Synthesis of diaminobutane derivatives as potent Ca(2+)-permeable AMPA receptor antagonists

  • Bioorg Med Chem Lett. 2001 Oct 8;11(19):2663-6. doi: 10.1016/s0960-894x(01)00530-3.
Y Yoneda  1 ,  S Kawajiri ,  M Sugimura ,  K Osanai ,  F Kito ,  E Ota ,  T Mimura
Affiliations
  • 1. Medicinal Chemistry Research Laboratory, Daiichi Pharmaceutical Co., Ltd., 16-13, Kitakasai 1-Chome, Edogawa-ku, Tokyo 134-8630, Japan. [email protected]
PMID: 11551773 DOI: 10.1016/s0960-894x(01)00530-3
Abstract

We synthesized diaminobutane derivatives as potent CA(2+)-permeable AMPA Receptor antagonists with non-hypotensive activity. Compound 10c showed selective CA(2+)-permeable AMPA Receptor Antagonist activity and neuroprotective effects in transient global ischemia models in gerbils.