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Cat. No.: HY-183734

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Obuprazine

Obuprazine is an orally active dopamine D3 receptor agonist and 5-HT2A receptor antagonist with IC₅₀ values of 0.37 and 4.19 nM, respectively. Obuprazine acts as a G protein-coupled receptor modulater. Obuprazine can be used for the research of schizophrenia.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 2640663-79-0
화학식: C₂₀H₂₄Cl₂N₄O₂
분자량:423.34

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Obuprazine Chemical Structure

CAS No.: 2640663-79-0

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- Parmacokinetics
- In Vivo
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[1]

D₃ Receptor

0.37 nM (IC₅₀)

5-HT_2A Receptor

4.19 nM (IC₅₀)

All Dopamine Receptor Isoforms :

All 5-HT Receptor Isoforms :

In Vitro

Obuprazine acts as a potent agonist in cells stably expressing the dopamine D3 receptor, reducing cAMP levels with an EC₅₀ of 0.6 nM^[1].
Obuprazine potently inhibits 5-HT2A receptor-mediated calcium flux in stably expressing cells with an IC₅₀ of 2.21 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	T_max	C_max	AUC_0-t	AUC_0-∞	T_1/2	MRT
Mice^[1]	5 mg/kg	p.o.	0.5 h	673.0 ng/mL	1844.0 ng·h/mL	1970.0 ng·h/mL	1.9 h	3.1 h

In Vivo

Obuprazine (1 mg/kg; p.o.; single dose) exhibits antipsychotic effect on rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Male F344 rats (6-8 weeks) with schizophrenia^[1]
Dosage:

1 mg/kg
Administration:

p.o.; single dose
Result:

Exhibited an avoidance response inhibition rate (CAR value) of 18.5%.
Showed antipsychotic effect on rats.

Chemical Information

CAS No. 2640663-79-0
분자량 423.34
화학식 C₂₀H₂₄Cl₂N₄O₂
SMILES

ClC1=C(C=CC=C1Cl)N2CCN(CC2)CC[C@H]3C[C@@H](C3)NC(C4=NC=CO4)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Chen JY, et al. Salt containing piperazine polycyclic derivative, crystal form thereof, preparation method therefor, and use thereof. WO2022228447A1.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
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CAS No.:
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Obuprazine

All Dopamine Receptor Isoforms

All 5-HT Receptor Isoforms