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Cat. No.: HY-180422

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(-)-UH 232

(-)-UH 232 is a central dopamine (DA) receptor agonist. (-)-UH 232 weakly decreases 3, 4-dihydroxyphenylalanine (DOPA) formation in striatal and limbic brain regions in rats. (-)-UH 232 can be used for the research of neurological diseases including parkinson's disease and schizophrenia.

For research use only. We do not sell to patients.

CAS No.: 95999-11-4
Formula: C₁₈H₂₉NO
Molecular Weight:275.44

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

(-)-UH 232 Chemical Structure

CAS No.: 95999-11-4

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
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Biological Activity

Description

All Dopamine Receptor Isoforms :

In Vivo

(-)-UH 232 (0.8-204 μmol/kg; s.c.; single dose) acts as a weak central dopamine receptor agonist in rats, as evidenced by its modest reduction of striatal and limbic DOPA formation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Sprague-Dawley rats (male, 200-300 g)^[1]
Dosage:

0.8, 3.2, 13, 52, 204 μmol/kg
Administration:

s.c.; single dose
Result:

Failed to significantly influence locomotor activity in non-pretreated rats at doses up to 52 μmol/kg.
Did not antagonize Reserpine (HY-N0480)-induced hypomotility at 204 μmol/kg.
Produced a weak trend towards reduced cortical DOPA formation, with a significant 15% decrease only at 52 μmol/kg in non-pretreated rats.
Dose-dependently decreased DOPA formation in limbic and striatal regions of reserpinized rats.

Chemical Information

CAS No. 95999-11-4
Molecular Weight 275.44
Formula C₁₈H₂₉NO
SMILES

O(C)C1=C2C([C@@H](C)[C@@H](N(CCC)CCC)CC2)=CC=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Svensson K, et al. (+)-UH 232 and (+)-UH 242: novel stereoselective dopamine receptor antagonists with preferential action on autoreceptors. J Neural Transm. 1986;65(1):1-27. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- In Vivo
Chemical Information
Purity & Documentation
References

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(-)-UH 232

All Dopamine Receptor Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

(-)-UH 232 Related Classifications

HY-180422 Related Classifications