ALX-5407
ALX-5407 ((R)-NFPS) is a selective and orally active glycine transporter GlyT1 inhibitor with an IC50 value of 3 nM. ALX-5407 can be used the research of N-methyl-D-aspartate-receptor function and schizophrenia.
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- CAS No.: 571147-18-7
- 화학식: C24H24FNO3
- 분자량:393.45
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| COS-7 | IC50 |
3 nM
Compound: ALX-5407
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Inhibition of [3H]glycine uptake at rat glycine transporter 1 expressed in african green monkey COS7 cells
Inhibition of [3H]glycine uptake at rat glycine transporter 1 expressed in african green monkey COS7 cells
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[PMID: 19013063] |
| JAR | IC50 |
0.39 nM
Compound: ALX5407
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Inhibition of GlyT1 in human JAR cells assessed as inhibition of [3H]glycine uptake preincubated for 1 mins measured after 2 hrs by liquid scintillation counting
Inhibition of GlyT1 in human JAR cells assessed as inhibition of [3H]glycine uptake preincubated for 1 mins measured after 2 hrs by liquid scintillation counting
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[PMID: 21975065] |
| T98G | IC50 |
4.8 nM
Compound: ALX-5407
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Inhibition of [3H]glycine uptake in human T98G cells
Inhibition of [3H]glycine uptake in human T98G cells
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[PMID: 19013063] |
ALX-5407 (0-1 mM) GlyT1- or GlyT2-dependently inhibits glycine transport and blocks [3H]glycine uptake in rat brain and QT6-1C cells with an IC50 value of 3 nM[1]. ALX-5407 (50 nM) shows slow dissociation kinetics in QT6-1C cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 571147-18-7
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분자량 393.45
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화학식 C24H24FNO3
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SMILES
OC(CN(C)CC[C@H](C1=CC=C(C=C1)F)OC2=CC=C(C3=CC=CC=C3)C=C2)=O
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Synonyms
(R)-NFPS
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ALX-5407 Related Classifications
HY-10711 Related Classifications
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