1. GPCR/G Protein
    Neuronal Signaling
  2. mGluR
  3. mGluR5 modulator 1

mGluR5 modulator 1 

Cat. No.: HY-141832
Handling Instructions

mGluR5 modulator 1 is a mGluR5 positive allosteric modulator. mGluR5 modulator 1 can be used for the research of the schizophrenia and cognitive impairments.

For research use only. We do not sell to patients.

mGluR5 modulator 1 Chemical Structure

mGluR5 modulator 1 Chemical Structure

CAS No. : 1261171-52-1

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Description

mGluR5 modulator 1 is a mGluR5 positive allosteric modulator. mGluR5 modulator 1 can be used for the research of the schizophrenia and cognitive impairments[1].

IC50 & Target

mGluR5[1]

In Vitro

mGluR5 modulator 1 (compound 2c; 0.1-0.00001 nM) potentiates the L-glutamate and DHPG responses to the same maximum response as the orthosteric agonists alone in the Ca2+ mobilization and IP1 accumulation assays[1].
mGluR5 modulator 1 (0.1-0.00001 nM) potentiates the L-glutamate and DHPG responses above the orthosteric agonist maximal response in the ERK1/2 phosphorylation assay[1].
mGluR5 modulator 1 induces mGlu5 internalization in the absence of add orthosteric agonist or antagonist[1].
mGluR5 modulator 1 potentiates the responses induced by both orthosteric agonists (L-glutamate or DHPG) in Ca2+ mobilization (pKB=5.4 and 5.3, respecyively), inositol monophosphate accumulation, and ERK1/2 phosphorylation signaling (pKB=5.88 and 5.4, respecyively) assays in HEK293A-mGlu5-low cells[1].
mGluR5 modulator 1 enhances the effect of DHPG in cortical neurons with pEC50 values of 6.32 and 6.33 in Ca2+ mobilization and inositol monophosphate (IP1) accumulation assays[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

363.81

Formula

C₁₈H₁₉ClFN₃O₂

CAS No.
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mGluR5 modulator 1
Cat. No.:
HY-141832
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