WYE-103914
WYE-103914 is an orally active α7 nAChR (EC50 = 0.49 µM for rat α7 nAChR, EC50 = 0.57 µM for human α7 nAChR) agonist. WYE-103914 exhibits the ability to enhance memory in multiple cognitive models. WYE-103914 is used in combination with antipsychotic drugs. WYE-103914 can be used for research on schizophrenia.
For research use only. We do not sell to patients.
- CAS No.: 1204607-09-9
- Formula: C21H27FN4O
- Molecular Weight:370.46
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| CHO | IC50 |
1.3 μM
Compound: 16
|
Binding affinity to human ERG expressed in CHO cells
Binding affinity to human ERG expressed in CHO cells
|
[PMID: 20465311] |
| GH4-C1 | EC50 |
0.07 μM
Compound: 16
|
Agonist activity at rat alpha7 nAChR expressed in rat GH4C1 cells assessed as calcium flux by FLIPR
Agonist activity at rat alpha7 nAChR expressed in rat GH4C1 cells assessed as calcium flux by FLIPR
|
[PMID: 20465311] |
| GH4-C1 | EC50 |
490 nM
Compound: 16
|
Agonist activity at rat alpha7 nAChR expressed in rat GH4C1 cells by whole cell patch-clamp electrophysiology
Agonist activity at rat alpha7 nAChR expressed in rat GH4C1 cells by whole cell patch-clamp electrophysiology
|
[PMID: 20465311] |
| HEK293 | IC50 |
>30 μM
Compound: 16
|
Agonist activity at human 5HT3A receptor expressed in HEK293 cells by FLIPR assay
Agonist activity at human 5HT3A receptor expressed in HEK293 cells by FLIPR assay
|
[PMID: 20465311] |
Chemical Information
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CAS No. 1204607-09-9
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Molecular Weight 370.46
-
Formula C21H27FN4O
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SMILES
O=C(NC1=CC=C(C2=CC=C(F)C=C2)N=C1)NCCCCN3CCCCC3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)