydroxy Iloperidone-d3
Iloperidone metabolite Hydroxy Iloperidone-d₃ is the deuterium labeled Iloperidone metabolite Hydroxy Iloperidone (HY-G0003). Iloperidone metabolite Hydroxy Iloperidone (P88; Hydroxy Iloperidone) is an active reduced metabolite of Iloperidone (HY-17410). Iloperidone metabolite Hydroxy Iloperidone can be used for the research of schizophrenia .

HY-W741434

Acetophenazine dimaleate-d4
Acetophenazine dimaleate-d₄ is the deuterium labeled Acetophenazine (dimaleate) (HY-B1262). Acetophenazine dimaleate, a phenothiazine derivative, is an antipsychotic agent. Acetophenazine dimaleate primarily blocks dopamine D2 receptors in the brain. Acetophenazine dimaleate can be used for researching psychotic disorders such as schizophrenia and anxious depression .

HY-10121S2

Asenapine-13C,d3

Asenapine- ¹³C,d₃ is ¹³C and deuterated labeled Asenapine (HY-10121). Asenapine (Org 5222), an atypical antipsychotic, is an antagonist of serotonin receptors (pK_i: 8.4-10.5), adrenoceptors (pK_i: 8.9-9.5), dopamine receptors (pK_i: 8.9-9.4) and histamine receptors (pK_i: 8.2-9.0). Asenapine can be used in the research of schizophrenia and bipolar disorder .

HY-W769200

Asenapine-13C,d3 maleate

Asenapine- ¹³C,d₃ Maleate is the deuterium labeled and ¹³C-Asenapine Maleate (HY-11100). Asenapine (Org 5222) Maleate, an atypical antipsychotic, is an antagonist of serotonin receptors (pK_i: 8.4-10.5), adrenoceptors (pK_i: 8.9-9.5), dopamine receptors (pK_i: 8.9-9.4) and histamine receptors (pK_i: 8.2-9.0). Asenapine Maleate can be used in the research of schizophrenia and bipolar disorder .

HY-B0532AS

Trifluoperazine-d3 dihydrochloride

Trifluoperazine-d₃ (dihydrochloride) is deuterium labeled Trifluoperazine (dihydrochloride). Trifluoperazine dihydrochloride, an antipsychotic agent, acts by blocking central dopamine receptors. Trifluoperazine dihydrochloride is a potent α1-adrenergic receptor antagonist. Trifluoperazine dihydrochloride is a potent NUPR1 inhibitor exerting anticancer activity. Trifluoperazine dihydrochloride is a calmodulin inhibitor, and also inhibits P-glycoprotein. Trifluoperazine dihydrochloride can be used for the research of schizophrenia. Trifluoperazine dihydrochloride acts as a reversible inhibitor of influenza virus morphogenesis .

HY-10121S4

Asenapine-d3,13C

Asenapine-d₃, ¹³C (Org 5222-d₃, ¹³C) is deuterium and ¹³C labeled Asenapine. Asenapine (Org 5222), an atypical antipsychotic, is an antagonist of serotonin receptors (pK_i: 8.4-10.5), adrenoceptors (pK_i: 8.9-9.5), dopamine receptors (pK_i: 8.9-9.4) and histamine receptors (pK_i: 8.2-9.0). Asenapine can be used in the research of schizophrenia and bipolar disorder .

HY-W002112S1

(±)-Nornicotine-d7

(±)-Nornicotine-d₇ is the deuterium labeled (±)-Nornicotine (HY-W002112). (±)-Nornicotine is a major metabolite of Nicotine. (±)-Nornicotine is a partial nAChRs agonist, specifically activating receptor subtypes containing α7 and α6 subunits. (±)-Nornicotine disrupts β-catenin and ZO-1, and induces F-actin depolymerization. (±)-Nornicotine supports self-administration behavior. (±)-Nornicotine can be used in the research of atherosclerosis, Alzheimer's disease, and schizophrenia .

HY-19733S

Lumateperone-13C,d3 tosylate

Lumateperone- ¹³C,d₃ (ITI-007- ¹³C,d₃) tosylate is ¹³C and deuterium labeled Lumateperone (tosylate). Lumateperone (ITI-007) tosylate is a 5-HT2A receptor antagonist (Ki = 0.54 nM), a partial agonist of presynaptic D2 receptors and an antagonist of postsynaptic D2 receptors (Ki = 32 nM), and a dopamine D1 receptor modulator. Lumateperone tosylate has anticancer activity and can also be used in studies of psychiatric disorders such as schizophrenia .

HY-B1482AS

Mesoridazine-d3

Mesoridazine-d₃ is the deuterium labeled Mesoridazine (HY-B1482A). Mesoridazine (TPS-23) , a metabolite of Thioridazine (HY-B0965A), acts as an orally active phenothiazine antipsychotic agent. Mesoridazine is a potent and rapid open-channel blocker of human ether-a-go-go related gene (hERG) channels and blocks hERG currents with an IC₅₀ of 550 nM (at 0 mV) in human embryonic kidney 293 cells .Mesoridazine can be used for the research of schizophrenia, as well as certain other psychiatric disorders .

HY-14539S3

Clozapine-d3

Clozapine-d₃ (HF 1854-d₃) is deuterium labeled Clozapine. Clozapine (HF 1854) is an antipsychotic used for the research of schizophrenia. Clozapine has high affinity for a number of neuroreceptors. Clozapine is a potent antagonist of dopamine D2 with a K_i of 75 nM. Clozapine inhibits the muscarinic M1 receptor and serotonin 5HT2A receptor with K_is of 9.5 nM and 4 nM, respectively . Clozapine is also a potent and selective agonist at the muscarinic M4 receptor (EC₅₀=11 nM) .

HY-110168S

NS 9283-d4
NS 9283-d₄ is the deuterium labeled NS 9283 (HY-110168). NS 9283 is a positive positive allosteric modulator of (α4)₃(β2)₂ nicotinic ACh receptors. NS 9283 can be used in a series of neurological conditions such as attention deficit hyperactivity disorder (ADHD), schizophrenia, Parkinson's disease and Alzheimer's disease .

HY-100656AS

Desmethyl cariprazine-d8

Desmethyl cariprazine-d₈ is the deuterium labeled Desmethyl cariprazine (HY-100656). Desmethyl cariprazine is a major active metabolite of cariprazine, with activities at human dopamine receptors and serotonin receptors, showing a pEC₅₀ of 8.90 at human D2 receptors, a pEC₅₀ of 8.09 at D3 receptors, and a pEC₅₀ of 6.28 at 5-HT1A receptors. Desmethyl cariprazine inhibits forskolin-induced cAMP production at D2, D3 and 5-HT1A receptors, and suppresses serotonin-induced Ca ²⁺ release at 5-HT2B receptors. Desmethyl cariprazine is applicable to research related to schizophrenia, bipolar disorder type I and bipolar disorder.

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