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Cat. No.: HY-120022

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THPP-2

THPP-2 is a tetrahydropyridopyrimidine-type phosphodiesterase 10A (PDE10A) inhibitor with a K_i of 94 nM. THPP-2 is applicable to the research of schizophrenia.

For research use only. We do not sell to patients.

CAS No.: 1393750-01-0
Formula: C₂₇H₂₇N₇O
Molecular Weight:465.56

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

THPP-2 Chemical Structure

CAS No.: 1393750-01-0

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References
Calculators
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Classifications
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Biological Activity

Description

THPP-2 is a tetrahydropyridopyrimidine-type phosphodiesterase 10A (PDE10A) inhibitor with a K_i of 94 nM. THPP-2 is applicable to the research of schizophrenia^[1].

IC₅₀ & Target^[1]

PDE10A

94 nM (Ki)

All Phosphodiesterase (PDE) Isoforms :

Chemical Information

CAS No. 1393750-01-0
Molecular Weight 465.56
Formula C₂₇H₂₇N₇O
SMILES

O=C(NC=1C=CC=CC1)N2CC=3C(=NC(=NC3CC2)C=4C=CN=CC4)N(C)CCC5=NC=CC=C5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Raheem IT, et al. Discovery of tetrahydropyridopyrimidine phosphodiesterase 10A inhibitors for the treatment of schizophrenia. Bioorg Med Chem Lett. 2012;22(18):5903-5908. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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THPP-2

All Phosphodiesterase (PDE) Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

THPP-2 Related Classifications

HY-120022 Related Classifications