130613-18-2
130613-18-2
Chemical Structure
MDL 100748
- CAS No.: 130613-18-2
- Formula:C12H8Cl2N2O4
- Molecular Weight:315.11
InChIKey: UJAOIPMPKPYADL-UHFFFAOYSA-N
SMILES: O=C(C1=CC(NCC(O)=O)=C2C(Cl)=CC(Cl)=CC2=N1)O
Biological Activity: MDL 100748 is an NMDA receptor glycine site antagonist. MDL 100748 modulates NMDA receptor function by acting at the strychnine-insensitive glycine site, which is required for NMDA receptor activation alongside glutamate. MDL 100748 decreases response rates in operant conditioning sessions in phencyclidin (PCP)-trained rats. MDL 100748 can be used for reserach on dementias and schizophrenia[1].
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MDL 100748 | MDL 100748 is an NMDA receptor glycine site antagonist. MDL 100748 modulates NMDA receptor function by acting at the strychnine-insensitive glycine site, which is required for NMDA receptor activation alongside glutamate. MDL 100748 decreases response rates in operant conditioning sessions in phencyclidin (PCP)-trained rats. MDL 100748 can be used for reserach on dementias and schizophrenia. | |||||||||||||||||||||
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