VU6004256
Based on 1 Customer Validation
VU6004256 is a potent and selective M1 muscarinic positive allosteric modulator (PAM) with an EC50 value of 155 nM. VU6004256 has the potential for the research of schizophrenia.
For research use only. We do not sell to patients.
- Purity: 99.61%
- CAS No.: 2011034-33-4
- Formula: C25H25F2N5O2
- Molecular Weight:465.50
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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mAChR1 155 nM (EC50) |
VU6004256 (3, 10 mg/kg; i.p.) reverses the performance impairments in novel object recognition and cue-mediated fear conditioning tasks and reduces hyper locomotor activity in NR1 KD mice[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Adult male NR1 KD mice[1]
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Dosage:10 mg/kg
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Administration:I.p.
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Result:Showed no effect on pyramidal cell firing rate in WT littermate controls, significantly reduced pyramidal cell firing rate in NR1 KD mice.
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Animal Model:Wild-type and NR1 KD mice[1]
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Dosage:3, 10 mg/kg
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Administration:I.p.
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Result:Dose-dependently reduced locomotor activity in NR1 KD, but not in WT mice, resulted in dose-dependent increases in recognition index in WT and NR1 KD mice; improved performance on test day in cue-mediated conditioned freezing in NR1 KD but not WT mice.
Chemical Information
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CAS No. 2011034-33-4
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Appearance Solid
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Molecular Weight 465.50
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Formula C25H25F2N5O2
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Color White to off-white
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SMILES
O=C(C1=CN(CC2=CC=C(C3=CN(C)N=C3)N=C2)C4=C1C(F)=CC(F)=C4)N[C@@H]5[C@@H](O)CCCC5
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Purity & Documentation
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Data Sheet (275 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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