1. GPCR/G Protein
    Neuronal Signaling
  2. mAChR
  3. VU0453595

VU0453595 

Cat. No.: HY-120023
Handling Instructions

VU0453595 is a highly selective, systemically active M1 positive allosteric modulator (PAM, EC50=2140 nM) for the research of schizophrenia.

For research use only. We do not sell to patients.

VU0453595 Chemical Structure

VU0453595 Chemical Structure

CAS No. : 1432436-13-9

Size Price Stock Quantity
5 mg USD 120 In-stock
Estimated Time of Arrival: December 31
10 mg USD 200 In-stock
Estimated Time of Arrival: December 31
25 mg USD 390 In-stock
Estimated Time of Arrival: December 31
50 mg USD 600 In-stock
Estimated Time of Arrival: December 31
100 mg USD 900 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

VU0453595 is a highly selective, systemically active M1 positive allosteric modulator (PAM, EC50=2140 nM) for the research of schizophrenia[1][2].

In Vitro

Application of M1 PAM VU0453595 (3 μM) induces a transient increase in excitability of medium spiny neurons (MSNs)[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

VU0453595 potentiates M1-mediated muscarinic long-term depression (mLTD)[1].
VU0453595 (1-10 mg/kg; i.p.) reverses behavioral deficits induced by repeated phencyclidine (PCP) administration[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57BL6/J mice (8-9 weeks old)[1]
Dosage: 1, 3, or 10 mg/kg
Administration: Intraperitoneal (i.p.); 10 mL/kg; administered 30 min before the social interaction test
Result: Rescued deficits in social interaction observed in PCP-treated mice.
Molecular Weight

322.34

Formula

C₁₈H₁₅FN₄O

CAS No.
SMILES

O=C1N(CC2=CC=C(C3=CN(C)N=C3)C=C2F)CC4=NC=CC=C41

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (310.23 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1023 mL 15.5116 mL 31.0231 mL
5 mM 0.6205 mL 3.1023 mL 6.2046 mL
10 mM 0.3102 mL 1.5512 mL 3.1023 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (7.76 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (7.76 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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  • Molarity Calculator

  • Dilution Calculator

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

VU0453595VU 0453595VU-0453595mAChRMuscarinic acetylcholine receptorsystemicallyM1positiveallostericmodulatorPAMschizophreniaInhibitorinhibitorinhibit

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Product Name:
VU0453595
Cat. No.:
HY-120023
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