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Cat. No.: HY-117021

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RO 5073012

RO 5073012 is a selective, orally active and brain-penetrant TAAR1 agonist. RO 5073012 shows a K_i of 6 nM for hTAAR1 and EC₅₀ values of 23 and 25 nM for mTAAR1 and rTAAR1. RO 5073012 can be used for the research of neurological disease, such as schizophrenia.

For research use only. We do not sell to patients.

CAS No.: 1020814-70-3
Formula: C₁₃H₁₆ClN₃
Molecular Weight:249.74

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

RO 5073012 Chemical Structure

CAS No.: 1020814-70-3

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

hTAAR1

6 nM (Ki)

mTAAR1

23 nM (EC₅₀)

rTAAR1

25 nM (EC₅₀)

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	EC₅₀	23 nM Compound: 24, Ro-5073012	Agonist activity at human TAAR1 receptor expressed in HEK293 cells after 30 mins Agonist activity at human TAAR1 receptor expressed in HEK293 cells after 30 mins	[PMID: 22795332]
HEK293	EC₅₀	23 nM Compound: 24, Ro-5073012	Agonist activity at mouse TAAR1 receptor expressed in HEK293 cells after 30 mins Agonist activity at mouse TAAR1 receptor expressed in HEK293 cells after 30 mins	[PMID: 22795332]
HEK293	EC₅₀	25 nM Compound: 24, Ro-5073012	Agonist activity at rat TAAR1 receptor expressed in HEK293 cells after 30 mins Agonist activity at rat TAAR1 receptor expressed in HEK293 cells after 30 mins	[PMID: 22795332]

Chemical Information

CAS No. 1020814-70-3
Molecular Weight 249.74
Formula C₁₃H₁₆ClN₃
SMILES

CC(N(C1=CC=C(Cl)C=C1)CC2=CN=CN2)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Galley G, et al. Optimisation of imidazole compounds as selective TAAR1 agonists: discovery of RO5073012. Bioorg Med Chem Lett. 2012 Aug 15;22(16):5244-8. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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