(S)-(-)-5-Fluorowillardiine (hydrochloride) (Synonyms: (5S)-Fluorowillardiine hydrochloride; (S)-5-Fluorowillardiine hydrochloride)

Name: (S)-(-)-5-Fluorowillardiine (hydrochloride)
Brand: MedChemExpress
SKU: HY-16713A
Rating: 4.5 (0 reviews)

Cat. No.: HY-16713A Purity: 99.03%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

(S)-(-)-5-Fluorowillardiine ((5S)-Fluorowillardiine; (S)-5-Fluorowillardiine) hydrochloride is a potent, highly selective non-NMDA ionotropic glutamate receptor (iGluR, AMPA/Kainate receptor) agonist. (S)-(-)-5-Fluorowillardiine hydrochloride activates high-affinity AMPA-preferring receptors (EC₅₀ = 0.70 μM) and low-affinity kainate-preferring receptors (EC₅₀ = 170 μM), thereby inducing biphasic dose-dependent neurotoxicity/excitotoxicity. (S)-(-)-5-Fluorowillardiine hydrochloride is applicable to research related to schizophrenia, temporal lobe epilepsy, and bipolar disorder.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

(S)-(-)-5-Fluorowillardiine (hydrochloride) 화학구조

CAS No. : 1321546-70-6

사이즈	재고	수량
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water ready for reconstitution	해외재고보유	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in Water	해외재고보유	Estimated Time of Arrival: December 31
Solid
5 mg	해외재고보유	Estimated Time of Arrival: December 31
10 mg	해외재고보유	Estimated Time of Arrival: December 31
25 mg	해외재고보유	Estimated Time of Arrival: December 31
50 mg	해외재고보유	Estimated Time of Arrival: December 31
100 mg	견적 받기
200 mg	견적 받기

or 대량구매 문의

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 1 Customer Validation

Other Forms of (S)-(-)-5-Fluorowillardiine (hydrochloride):

(S)-(-)-5-Fluorowillardiine 견적 받기

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All iGluR Isoform Specific Products:

View All Isoforms

AMPA Receptor NMDA Receptor Kainate Receptor

Biological Activity
순도&문서
References
고객리뷰

제품 설명

IC₅₀ & Target

AMPA Receptor

In Vitro

(S)-(-)-5-Fluorowillardiine (10-100 μM; 24 h) hydrochloride induces > 90% neurotoxicity in primary cultured murine cortical neurones via a biphasic mechanism, with high-affinity component activity at AMPA receptors (EC₅₀ = 0.70 μM) and low-affinity component activity at kainate receptors (EC₅₀ = 170 μM)^[1].
(S)-(-)-5-Fluorowillardiine (200 nM-60 μM) hydrochloride potently activates AMPA/kainate receptors on primary dissociated cultures of mouse embryonic hippocampal neurons with an equilibrium EC₅₀ of 1.47 μM, induces strong desensitization (92.5%), exhibits cross-desensitization with other willardiine derivatives, and produces a prolonged inward tail current following agonist removal^[2].
(S)-(-)-5-Fluorowillardiine (0.1 nM-1 mM; 2 h) hydrochloride binds to mouse GluK5 kainate receptor subunits expressed in Sf9 cell membranes with a K_i of 1.79 μM, and exhibits similar affinity for GluK5 and GluK1 subunits^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

분자량

253.62

화학식

C₇H₉ClFN₃O₄

CAS No.

1321546-70-6

Appearance

Solid

Color

White to off-white

SMILES

OC([C@@H](N)CN1C=C(F)C(NC1=O)=O)=O.[H]Cl

선적

Room temperature in continental US; may vary elsewhere.

보관

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

용액&용해도

In Vitro:

H₂O : 6.67 mg/mL (26.30 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.9429 mL	19.7145 mL	39.4291 mL
5 mM	0.7886 mL	3.9429 mL	7.8858 mL
10 mM	0.3943 mL	1.9715 mL	3.9429 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

순도&문서

Purity: 99.03%

Select Batch:

Data Sheet (292 KB) SDS (252 KB)

COA (251 KB) RP-HPLC (247 KB) LCMS (94 KB)

Handling Instructions (2659 KB)

References

[1]. Larm JA, et al. (S)-5-fluorowillardiine-mediated neurotoxicity in cultured murine cortical neurones occurs via AMPA and kainate receptors. Eur J Pharmacol. 1996;314(1-2):249-254. [Content Brief]

[2]. Patneau DK, et al. Activation and desensitization of AMPA/kainate receptors by novel derivatives of willardiine. J Neurosci. 1992;12(2):595-606. [Content Brief]

[3]. Møllerud S, et al. A pharmacological profile of the high-affinity GluK5 kainate receptor. Eur J Pharmacol. 2016;788:315-320. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	3.9429 mL	19.7145 mL	39.4291 mL	98.5727 mL
	5 mM	0.7886 mL	3.9429 mL	7.8858 mL	19.7145 mL
	10 mM	0.3943 mL	1.9715 mL	3.9429 mL	9.8573 mL
	15 mM	0.2629 mL	1.3143 mL	2.6286 mL	6.5715 mL
	20 mM	0.1971 mL	0.9857 mL	1.9715 mL	4.9286 mL
	25 mM	0.1577 mL	0.7886 mL	1.5772 mL	3.9429 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

(S)-(-)-5-Fluorowillardiine (hydrochloride) Related Classifications

Neurological Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(S)-(-)-5-Fluorowillardiine (hydrochloride)1321546-70-6(5S)-Fluorowillardiine(S)-5-FluorowillardiineiGluRIonotropic glutamate receptorsInhibitorinhibitorinhibit

최근 본 상품:

상품명

Requested Quantity *

고객명 *

호칭

메일주소 *

전화번호 *

Department

회사명 *

City

도

Country or Region *

비고

상품명

Lot #

고객명 *

메일주소 *

전화번호

Department *

회사명 *

Country or Region *

비고

Name
이메일 *

	Sorry, but the email address you supplied was invalid.

(S)-(-)-5-Fluorowillardiine (hydrochloride) (Synonyms: (5S)-Fluorowillardiine hydrochloride; (S)-5-Fluorowillardiine hydrochloride)

고객리뷰

Other Forms of (S)-(-)-5-Fluorowillardiine (hydrochloride):

(S)-(-)-5-Fluorowillardiine (hydrochloride) Related Antibodies

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All iGluR Isoform Specific Products:

Biological Activity

순도&문서

References

고객리뷰

(S)-(-)-5-Fluorowillardiine (hydrochloride) Related Antibodies

몰농도 계산기

농도 희석 계산기

Complete Stock Solution Preparation Table

(S)-(-)-5-Fluorowillardiine (hydrochloride) Related Classifications

Keywords:

최근 본 상품:

고객리뷰

Request for HNMR Report

SAFETY DATA SHEET (SDS)

Request for HNMR Report