Iloperidone hydrochloride
Based on 2 publication(s) in Google Scholar
Iloperidone hydrochloride (HP 873 hydrochloride) is a D2/5-HT2 receptor antagonist. Iloperidone hydrochloride is an atypical antipsychotic for the schizophrenia symptoms.
For research use only. We do not sell to patients.
- CAS No.: 1299470-39-5
- Formula: C24H28ClFN2O4
- Molecular Weight:462.94
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Iloperidone hydrochloride
MoreAll 5-HT Receptor Isoforms
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Biological Activity
Description
IC50 & Target
[1]|
Rat D2 Receptor 54 nM (Ki) |
Rat 5-HT2 Receptor 3.1 nM (Ki) |
Rat D1 Receptor 546 nM (Ki) |
Rat 5-HT1A Receptor 168 nM (Ki) |
Rat 5-HT6 Receptor 42.7 nM (Ki) |
Rat 5-HT7 Receptor 21.6 nM (Ki) |
Human D1 Receptor 216 nM (Ki) |
Human D3 Receptor 7.1 nM (Ki) |
Human D4 Receptor 25 nM (Ki) |
Human D5 Receptor 319 nM (Ki) |
Human 5-HT2A Receptor 5.6 nM (Ki) |
Human 5-HT2C Receptor 42.8 nM (Ki) |
In Vitro
Iloperidone hydrochloride displays higher affinity for the dopamine D3 receptor (Ki=7.1 nM) than for the dopamine D4 receptor (Ki=25 nM). Iloperidone displays high affinity for the 5-HT6 and 5-HT7 receptors (Ki=42.7 and 21.6 nM, respectively), and is found to have higher affinity for the 5-HT2A (Ki=5.6 nM) than for the 5-HT2C receptor (Ki=42.8 nM)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 1299470-39-5
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Molecular Weight 462.94
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Formula C24H28ClFN2O4
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SMILES
CC(C1=CC=C(OCCCN2CCC(C3=NOC4=C3C=CC(F)=C4)CC2)C(OC)=C1)=O.Cl
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Synonyms
HP 873 hydrochloride
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (2)
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Journal Impact Factor
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Most Recent
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Neuroreport
2021 Nov 2;32(16):1299-1306. PMID: 34605450
Purity & Documentation
References
[1]. Kongsamut, S., et al., Iloperidone binding to human and rat dopamine and 5-HT receptors. Eur J Pharmacol, 1996. 317(2-3): p. 417-23. [Content Brief]
[2]. Sainati, S.M., et al., Safety, tolerability, and effect of food on the pharmacokinetics of iloperidone (HP 873), a potential atypical antipsychotic. J Clin Pharmacol, 1995. 35(7): p. 713-20. [Content Brief]
[3]. Albers, L.J., A. Musenga, and M.A. Raggi, Iloperidone: a new benzisoxazole atypical antipsychotic drug. Is it novel enough to impact the crowded atypical antipsychotic market? Expert Opin Investig Drugs, 2008. 17(1): p. 61-75. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Iloperidone hydrochloride Related Classifications
HY-17410A Related Classifications
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