Synthesis of polyamine derivatives having non-hypotensive Ca2 +-permeable AMPA receptor antagonist activity

  • Bioorg Med Chem Lett. 2001 May 21;11(10):1261-4. doi: 10.1016/s0960-894x(01)00170-6.
Y Yoneda  1 ,  S Kawajiri ,  A Hasegawa ,  F Kito ,  S Katano ,  E Takano ,  T Mimura
Affiliations
  • 1. Medicinal Chemistry Research Laboratory, Daiichi Pharmaceutical Co, Ltd, Tokyo, Japan. [email protected]
PMID: 11392532 DOI: 10.1016/s0960-894x(01)00170-6
Abstract

In order to obtain non-hypotensive and Ca2+-permeable AMPA Receptor antagonists, we have synthesized a series of 1,4-bis(4-piperidinylmethyl)diaminobutanes. Compounds 13b, c, f had desirable properties.