1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. iGluR

Naspm (Synonyms: 1-Naphthylacetyl spermine)

Cat. No.: HY-12506 Purity: >96.0%
Handling Instructions

Naspm (1-Naphthyl acetyl spermine), a synthetic analogue of Joro spider toxin, is a calcium permeable AMPA (CP-AMPA) receptors antagonist.

For research use only. We do not sell to patients.

Naspm Chemical Structure

Naspm Chemical Structure

CAS No. : 122306-11-0

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 106 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
5 mg USD 96 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
10 mg USD 130 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
50 mg USD 460 In-stock
Stock in the United States
Estimated Time of Arrival: December 31
100 mg USD 810 In-stock
Stock in the United States
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Other Forms of Naspm:

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

Naspm (1-Naphthyl acetyl spermine), a synthetic analogue of Joro spider toxin, is a calcium permeable AMPA (CP-AMPA) receptors antagonist.

In Vitro

NASPM selectively suppresses the inwardly rectifying and Ca2+-permeable AMPA receptors expressed in type II neurons. It has no effect on AMPA receptors in type I neurons. At -60 mV, NASPM suppresses AMPA receptors in type II neurons with an IC50 value of 0.33 µM. The blocking effect of NASPM on the Ca2+-permeable AMPA receptors is use and voltage-dependent[1].

References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 2.6988 mL 13.4942 mL 26.9884 mL
5 mM 0.5398 mL 2.6988 mL 5.3977 mL
10 mM 0.2699 mL 1.3494 mL 2.6988 mL
Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

370.53

Formula

C₂₂H₃₄N₄O

CAS No.

122306-11-0

SMILES

O=C(NCCCNCCCCNCCCN)CC1=C2C=CC=CC2=CC=C1

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

10 mM in DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
Naspm
Cat. No.:
HY-12506
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