1. GPCR/G Protein
    Neuronal Signaling
  2. Neurokinin Receptor
  3. Osanetant

Osanetant (Synonyms: SR142801)

Cat. No.: HY-14551 Purity: >98.0%
Handling Instructions

Osanetant (SR142801) is a selective NK3 receptor antagonist. Osanetant produces anxiolytic- and antidepressant-like effects and is researched for schizophrenia.

For research use only. We do not sell to patients.

Osanetant Chemical Structure

Osanetant Chemical Structure

CAS No. : 160492-56-8

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 1041 In-stock
Estimated Time of Arrival: December 31
1 mg USD 260 In-stock
Estimated Time of Arrival: December 31
5 mg USD 780 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Osanetant (SR142801) is a selective NK3 receptor antagonist. Osanetant produces anxiolytic- and antidepressant-like effects and is researched for schizophrenia[1].

IC50 & Target[1]

NK3

 

In Vivo

Osanetant (SR142801; po; 1-10 mg/kg; 60 min before testing) significantly increases social interaction time[1].
Osanetant (ip; 5 and 10 mg/kg; 30 min before testing) decreases immobility time[1].

Animal Model: Male Mongolian gerbils of 7 weeks old (50-60 g)[1]
Dosage: 1, 3 and 10 mg/kg
Administration: Po; 60 min before testing
Result: Significantly increased social interaction time.
Molecular Weight

606.62

Formula

C₃₅H₄₁Cl₂N₃O₂

CAS No.

160492-56-8

SMILES

O=C(N1C[[email protected]@](CCCN2CCC(N(C(C)=O)C)(C3=CC=CC=C3)CC2)(C4=CC=C(Cl)C(Cl)=C4)CCC1)C5=CC=CC=C5

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
References

Purity: >98.0%

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Keywords:

OsanetantSR142801SR 142801SR-142801Neurokinin ReceptorNK receptorNK3receptoranxiolytic-antidepressant-likeeffectsschizophreniaInhibitorinhibitorinhibit

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