2. GPCR/G Protein Neuronal Signaling
  3. Dopamine Receptor
  4. (-)-UH 232

(-)-UH 232 is a central dopamine (DA) receptor agonist. (-)-UH 232 weakly decreases 3, 4-dihydroxyphenylalanine (DOPA) formation in striatal and limbic brain regions in rats. (-)-UH 232 can be used for the research of neurological diseases including parkinson's disease and schizophrenia.

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(-)-UH 232

(-)-UH 232 Chemical Structure

CAS No. : 95999-11-4

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(-)-UH 232 Related Antibodies

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Description

(-)-UH 232 is a central dopamine (DA) receptor agonist. (-)-UH 232 weakly decreases 3, 4-dihydroxyphenylalanine (DOPA) formation in striatal and limbic brain regions in rats. (-)-UH 232 can be used for the research of neurological diseases including parkinson's disease and schizophrenia[1].

In Vivo

(-)-UH 232 (0.8-204 μmol/kg; s.c.; single dose) acts as a weak central dopamine receptor agonist in rats, as evidenced by its modest reduction of striatal and limbic DOPA formation[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague-Dawley rats (male, 200-300 g)[1]
Dosage: 0.8, 3.2, 13, 52, 204 μmol/kg
Administration: s.c.; single dose
Result: Failed to significantly influence locomotor activity in non-pretreated rats at doses up to 52 μmol/kg.
Did not antagonize Reserpine (HY-N0480)-induced hypomotility at 204 μmol/kg.
Produced a weak trend towards reduced cortical DOPA formation, with a significant 15% decrease only at 52 μmol/kg in non-pretreated rats.
Dose-dependently decreased DOPA formation in limbic and striatal regions of reserpinized rats.
Molecular Weight

275.44

Formula

C18H29NO
CAS No.
SMILES

O(C)C1=C2C([C@@H](C)[C@@H](N(CCC)CCC)CC2)=CC=C1
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Purity & Documentation
References
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(-)-UH 232 Related Classifications

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Keywords:

(-)-UH 23295999-11-4Dopamine Receptornon-pretreated ratsparkinson's diseasereserpine-induced akinesiaschizophrenianeurological diseasesdopamine receptor modulation modelsstriatumbrain regionsSprague-Dawley ratsreserpinized ratsDOPA formationdopamine (DA) receptor agonistlimbic regionInhibitorinhibitorinhibit

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