MDL 100748
MDL 100748 is an NMDA receptor glycine site antagonist. MDL 100748 modulates NMDA receptor function by acting at the strychnine-insensitive glycine site, which is required for NMDA receptor activation alongside glutamate. MDL 100748 decreases response rates in operant conditioning sessions in phencyclidin (PCP)-trained rats. MDL 100748 can be used for reserach on dementias and schizophrenia.
For research use only. We do not sell to patients.
- CAS No.: 130613-18-2
- Formula: C12H8Cl2N2O4
- Molecular Weight:315.11
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
IC50 & Target
[1]|
NMDA Receptor |
In Vitro
MDL 100748 inhibits [3H]glycine binding to NMDA receptor glycine sites in rat brain membranes with an IC50 of 70 nM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Sprague-Dawley (adult male; trained to discriminate 2 mg/kg PCP from saline via two-lever operant conditioning under FR32)[1]
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Dosage:1 mg/kg; 1.7 mg/kg; 3 mg/kg
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Administration:i.p.; single dose; 30 minutes prior to test sessions
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Result:Produced 0% PCP-lever selection across all tested doses.
Had an ED50 of 3 mg/kg for suppression of response rates.
Chemical Information
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CAS No. 130613-18-2
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Molecular Weight 315.11
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Formula C12H8Cl2N2O4
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SMILES
O=C(C1=CC(NCC(O)=O)=C2C(Cl)=CC(Cl)=CC2=N1)O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Nicholson KL, et al. The discriminative stimulus effects of N-methyl-D-aspartate glycine-site ligands in NMDA antagonist-trained rats. Psychopharmacology (Berl). 2009;203(2):441-451. [Content Brief]
[2]. Baron BM, et al. Pharmacological characterization of MDL 105,519, an NMDA receptor glycine site antagonist. Eur J Pharmacol. 1997;323(2-3):181-192. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MDL 100748 Related Classifications
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