Clozapine-d8
Based on 1 Customer Validation
Clozapine-d8 is the deuterium labeled Clozapine. Clozapine is an antipsychotic used for the research of schizophrenia. Clozapine has high affinity for a number of neuroreceptors.
For research use only. We do not sell to patients.
- Purity: 99.48%
- CAS No.: 1185053-50-2
- Formula: C18H11D8ClN4
- Molecular Weight:334.87
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 1185053-50-2
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Unlabeled Cas 5786-21-0
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Appearance Solid
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Molecular Weight 334.87
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Formula C18H11D8ClN4
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Color Light yellow to yellow
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SMILES
CN1C([2H])([2H])C([2H])([2H])N(C2=NC3=CC(Cl)=CC=C3NC4=CC=CC=C24)C([2H])([2H])C1([2H])[2H]
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Synonyms
HF 1854-d8
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 50 mg/mL (149.31 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (278 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Seeman P, et al. Clozapine, a fast-off-D2 antipsychotic. ACS Chem Neurosci. 2014 Jan 15;5(1):24-9. [Content Brief]
[4]. Moreno JL, et al. Persistent effects of chronic clozapine on the cellular and behavioral responses to LSD in mice. Psychopharmacology (Berl). 2013 Jan;225(1):217-26. [Content Brief]
[5]. Zorn SH, et al. Clozapine is a potent and selective muscarinic M4 receptor agonist. Eur J Pharmacol. 1994 Nov 15;269(3):R1-2. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.9862 mL | 14.9312 mL | 29.8623 mL | 74.6558 mL |
| 5 mM | 0.5972 mL | 2.9862 mL | 5.9725 mL | 14.9312 mL | |
| 10 mM | 0.2986 mL | 1.4931 mL | 2.9862 mL | 7.4656 mL | |
| 15 mM | 0.1991 mL | 0.9954 mL | 1.9908 mL | 4.9771 mL | |
| 20 mM | 0.1493 mL | 0.7466 mL | 1.4931 mL | 3.7328 mL | |
| 25 mM | 0.1194 mL | 0.5972 mL | 1.1945 mL | 2.9862 mL | |
| 30 mM | 0.0995 mL | 0.4977 mL | 0.9954 mL | 2.4885 mL | |
| 40 mM | 0.0747 mL | 0.3733 mL | 0.7466 mL | 1.8664 mL | |
| 50 mM | 0.0597 mL | 0.2986 mL | 0.5972 mL | 1.4931 mL | |
| 60 mM | 0.0498 mL | 0.2489 mL | 0.4977 mL | 1.2443 mL | |
| 80 mM | 0.0373 mL | 0.1866 mL | 0.3733 mL | 0.9332 mL | |
| 100 mM | 0.0299 mL | 0.1493 mL | 0.2986 mL | 0.7466 mL |
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