Penfluridol (Standard)
Penfluridol (Standard) is the analytical standard of Penfluridol. This product is intended for research and analytical applications. Penfluridol (R-16341) is a potent, long-acting, first-generation, oral diphenylbutylpiperidine antipsychotic agent by targeting D2-like dopamine receptor. Penfluridol effectively inhibits TNFα-induced NF-κB activation and alleviates the severity of arthritis and colitis in vivo. Penfluridol is a Ca2+-calmodulin inhibitor. Penfluridol induces apoptosis and autophagy. Penfluridol is used for chronic schizophrenia, acute psychosis, Tourette syndrome and autoimmune diseases. Penfluridol inhibites the growth of E. faecalis planktonic cells with the MIC of 7.81 μg/ml.
For research use only. We do not sell to patients.
- CAS No.: 26864-56-2
- Formula: C28H27ClF5NO
- Molecular Weight:523.97
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Product Information
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Chemical Information
- Purity & Documentation
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Help & FAQs
Product Information
The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Chemical Information
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CAS No. 26864-56-2
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Molecular Weight 523.97
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Formula C28H27ClF5NO
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SMILES
OC1(C2=CC=C(Cl)C(C(F)(F)F)=C2)CCN(CCCC(C3=CC=C(F)C=C3)C4=CC=C(F)C=C4)CC1
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Synonyms
R-16341 (Standard)
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Eyal Zur, et al. Penfluridol, a Unique Psychiatric Medicine for the Treatment of Chronic Schizophrenia. Int J Pharm Compd. 2019 Mar-Apr;23(2):113-119. [Content Brief]
[2]. Szu-Yuan Wu, et al. Penfluridol triggers cytoprotective autophagy and cellular apoptosis through ROS induction and activation of the PP2A-modulated MAPK pathway in acute myeloid leukemia with different FLT3 statuses. J Biomed Sci. 2019 Aug 31;26(1):63. [Content Brief]
[3]. Yue-Hong Chen, et al. Penfluridol targets acid sphingomyelinase to inhibit TNF signaling and is therapeutic against inflammatory autoimmune diseases. Arthritis Res Ther. 2022 Jan 19;24(1):27. [Content Brief]
[4]. Xianghai Zeng, et al. Drug repurposing: Antimicrobial and antibiofilm effects of penfluridol against Enterococcus faecalis. Microbiologyopen. 2021 Jan;10(1):e1148. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Penfluridol (Standard) Related Classifications
Cat. No.: HY-B1077R
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- Penfluridol (Standard)
- 26864-56-2
- R-16341 (Standard)
- Reference Standards
- Calcium Channel
- Dopamine Receptor
- Autophagy
- Apoptosis
- Oral
- diphenylbutylpiperidine
- antipsychotic
- D2
- TNFα
- NF-κB
- arthritis
- colitis
- spleen naive CD4+T
- TH1
- TH17
- M1 macrophage
- chronic schizophrenia
- acute psychosis
- Tourette syndrome
- autoimmune
- E. faecalis
- planktonic
- Inhibitor
- inhibitor
- inhibit