1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. iGluR

Naspm (Synonyms: 1-Naphthylacetyl spermine)

Cat. No.: HY-12506 Purity: >96.0%
Handling Instructions

Naspm (1-Naphthyl acetyl spermine), a synthetic analogue of Joro spider toxin, is a calcium permeable AMPA (CP-AMPA) receptors antagonist.

For research use only. We do not sell to patients.

Naspm Chemical Structure

Naspm Chemical Structure

CAS No. : 122306-11-0

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 106 In-stock
Estimated Time of Arrival: December 31
5 mg USD 96 In-stock
Estimated Time of Arrival: December 31
10 mg USD 130 In-stock
Estimated Time of Arrival: December 31
50 mg USD 460 In-stock
Estimated Time of Arrival: December 31
100 mg USD 810 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Other Forms of Naspm:

Top Publications Citing Use of Products

    Naspm purchased from MCE. Usage Cited in: Toxicol In Vitro. 2017 Oct;44:57-65.

    A Transwell invasion assay of cells is used to measure invasiveness after treatment with L-glutamate, propofol, 1-Naphthyl acetyl spermine (NAS), or (R, S)-AMPA.
    • Biological Activity

    • Technical Information

    • Purity & Documentation

    • References

    Description

    Naspm (1-Naphthyl acetyl spermine), a synthetic analogue of Joro spider toxin, is a calcium permeable AMPA (CP-AMPA) receptors antagonist.

    In Vitro

    NASPM selectively suppresses the inwardly rectifying and Ca2+-permeable AMPA receptors expressed in type II neurons. It has no effect on AMPA receptors in type I neurons. At -60 mV, NASPM suppresses AMPA receptors in type II neurons with an IC50 value of 0.33 µM. The blocking effect of NASPM on the Ca2+-permeable AMPA receptors is use and voltage-dependent[1].

    Solvent & Solubility
    In Vitro: 

    DMSO : 10 mg/mL (26.99 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.6988 mL 13.4942 mL 26.9884 mL
    5 mM 0.5398 mL 2.6988 mL 5.3977 mL
    10 mM 0.2699 mL 1.3494 mL 2.6988 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 1 mg/mL (2.70 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 1 mg/mL (2.70 mM); Clear solution

    • 3.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 1 mg/mL (2.70 mM); Clear solution

    References
    Molecular Weight

    370.53

    Formula

    C₂₂H₃₄N₄O

    CAS No.

    122306-11-0

    SMILES

    O=C(NCCCNCCCCNCCCN)CC1=C2C=CC=CC2=CC=C1

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Shipping

    Room temperature in continental US; may vary elsewhere

    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass   Concentration   Volume   Molecular Weight *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
    × = ×
    C1   V1   C2   V2

    Inquiry Online

    Your information is safe with us. * Required Fields.

    Product name

     

    Salutation

    Applicant name *

     

    Email address *

    Phone number *

     

    Organization name *

    Country or Region *

     

    Requested quantity *

    Remarks

    Bulk Inquiry

    Inquiry Information

    Product Name:
    Naspm
    Cat. No.:
    HY-12506
    Quantity:

    Naspm

    Cat. No.: HY-12506