Naspm trihydrochloride
Based on 8 publication(s) in Google Scholar
Naspm trihydrochloride (1-Naphthylacetyl spermine trihydrochloride), a synthetic analogue of Joro spider toxin, is a calcium permeable AMPA (CP-AMPA) receptors antagonist.
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- Pureté: 98.50%
- CAS No.: 1049731-36-3
- Formule: C22H37Cl3N4O
- Masse moléculaire:479.91
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Stockage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Naspm trihydrochloride
More- J Headache Pain. 2022 Aug 10;23(1):98. [Abstract]
- Cell Rep. 2023 Dec 3;42(12):113551. [Abstract]
- Cell Rep. 2020 Nov 10;33(6):108369. [Abstract]
- Neurobiol Dis. 2024 May:194:106471. [Abstract]
- iScience. 2023 Mar 3;26(4):106322. [Abstract]
- Neuroscience. 2021 Nov 1:475:220-228. [Abstract]
- Brain Res. 2026 Jul 15:1883:150291. [Abstract]
- Toxicol In Vitro. 2017 Oct:44:57-65. [Abstract]
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Activité biologique
Description
IC50 & Target
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AMPA Receptor |
In Vitro
NASPM selectively suppresses the inwardly rectifying and Ca2+-permeable AMPA receptors expressed in type II neurons. It has no effect on AMPA receptors in type I neurons. At -60 mV, NASPM suppresses AMPA receptors in type II neurons with an IC50 value of 0.33 μM. The blocking effect of NASPM on the Ca2+-permeable AMPA receptors is use and voltage-dependent[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1049731-36-3
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Appearance Solid
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Masse moléculaire 479.91
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Formule C22H37Cl3N4O
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Color White to off-white
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SMILES
[H]Cl.[H]Cl.[H]Cl.O=C(NCCCNCCCCNCCCN)CC1=C2C=CC=CC2=CC=C1
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Synonyms
1-Naphthylacetyl spermine trihydrochloride
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (8)
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Journal Impact Factor
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Most Recent
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J Headache Pain
Dopamine receptor D2 regulates GLUA1-containing AMPA receptor trafficking and central sensitization through the PI3K signaling pathway in a male rat model of chronic migraine. [Abstract]2022 Aug 10;23(1):98. PMID: 35948867 -
Cell Rep
Single-cell RNA sequencing uncovers the cell type-dependent transcriptomic changes in the retrosplenial cortex after peripheral nerve injury. [Abstract]2023 Dec 3;42(12):113551. PMID: 38048224 -
Cell Rep
Restoration of Cingulate Long-Term Depression by Enhancing Non-apoptotic Caspase 3 Alleviates Peripheral Pain Hypersensitivity. [Abstract]2020 Nov 10;33(6):108369. PMID: 33176141 -
Neurobiol Dis
Spinal nerve transection-induced upregulation of SAP97 via promoting membrane trafficking of GluA1-containing AMPA receptors in the dorsal horn contributes to the pathogenesis of neuropathic pain. [Abstract]2024 May:194:106471. PMID: 38461868 -
iScience
Synaptic scaling of corticostriatal circuits underlies hyperactivity in GABA Transporter-1 deficient mice. [Abstract]2023 Mar 3;26(4):106322. PMID: 36968092 -
Neuroscience
2021 Nov 1:475:220-228. PMID: 34509547 -
Brain Res
Upregulation of synapse-associated protein 97 in the spinal dorsal horn exacerbates inflammatory pain through mediating GluA1-containing AMPARs membrane trafficking. [Abstract]2026 Jul 15:1883:150291. PMID: 41916464 -
Toxicol In Vitro
Propofol inhibits invasion and proliferation of C6 glioma cells by regulating the Ca2+ permeable AMPA receptor-system xc- pathway. [Abstract]2017 Oct:44:57-65. PMID: 28663055
Naspm trihydrochloride purchased from MedChemExpress. Usage Cited in: Toxicol In Vitro. 2017 Oct:44:57-65. [Abstract]
A Transwell invasion assay of cells is used to measure invasiveness after treatment with L-glutamate, propofol, 1-Naphthyl acetyl spermine (NAS), or (R, S)-AMPA.
Solvant et solubilité
In Vitro:
H2O : 50 mg/mL (104.19 mM; Need ultrasonic)
DMSO : 6.4 mg/mL (13.34 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (208.37 mM); Clear solution; Need ultrasonic
Pureté et documentation
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Fiche technique (269 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO / H2O | 1 mM | 2.0837 mL | 10.4186 mL | 20.8372 mL | 52.0931 mL |
| 5 mM | 0.4167 mL | 2.0837 mL | 4.1674 mL | 10.4186 mL | |
| 10 mM | 0.2084 mL | 1.0419 mL | 2.0837 mL | 5.2093 mL | |
| H2O | 15 mM | 0.1389 mL | 0.6946 mL | 1.3891 mL | 3.4729 mL |
| 20 mM | 0.1042 mL | 0.5209 mL | 1.0419 mL | 2.6047 mL | |
| 25 mM | 0.0833 mL | 0.4167 mL | 0.8335 mL | 2.0837 mL | |
| 30 mM | 0.0695 mL | 0.3473 mL | 0.6946 mL | 1.7364 mL | |
| 40 mM | 0.0521 mL | 0.2605 mL | 0.5209 mL | 1.3023 mL | |
| 50 mM | 0.0417 mL | 0.2084 mL | 0.4167 mL | 1.0419 mL | |
| 60 mM | 0.0347 mL | 0.1736 mL | 0.3473 mL | 0.8682 mL | |
| 80 mM | 0.0260 mL | 0.1302 mL | 0.2605 mL | 0.6512 mL | |
| 100 mM | 0.0208 mL | 0.1042 mL | 0.2084 mL | 0.5209 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Naspm trihydrochloride Related Classifications
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