SB 258741 hydrochloride
SB 258741 hydrochloride is a specific 5-HT7 receptor antagonist and can be used for the research of schizophrenia.
For research use only. We do not sell to patients.
- Formula: C19H31ClN2O2S
- Molecular Weight:386.98
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All 5-HT Receptor Isoforms
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Biological Activity
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5-HT7 Receptor |
SB-258741 behaves as a partial inverse agonist, the antagonist potency (apparent pKB) is 8.47[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Wistar rats, 250 –300 g in the phencyclidine (PCP)-disrupted prepulse inhibition (PPI) and PCP-disrupted social interaction (SIT) paradigm, 200 – 250 g in the catalepsy, motility, and D-amphetamine hyperactivity paradigms[1]
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Dosage:0.56, 2.3, 4.6 and 9.1 mg/kg
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Administration:Subcutaneous injection, once or daily for 3 days (social interaction test)
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Result:Reversed hyperactivity induced by D-amphet-amine over 0.56 mg/kg, and reduced motility at 4.6 and 9.1 mg/kg.
Did not reverse D-Amphetamine-disrupted PPI, but enhanced PCP-disrupted PPI.
Reduced PCP (2 mg/kg)-induced hyperactivity.
Chemical Information
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Molecular Weight 386.98
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Formula C19H31ClN2O2S
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SMILES
O=S(N1[C@@H](CCN2CCC(C)CC2)CCC1)(C3=CC=CC(C)=C3)=O.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Pouzet B, et al. Effects of the 5-HT(7) receptor antagonist SB-258741 in animal models for schizophrenia. Pharmacol Biochem Behav. 2002 Apr;71(4):655-65. [Content Brief]
[2]. Mahé C, et al. Differential inverse agonist efficacies of SB-258719, SB-258741 and SB-269970 at human recombinant serotonin 5-HT7 receptors. Eur J Pharmacol. 2004 Jul 14;495(2-3):97-102. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SB 258741 hydrochloride Related Classifications
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