SSR180711
Based on 1 Customer Validation
SSR180711 is a potent and subtype-selective α7 agonist with activity in Alzheimer's disease and schizophrenia research. SSR180711 can be used to study subtypes of intracerebral hemorrhage associated with cerebral small vessel disease. SSR180711 shows potential in electrophysiological and behavioral studies to evaluate its effects on cognitive function. SSR180711 also has potential for studying cerebrovascular lesions and their effects.
For research use only. We do not sell to patients.
- Purity : 99.52%
- CAS No.: 298198-52-4
- Formula: C14H17BrN2O2
- Molecular Weight:325.20
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
All Endogenous Metabolite Isoforms
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Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| GH4-C1 | EC50 |
0.9 μM
Compound: 29, SSR180711
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Partial agonist activity at human alpha7 nAChR expressed in GH4C1 cells relative to acetylcholine
Partial agonist activity at human alpha7 nAChR expressed in GH4C1 cells relative to acetylcholine
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[PMID: 21919481] |
| HEK293 | IC50 |
>3160 nM
Compound: 5
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Displacement of [3H]LY278584 from human 5HT3 receptor expressed in HEK293 cells
Displacement of [3H]LY278584 from human 5HT3 receptor expressed in HEK293 cells
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[PMID: 19576766] |
| IMR-32 | IC50 |
>6480 nM
Compound: 5
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Displacement of [3H]epibatidine from alpha3 nAChR in human IMR32 cells
Displacement of [3H]epibatidine from alpha3 nAChR in human IMR32 cells
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[PMID: 19576766] |
| Oocyte | EC50 |
4.4 μM
Compound: 29, SSR180711
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Partial agonist activity at human alpha7 nAChR expressed in Xenopus oocytes relative to acetylcholine
Partial agonist activity at human alpha7 nAChR expressed in Xenopus oocytes relative to acetylcholine
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[PMID: 21919481] |
Chemical Information
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CAS No. 298198-52-4
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Appearance Solid
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Molecular Weight 325.20
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Formula C14H17BrN2O2
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Color Off-white to light brown
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SMILES
O=C(N1CCN2CCC1CC2)OC3=CC=C(C=C3)Br
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Protocols
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Protocol for Water Maze
The Morris Water Maze is a rodent spatial learning and memory assay in which a mouse or rat swims in opaque water to find an escape platform; in the hidden-platform version, the animal cannot see the platform and must use distal extra-maze cues to learn its fixed spatial location. The assay primarily measures hippocampus-dependent spatial learning during acquisition trials and spatial reference memory during probe trials after platform removal; readouts include escape latency, swim path length, swim speed, quadrant occupancy, platform-site crossings, and proximity to the former platform location.
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Alzheimer’s Disease Modeling
Alzheimer’s Disease (AD) is a neurodegenerative disorder characterized by a progressive decline in cognitive functions and loss of specific types of neurons and synapses. Alzheimer's symptoms can be simulated in mice by injecting drugs (such as Aβ) or genetically modified.
Purity & Documentation
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Data Sheet (271 KB)
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SDS (644 KB)
- English - EN (644 KB)
- Français - FR (644 KB)
- Deutsch - DE (644 KB)
- Norwegian - NO (644 KB)
- Español - ES (644 KB)
- Swedish - SV (644 KB)
- Italian - IT (644 KB)
- Korean - KR (644 KB)
- Portuguese - PT (644 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SSR180711 Related Classifications
HY-167824 Related Classifications
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