1. GPCR/G Protein
    Neuronal Signaling
  2. Dopamine Receptor
    mAChR
  3. Clozapine D8

Clozapine D8 (Synonyms: HF 1854 D8)

Cat. No.: HY-14539S
Handling Instructions

Clozapine D8 (HF 1854 D8) is the deuterium labeled Clozapine. Clozapine, an antipsychotic, is a potent antagonist of dopamine and a number of other receptors, with a Ki of 9.5 nM for muscarinic M1 receptor. Clozapine is also a potent and selective agonist at the muscarinic M4 receptor (EC50=11 nM).

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Clozapine D8 Chemical Structure

Clozapine D8 Chemical Structure

CAS No. : 1185053-50-2

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Description

Clozapine D8 (HF 1854 D8) is the deuterium labeled Clozapine. Clozapine, an antipsychotic, is a potent antagonist of dopamine and a number of other receptors, with a Ki of 9.5 nM for muscarinic M1 receptor. Clozapine is also a potent and selective agonist at the muscarinic M4 receptor (EC50=11 nM)[1][2][3][4].

Molecular Weight

334.87

Formula

C₁₈H₁₁D₈ClN₄

CAS No.

1185053-50-2

SMILES

CN1C([2H])([2H])C([2H])([2H])N(C2=NC3=CC(Cl)=CC=C3NC4=CC=CC=C24)C([2H])([2H])C1([2H])[2H]

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Clozapine D8HF 1854 D8Clozapine D 8Clozapine D-8Dopamine ReceptormAChRMuscarinic acetylcholine receptorantipsychoticmuscarinicbehavioralInhibitorinhibitorinhibit

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