1173177-11-1
1173177-11-1
Chemical Structure
PF-03463275 hydrochloride
- CAS 番号: 1173177-11-1
- Formula:C19H24Cl3FN4O
- Molecular Weight:449.78
IUPAC Name: N-(3-chloro-4-fluorobenzyl)-1-methyl-N-(((1R,5S,6r)-3-methyl-3-azabicyclo[3.1.0]hexan-6-yl)methyl)-1H-imidazole-4-carboxamide dihydrochloride
InChIKey: BHPFPDLKIFJVQN-JYECWNFBSA-N
SMILES: O=C(C1=CN(C)C=N1)N(CC2=CC(Cl)=C(C=C2)F)C[C@@H]3[C@]4([H])[C@@]3([H])CN(C4)C.Cl.Cl
Biological Activity: PF-03463275 hydrochloride is a centrally penetrant, orally available, selective, and competitive GlyT1 (glycine transporter-1) reversible inhibitor, with a Ki of 11.6 nM. PF-03463275 hydrochloride has the potential for Schizophrenia research[1][2].
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PF-03463275 hydrochloride | PF-03463275 hydrochloride is a centrally penetrant, orally available, selective, and competitive GlyT1 (glycine transporter-1) reversible inhibitor, with a Ki of 11.6 nM. PF-03463275 hydrochloride has the potential for Schizophrenia research. | |||||||||||||||||||||
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References
- [1]. Lowe JA 3rd, et al. The discovery of a structurally novel class of inhibitors of the type 1 glycine transporter [published correction appears in Bioorg Med Chem Lett. 2009 Aug 15;19(16):4885. Bronk, Brian S [added]; Schaeffer, Eric [added]]. Bioorg Med Chem Lett. 2009;19(11):2974-2976. [Content Brief]
- [2]. Liu CN, Pettersen B, Seitis G, Osgood S, Somps C. GlyT1 inhibitor reduces oscillatory potentials of the electroretinogram in rats. Cutan Ocul Toxicol. 2014;33(3):206-211. [Content Brief]
