PF-03463275 hydrochloride
PF-03463275 hydrochloride is a centrally penetrant, orally available, selective, and competitive GlyT1 (glycine transporter-1) reversible inhibitor, with a Ki of 11.6 nM. PF-03463275 hydrochloride has the potential for Schizophrenia research.
For research use only. We do not sell to patients.
- CAS No.: 1173177-11-1
- Formula: C19H24Cl3FN4O
- Molecular Weight:449.78
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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GLT1 116 nM (Ki) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | IC50 |
8500 nM
Compound: 10
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Inhibition human ERG expressed in HEK293 cells assessed as blockade of membrane current by patch clamp method
Inhibition human ERG expressed in HEK293 cells assessed as blockade of membrane current by patch clamp method
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[PMID: 19410451] |
Chemical Information
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CAS No. 1173177-11-1
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Molecular Weight 449.78
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Formula C19H24Cl3FN4O
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SMILES
O=C(C1=CN(C)C=N1)N(CC2=CC(Cl)=C(C=C2)F)C[C@@H]3[C@]4([H])[C@@]3([H])CN(C4)C.Cl.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Lowe JA 3rd, et al. The discovery of a structurally novel class of inhibitors of the type 1 glycine transporter [published correction appears in Bioorg Med Chem Lett. 2009 Aug 15;19(16):4885. Bronk, Brian S [added]; Schaeffer, Eric [added]]. Bioorg Med Chem Lett. 2009;19(11):2974-2976. [Content Brief]
[2]. Liu CN, Pettersen B, Seitis G, Osgood S, Somps C. GlyT1 inhibitor reduces oscillatory potentials of the electroretinogram in rats. Cutan Ocul Toxicol. 2014;33(3):206-211. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PF-03463275 hydrochloride Related Classifications
HY-10716 Related Classifications
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