Asenapine-13C,d3 maleate
Asenapine-13C,d3 Maleate is the deuterium labeled and 13C-Asenapine Maleate (HY-11100). Asenapine (Org 5222) Maleate, an atypical antipsychotic, is an antagonist of serotonin receptors (pKi: 8.4-10.5), adrenoceptors (pKi: 8.9-9.5), dopamine receptors (pKi: 8.9-9.4) and histamine receptors (pKi: 8.2-9.0). Asenapine Maleate can be used in the research of schizophrenia and bipolar disorder.
For research use only. We do not sell to patients.
- Formula: C2013CH17D3ClNO5
- Molecular Weight:405.85
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All 5-HT Receptor Isoforms
MoreAll Adrenergic Receptor Isoforms
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Biological Activity
Description
In Vitro
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Application
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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Unlabeled CAS 153172-37-3
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Molecular Weight 405.85
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Formula C2013CH17D3ClNO5
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SMILES
[H][C@@]12C3=C(OC4=C([C@]1(CN(C2)[13C]([2H])([2H])[2H])[H])C=CC=C4)C=CC(Cl)=C3.OC(/C=C/C(O)=O)=O
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Synonyms
Org 5222-13C,d3 maleate
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Shahid M, et al. Asenapine: a novel psychopharmacologic agent with a unique human receptor signature. J Psychopharmacol. 2009 Jan;23(1):65-73. [Content Brief]
[2]. Olivia Frånberg, et al. Asenapine, a novel psychopharmacologic agent: preclinical evidence for clinical effects in schizophrenia. Psychopharmacology (Berl). 2008 Feb;196(3):417-29. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Asenapine-13C,d3 maleate Related Classifications
HY-W769200 Related Classifications
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Keywords
- Asenapine-13C,d3
- Org 5222-13C,d3
- Isotope-Labeled Compounds
- 5-HT Receptor
- Adrenergic Receptor
- Dopamine Receptor
- Histamine Receptor
- psychopharmacologic
- psychopharmacological
- dopamine
- serotonin
- noradrenaline
- norepinephrine
- histamine
- receptor
- subtypes
- schizophrenia
- bipolar disorder
- antidepressant
- Inhibitor
- inhibitor
- inhibit