2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. nAChR
  4. WYE-103914

WYE-103914 is an orally active α7 nAChR (EC50 = 0.49 µM for rat α7 nAChR, EC50 = 0.57 µM for human α7 nAChR) agonist. WYE-103914 exhibits the ability to enhance memory in multiple cognitive models. WYE-103914 is used in combination with antipsychotic drugs. WYE-103914 can be used for research on schizophrenia.

For research use only. We do not sell to patients.

WYE-103914

WYE-103914 Chemical Structure

CAS No. : 1204607-09-9

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WYE-103914 Related Antibodies

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Description

WYE-103914 is an orally active α7 nAChR (EC50 = 0.49 µM for rat α7 nAChR, EC50 = 0.57 µM for human α7 nAChR) agonist. WYE-103914 exhibits the ability to enhance memory in multiple cognitive models. WYE-103914 is used in combination with antipsychotic drugs. WYE-103914 can be used for research on schizophrenia[1].

Cellular Effect
Cell Line Type Value Description References
CHO IC50
1.3 μM
Compound: 16
Binding affinity to human ERG expressed in CHO cells
Binding affinity to human ERG expressed in CHO cells
[PMID: 20465311]
GH4-C1 EC50
0.07 μM
Compound: 16
Agonist activity at rat alpha7 nAChR expressed in rat GH4C1 cells assessed as calcium flux by FLIPR
Agonist activity at rat alpha7 nAChR expressed in rat GH4C1 cells assessed as calcium flux by FLIPR
[PMID: 20465311]
GH4-C1 EC50
490 nM
Compound: 16
Agonist activity at rat alpha7 nAChR expressed in rat GH4C1 cells by whole cell patch-clamp electrophysiology
Agonist activity at rat alpha7 nAChR expressed in rat GH4C1 cells by whole cell patch-clamp electrophysiology
[PMID: 20465311]
HEK293 IC50
>30 μM
Compound: 16
Agonist activity at human 5HT3A receptor expressed in HEK293 cells by FLIPR assay
Agonist activity at human 5HT3A receptor expressed in HEK293 cells by FLIPR assay
[PMID: 20465311]
Molecular Weight

370.46

Formula

C21H27FN4O
CAS No.
SMILES

O=C(NC1=CC=C(C2=CC=C(F)C=C2)N=C1)NCCCCN3CCCCC3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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WYE-103914 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

WYE-1039141204607-09-9WYE103914WYE 103914nAChRNicotinic acetylcholine receptorsα7 nAChRantipsychoticschizophreniaInhibitorinhibitorinhibit

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